tag:blogger.com,1999:blog-74937236062199367792024-03-15T09:41:28.102-05:00simply bloodDeconstructing blood cell research, building the hematology community ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.comBlogger220125tag:blogger.com,1999:blog-7493723606219936779.post-13027106700343933372024-02-09T08:37:00.000-06:002024-02-09T08:37:34.174-06:00Lab Spotlight: Tamplin Lab<span style="font-family: arial;"><br /></span><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj-cdJrq7PgRDmbSHEsmfL-fD_D2TKAfdf4GT9VQ3nO1WASk1YyKTWX-GVKqOWhbGJOJiWONeez-oC2yRjn3dyI9C6AuT1zlQl6tFBJpNYPXaefb9llxm2dA-7M33k_MM_rz2kkPNA6QHMncQpwFMd7yFfRiSp54GIIcEnFfo1XshSqdxa9ISoFMZvOZX1p/s4032/Halloween_2023%202.tiff" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="3024" data-original-width="4032" height="480" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj-cdJrq7PgRDmbSHEsmfL-fD_D2TKAfdf4GT9VQ3nO1WASk1YyKTWX-GVKqOWhbGJOJiWONeez-oC2yRjn3dyI9C6AuT1zlQl6tFBJpNYPXaefb9llxm2dA-7M33k_MM_rz2kkPNA6QHMncQpwFMd7yFfRiSp54GIIcEnFfo1XshSqdxa9ISoFMZvOZX1p/w640-h480/Halloween_2023%202.tiff" width="640" /></a></div><span style="background-color: white; font-family: arial;"><br /></span><div><span style="background-color: white; font-family: arial;">Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Tamplin Lab which is based out of the University of Wisconsin-Madison in the United States (</span><span style="background-color: white;"><span style="font-family: arial;"><a href="https://tamplin.crb.wisc.edu/staff/tamplin-owen/"><span style="color: #cc0000;">https://tamplin.crb.wisc.edu/staff/tamplin-owen/</span></a>).</span></span><div><span style="font-family: arial;"><span style="color: #757575;"><span style="font-size: 15px;"><br /></span></span><b> How long has your lab been open and who is in your lab currently?<br /></b><i>The lab first opened in January 2016 at the University of Illinois at Chicago, and we moved to the University of Wisconsin Madison during the pandemic in 2020. The lab currently has three graduate students, five undergraduates and one research technician.</i><br /><br /><b>What is the overarching research goal for your group?<br /></b><i>The main research theme is the hematopoietic stem cell microenvironment. We use zebrafish and mouse and models. We are interested in utilizing new technologies through collaboration to apply to our interest in the microenvironment.</i><br /><br /><b>What is your lab’s most significant accomplishment?<br /></b><i>I am most proud of building a strong track record in training. We have had trainees graduate recently with strong publications. Each trainee who has come through has developed their own interesting and novel story that they have seen through from beginning to end.</i><br /><br /><b>What is your philosophy in mentorship and lab leadership and how do you tailor that to levels of training?<br /></b><i>I want to encourage confidence and independence. I want trainees to become independent thinkers and scientists. I try to individualize this training to meet each person’s career goals. I like to pair undergraduates with graduate students for hands on training and mentorship in the lab. I like to have the undergraduates involved in projects – not just routine lab tasks. It is important for them to have a larger context for what they are doing. For the graduate students, I really try to develop their independence and confidence in how they can develop and pursue a project from start to finish.</i><br /><br /><b>What is the greatest challenge in being a principal investigator?</b><br /><i>So far, for me, it was navigating the lab through moving during the pandemic. Now we are back on track and everyone is working well together – we have successfully rebuilt a synergistic team.<br /></i><br /><b>Does your lab have any traditions or ways to maintain the lab culture?<br /></b><i>We have regular brunches, picnics, or dinners to celebrate birthdays or lab accomplishments. We are competitive in departmental spirit events around holidays – gingerbread house decorating and costume competitions. This helps to foster an inclusive and supportive environment where people are comfortable and trustful.<br /></i><br /><b>Where do you see the lab going over the next few years?<br /></b><i>I want to continue to recruit great graduate students to continue to mentor their career development. We would like to continue to build the collaborations that enable us to leverage new technologies.<br /></i><br /><b>Is there anything else you want the community to know about your lab?<br /></b><i>We are continuing efforts on promoting diversity in the department and at UW-Madison. I am involved in the diversity, equity, and inclusion Community of Practice at the UW School of Medicine and Public Health– this works across basic sciences and clinical departments to create a community for individuals from historically underrepresented groups.</i><br /><br /><b>How has interacting with ISEH supported your research?<br /></b><i>I really like ISEH’s community and networking opportunities. There is a lot of interest in the microenvironment and hematopoietic stem cell biology in the community that helps to foster new collaborations. There are also many opportunities to connect trainees to career development opportunities.</i><br /></span><div><i><span style="font-family: arial;"><br /></span></i></div><div><div style="background-color: white; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif;"><span style="font-family: arial;"><b>Owen Tamplin, PhD<br /></b>Department of Cell and Regenerative Biology</span></div><div style="background-color: white; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif;"><span style="font-family: arial;">University of Wisconsin-Madison, Madison, USA<br /><span style="background: transparent; text-decoration-line: none;"><a href="https://tamplin.crb.wisc.edu/staff/tamplin-owen/"><span style="color: #cc0000;">https://tamplin.crb.wisc.edu/staff/tamplin-owen/</span></a></span></span></div></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div><i style="color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;">Blog post contributed by Grant Rowe, MD, PhD (</span></i><span style="color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i><a href="https://twitter.com/bloodandtime1" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; color: #f53e3e; text-decoration-line: none;" target="_blank"><span style="color: #cc0000;">@bloodandtime1</span></a>), </i></span></span><i style="color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;">ISEH Publications Committee</span></i></div><div><i style="color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><br /></span></i></div><div><i style="color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><br /></span></i></div><div><i style="background-color: white; color: #757575; font-family: arial; font-size: 15px;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the</i><i style="background-color: white; color: #757575; font-family: arial; font-size: 15px;"> views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></div><div><i><br /></i></div><div><i><br /></i></div><div><i><br /></i></div></div></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-84697003576135553922024-01-23T16:22:00.006-06:002024-01-23T16:22:33.868-06:00Getting Involved in Science Policy (as a Scientist)<div class="separator"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi9FR1sfP3xOu2l6p6G39DW1D1RqSEFWQj3NX7ryEaCfnY17Jt5dne1QK-OA8oh3pDlvsnE8cOXRqw20uP8ai0HD8Jd_MroRguZVYndq-G6f5xhV7iCeTtMy9hTnMOh0DshvOONyzLVqG-ic7h4ehl6t6nkL0HweiTqMXbbi38mpXUjKdOjKr0LRY4JbhOR/s1600/NIC%20Policy%20Post.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em; text-align: center;"><img border="0" data-original-height="900" data-original-width="1600" height="360" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi9FR1sfP3xOu2l6p6G39DW1D1RqSEFWQj3NX7ryEaCfnY17Jt5dne1QK-OA8oh3pDlvsnE8cOXRqw20uP8ai0HD8Jd_MroRguZVYndq-G6f5xhV7iCeTtMy9hTnMOh0DshvOONyzLVqG-ic7h4ehl6t6nkL0HweiTqMXbbi38mpXUjKdOjKr0LRY4JbhOR/w640-h360/NIC%20Policy%20Post.png" width="640" /></a></div><span style="font-family: arial;"><b><i><br /></i></b></span><div><span style="font-family: arial;"><b><i>What is science policy?<br /></i></b>Science policy is a broad term encompassing a range of different career paths relevant to governmental allocation of resources towards scientific research. This can include job roles such as science communicator, science policy analyst, and scientific advisor for government agencies. Because of the large amount of funding needed for scientific research, legislation concerning scientific policy in most countries is often approved at a national or international level, and only a few countries have a provincial or state-level scientific policy apparatus. <br /><br /><i><b>How do different science policy roles fit together?</b><br /></i>Science policy often starts with an advocacy group (such as scientists in ISEH) having a special interest in passing a piece of legislation (such as governmental funding to study a disease, or modifying regulations surrounding a research topic). In the US, an advocacy group starts by meeting with the staff of an elected representative who sits on the relevant committee. During the meeting, the advocacy group is expected to submit material discussing the pros and cons of passing new legislation on the topic. If the lawmaker is convinced that this legislature is in the best interest of the public, their staff then drafts the scientific policy and accompanying background to be discussed by a committee of lawmakers. During the process of drafting legislation, it is possible that senior scientists (often academic and industry leaders) working in the field who are involved in part-time governmental advisory roles will provide input on the new legislature’s impacts. Subsequently, the legislation then undergoes a stringent process of back-and-forth evaluation, discussions, and voting before it can be passed. If the legislation is passed, individuals in industry and academic roles will then change their course of action according to the modified scientific policy. <br /><br />Frequently, individuals actively involved in scientific policy work have a scientific background. Notably, it is possible to do science policy part-time alongside a research role. For example, senior academic scientists are often involved in science policy as governmental science policy advisors alongside an academic position, or after retiring from an academic position. However, at lower level non-advisory roles, governmental science policy job positions tend to be full-time roles as policy analysts. Instead of advising on drafted scientific policy, these science policy job positions involve creating and drafting scientific policy legislation, analyzing impact of past legislation and the potential impact of the law under consideration, and summarizing their findings into reports for key stakeholders and elected officials to consider. <br /><br /><i><b>Getting started in scientific policy</b><br /></i>A simple first step to see if science policy is the right path for you is to gain an understanding of the types of jobs which exist and which might be a good fit for you. And the easiest way to do this is to speak with people actively involved in positions you might be interested in. Linkedin is a great resource with which to search for specific jobs or organizations of interest, and identify individuals with whom you might have a mutual connection with, such as a shared friend or alma mater. By speaking with individuals in a scientific policy position, you will better-understand what type of work science policy job roles entail and how to better-prepare for them. <br /><br />In parallel to gathering information from speaking with people, it may be a good idea to test the waters with online courses to see if it is the right job fit for you. Online courses offered for free or at relatively low prices, such as through EdX and Coursera, can be a simple way to learn more about science policy practices and gain the basic skills and terminology needed to succeed in a science policy job role. Similarly, many large universities freely publish course material online, which can be a great resource to better-understand science policy practices. <br /><br />Finally, as with most job positions, the best way to see if a science policy job is the right role for you is to try it out yourself. Science policy work can be started in parallel to work or studies, whether you’re a senior postdoc or an undergraduate student. A common transition step into science policy is to first try out becoming a science communicator or doing public engagement work. This will give you a better understanding of what the general public might be interested in, as well as improve your ability to simplify complex scientific details into condensed, more easily understood facts. Some ways to get started with science communication might be publishing social media or blog posts on interesting scientific news, or helping to raise awareness of lesser-known scientific issues through public engagement events such as school educational days.<br /><br />Another way to transition into science policy is through defined fellowships. As a result of the low number of scientists involved in science policy work, there has been an increasing number of fellowships designed for PhD-level scientists to become involved in public policy work. In the US, such programs include the AAAS Fellows program, which places PhD-awarded US citizens in various branches of government to perform science policy work. In addition, many scientific societies (such as American Society for Hematology (ASH)) are frequently looking for scientists to take more active roles in scientific policy development, such as to rally the public and lobby legislators for support. Working through scientific societies can be a great way to gain more engagement with the governmental science policy procedures. <br /><br /><i><b>Concluding Remarks</b><br /></i>As our understanding of science grows ever-more complex, more scientific policy officers are needed than ever before to act as a liaison between the scientific community and the general public, whether that means posting science through social media channels to reach different audiences or discussing the benefits of scientific research with members of our lawmaking bodies. Through work in science policy, we can help ensure that our scientific goals remain a priority for our legislators, communities, and society at large. </span><br /><div><br /></div><div><span style="font-family: arial;"><br /></span></div><div><p style="background-color: white;"><i><span style="color: #757575; font-family: arial;"><span style="font-size: 15px;">Blog post contributed by Ian Hsu (</span></span></i><span style="background-color: transparent; font-size: 15px;"><span style="color: #cc0000; font-family: arial;"><i><a href="https://twitter.com/ian_hsu7" target="_blank">@ian_hsu7</a></i></span></span><i><span style="color: #757575; font-family: arial;"><span style="font-size: 15px;">), Anne Stolz (</span></span></i><span style="background-color: transparent; font-size: 15px;"><span style="color: #cc0000; font-family: arial;"><i><a href="https://twitter.com/AnneStolz2" target="_blank">@AnneStolz2</a></i></span></span><i><span style="color: #757575; font-family: arial;"><span style="font-size: 15px;">), and the 2023-2024 ISEH New Investigators Committee</span></span></i></p><div class="separator" style="background-color: white; clear: both; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px; text-align: center;"><br /></div><i style="background-color: white; color: #757575; font-family: arial; font-size: 15px;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></div><div class="separator" style="clear: both; text-align: center;"><br /></div><br /></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-84816515958672322502023-11-30T13:20:00.003-06:002023-11-30T13:20:29.405-06:00What I Have Learned in My First 3.5 Years as Principal Investigator<span style="font-family: arial;"><b>What I Have Learned in My First 3.5 Years as Principal Investigator<br /></b><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiQ3_gErg2YmPyEpdFazUv9QE4Rzy0PzXPGawxNFK_a09wgI0ewV7pULZPCaxhs36HXIvC8w11Vk4dBMDBJHLwSeNBayVigw4UdN-ZbN1BnaDb-Lgupk1c5tFTI-DXKqB2-r_URcA-6G98TFhZAn8cxjwgIXHzLqhdZ3L6417k-pbgfT8RZkYJ_YhgFbIvq/s170/microscope.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="170" data-original-width="170" height="170" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiQ3_gErg2YmPyEpdFazUv9QE4Rzy0PzXPGawxNFK_a09wgI0ewV7pULZPCaxhs36HXIvC8w11Vk4dBMDBJHLwSeNBayVigw4UdN-ZbN1BnaDb-Lgupk1c5tFTI-DXKqB2-r_URcA-6G98TFhZAn8cxjwgIXHzLqhdZ3L6417k-pbgfT8RZkYJ_YhgFbIvq/s1600/microscope.png" width="170" /></a></div><br />I am a physician scientist at Boston Children’s Hospital. Our lab studies the changes that occur in blood formation across the lifespan and how this impacts age-biased blood diseases – this work is strongly driven by my perspective as a pediatric hematologist. In this post, I share some of the lessons that I have learned over the first 3+ years as a PI. This advice is not one-size-fits-all – you can take it or leave it, and I am sure everyone’s situation is different in one way or another. <br /><br /><i>You must spend money to make money. </i> When you start a lab, your institution may provide you with startup funds. What funding you receive is variable and open to negotiation. This funding is crucial to support your pet projects that are not externally funded, fill gaps in salary support, and in many cases, to support your own salary. Early on, I was overly protective of my startup., then I realized that the point of this money is to ‘start up’ your work to form a basis for externally funding your projects. Use it - but use it wisely.<br /><br /><i>Don’t let the perfect be the enemy of the good.</i> Your central focus as a new PI should be getting your first paper published. Grant reviewers will not hesitate to criticize young PIs as not having published enough. The current reality, however, is that publishing is increasingly (and in some ways justifiably) more difficult, so get that first paper out: find a solid observation, develop and consolidate it rigorously, efficiently, and get it published. You can’t have your first paper come out as your startup is dwindling. Assuming (at least one) revision is required, it can take >1.5 years from initial submission to the start of funding for NIH grants, so don’t hold out for a super high impact paper as your first one – once you have long-term funding, then you can go for the riskier work.<br /><br /><i>No one is perfect at hiring.</i> In most cases, we are choosing our co-workers based on a one-page resume and a one-hour interview, so it is no surprise that no one gets it perfect every time. Leverage their strengths, but don’t hold back constructive criticism regarding weaknesses.. And do not forget to remind to your mentees of all the progress that they make. Seek out institutional guidance and external opportunities on how to hire to help you grow comfortable making these decisions. <br /><br /><i>You’re going to spend a lot of time writing grants. </i> Starting out, frankly speaking, you are an easy target for reviewers – in most cases you don’t have a high-profile reputation and an extensive professional network as a buffer from criticism. Expect one in ten applications that you submit to be funded and plan accordingly and remember that your main job as PI is to provide the support your trainees require for growth. <br /><br /><i>Grow your network.</i> And I mean outside of your institution: the people in your field are your peer reviewers on papers and grants, and they may also invite you to speak at their seminars, which in turn increases both your network and profile. Use your new status to invite speakers and run seminars to grow your network. <br /><br /><i>Seek out collaborators early on. </i> Especially more senior PIs. Complementary expertise and partnership with a productive established investigator will give your grant applications a leg up and lend more weight to your papers. <br /><br />Feel free to contribute your own advice in the comments below!</span><br /><div><span style="font-family: arial;"><br /></span></div><div><span style="font-family: arial;"><br /></span></div><div><p style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><i><span style="font-family: arial;">Blog post contributed by Grant Rowe, MD, PhD (</span></i><span style="background-color: transparent;"><span style="font-family: arial;"><i><a href="https://twitter.com/bloodandtime1" style="background: transparent; color: #f53e3e; text-decoration-line: none;" target="_blank"><span style="color: #cc0000;">@bloodandtime1</span></a>), </i></span></span><i><span style="font-family: arial;">ISEH Publications Committee</span></i></p><p style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><i style="font-family: arial;"><br /></i></p><p style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><i style="font-family: arial;"></i></p><div class="separator" style="clear: both; text-align: center;"><i style="font-family: arial;"><a href="https://blogger.googleusercontent.com/img/a/AVvXsEjZTcbvkyloozDqrInHat1jVsuEn6wyVF9-Cf0k_bu4HEkUv-3uVKcbAGiIRYQmBZdYs2VuLP_wI0r3obFwLXrWy7FoDwftMjwC2xq1PezByF2IqExUxfst3EJSYGdvdBZYWvv2uKcmd0hCyYdstb5AXUy5TMxmCLEt8yemzqtMNgTLObx0Ryist_bYv2qy" style="margin-left: 1em; margin-right: 1em;"><img alt="" data-original-height="170" data-original-width="170" height="240" src="https://blogger.googleusercontent.com/img/a/AVvXsEjZTcbvkyloozDqrInHat1jVsuEn6wyVF9-Cf0k_bu4HEkUv-3uVKcbAGiIRYQmBZdYs2VuLP_wI0r3obFwLXrWy7FoDwftMjwC2xq1PezByF2IqExUxfst3EJSYGdvdBZYWvv2uKcmd0hCyYdstb5AXUy5TMxmCLEt8yemzqtMNgTLObx0Ryist_bYv2qy" width="240" /></a></i></div><i style="font-family: arial;"><br />Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i><p></p></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-81670800532544838522023-10-26T10:59:00.000-05:002023-10-26T10:59:00.320-05:00ISEH 2023 Annual Scientific Meeting – Highlights from the New Investigators Committee<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiuvQoNvRotGZOZXfA5hjgw-cMNoYqEMEUGbRZrplkiHEClKEZPPqBRfcq1e7b798rqEpI2VM4wEqznf1KVY_yY3CQLZ1GUGEnzO-Btb5fMkFrLoP4IOu_v4TTVBMNGg0EM9WpO2rOyskJ3a7Acc82cTAOtc8gqOtjR-XgW6R0d4_PReh_ZTRoVAvjdRVIc/s800/ISEH_931054-22_AM2023_WB_800x800_Instagram.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="800" data-original-width="800" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiuvQoNvRotGZOZXfA5hjgw-cMNoYqEMEUGbRZrplkiHEClKEZPPqBRfcq1e7b798rqEpI2VM4wEqznf1KVY_yY3CQLZ1GUGEnzO-Btb5fMkFrLoP4IOu_v4TTVBMNGg0EM9WpO2rOyskJ3a7Acc82cTAOtc8gqOtjR-XgW6R0d4_PReh_ZTRoVAvjdRVIc/w400-h400/ISEH_931054-22_AM2023_WB_800x800_Instagram.png" width="400" /></a></div><div class="separator"><span style="font-family: arial;">The 52nd ISEH Annual Scientific Meeting took place at the New York Marriott at the Brooklyn Bridge from 17-20 August 2023. Our Annual Scientific Meeting brought together more than 540 scientists and ISEH members from 25 different countries from around the world. This meeting in New York City was planned for 2020, but it had to be postponed due to the COVID-19 emergency. After three years, we finally got to roll our suitcases down the streets of NYC, which is a fantastic playground for networking. We were extremely happy and grateful to bring the community together again!</span></div><span style="font-family: arial;"><br /><b>The Science<br /></b>The meeting included many events that were targeted to a broad audience of scientists at various stages of their careers (from trainees to PIs). We had 31 invited speakers, 26 short talk presenters, 15 featured poster presentations and 217 poster presentations. The scientific sessions covered a wide range of topics from the molecular mechanisms of developmental and adult hematopoiesis, the role of the microenvironment and inflammation on hematopoietic stem cells, the biology behind myeloid and erythroid cell formation and function, and how all this information can be deregulated in hematopoietic malignancies. Here are some highlights from the ISEH New Investigators Committee.<br /><br />The Paul S. Frenette Lecture regrouped 4 speakers to discuss a hot topic in the field of hematopoiesis and hematopoietic malignancies: the microenvironment. Daniel Lucas, a former postdoc of Paul S. Frenette who is now Assistant Professor at Cincinnati Children’s Hospital, presented his work on the spatial organization of the bone marrow and highlighted his enormous toolbox to study hematopoiesis in the bone marrow niche. We also heard great presentations from 3 ISEH trainees (Gulce Perrin, Daozheng Yang and Shun Uemura) who presented us new biological insights into how specific cell types (adult and embryonic macrophages) and molecules (P-selectin and LATS1/2 inhibitor) can modulate hematopoietic stem cell function. We were also treated to fantastic talks from the 2023 ISEH awardees for the Donald Metcalfe Award (Peggy Goodell, Baylor College of Medicine, USA), the Janet Rowley Award (Nina Cabezas-Wallscheid, Max Planck Institute, Germany) and the McCulloch and Till Award (Daniel Starczynowski, Cincinnati Children’s Hospital, USA). Each presented a summary of their past and current research projects. These were extremely inspiring talks because they showed us a global picture of each scientist and their research, but also how they got to where they are now. In addition to the scientific sessions, we also had workshops and career development sessions dedicated to learning about different career paths and novel technologies, organized by ISEH members. <br /><br /><b>New Investigator Pre-meeting Workshop<br /></b>This workshop is simply a must for all trainees. It takes place the day before we kick-off the official meeting. It is an opportunity to present your scientific work to a panel of experts in the field, and to receive constructive feedback that will help you progress at early stages of your career. This year, it was organized by Adam C. Wilkinson (University of Oxford, UK), Louise Purton (University of Melbourne, Australia) and Marella de Bruijn (University of Oxford, UK). The ISEH New Investigators Committee also invited two speakers (Jennifer Trowbridge, The Jackson Laboratory, USA, and Peter Van Galen, Harvard Stem Cell Institute, USA) to give us their insights on efficient networking, and how important it is for your scientific career. Having a strong network will help you immensely when searching for a new career opportunity, so it was great to have their take on how networking became a vital part of their scientific journey. The “take-home” message was that you should attend all the social events at a scientific meeting because a lot of collaborations and opportunities arise from having a casual conversation outside the scientific sessions. <br /><br /><u>Best Oral Presentations<br /></u>1st Place, Marlies Vanden Bempt<br />2nd Place, Apoorva Thatavarty<br /><br /><u>Best Poster Presentations<br /></u>1st Place, Grace Meaker<br />2nd Place, Ilana Karp<br />3rd Place, Arushana Maknojia<br /><br /><b>New Investigator Award Session</b><br />This session is very popular because it regroups the best-scoring abstract submitted by PhD/MD and post-doctoral trainees. We were lucky to be joined by Katrin Ottersbach (University of Edinburgh, UK) as the NIC Invited Speaker. She presented us an overview of her work on developmental hematopoiesis and infant leukemogenesis. The goal of this session is to highlight talented trainees that are part of the ISEH community, and how their research is having a significant impact in the field of hematopoiesis. This year, we invited Fonteini Fotopoulou (DKFZ, HI-STEM, Germany), Daniel Tavakol (Columbia University, USA) and Alec Geßner (Goethe University Frankfurt, Germany) in the PhD/MD category. For the postdoctoral fellows, we invited Samuel Taylor (Albert Einstein College of Medicine, USA), Chloé Baron (Boston Children’s Hospital, USA) and Elanor Wainwright (Peter MacCallum Cancer Centre, Australia). All speakers gave outstanding presentations, and per usual, they had to answer many questions from the audience. Their presentations were judged and scored by 3 members of the NIC (Alba Rodriguez-Meira, Masayuki Yamashita and Linde A. Miles) and 3 PIs (Jennifer Trowbridge, Christopher Sturgeon and Charles de Boeck). The first prize winners were Fonteini Fotopoulou (student prize) and Samuel Taylor (postdoc prize).<br /><br /><b>New Investigator Technology Session<br /></b>The technology session highlights the expertise of students and postdocs that develop and utilize new experimental tools in their work. This year, the focus of the session was on the latest advances in clonal lineage tracing methods and multi-omics. Dr Li Li (Postdoc, Boston Children's Hospital, USA) introduced an improved Cas9 barcoding mouse line called DARLIN and described the Camellia-seq method for joint profiling of lineage, gene expression, chromatin accessibility and DNA methylation. Alec Geßner (PhD student, Goethe University Frankfurt, Germany) described a lentiviral barcoding technology called Clontracer to track patient-derived B-ALL cells in vitro. Finally, Alberto Bueno-Costa (PhD student, Josep Carreras Leukaemia Research Institute, Spain) introduced Smart-RRBS for simultaneous single-cell DNA methylation and transcriptomic analysis on patient-derived MDS cells. They took part in a lively discussion with the audience, answering questions and providing tips and tricks from their personal experience for designing and executing successful experiments using these methods.<br /><br /><b>Meet the Expert Mixer</b><br />One of our favorite networking event is the Meet the Expert Mixer. This session is all about networking in a relaxed atmosphere. We are always very fortunate to receive outstanding scientists to discuss with trainees about their science, and also to answer questions regarding the progression of their scientific career. It is also a great opportunity for trainees to connect with each other and to meet new people. This year, we were joined by Katrin Ottersbach (University of Edinburgh, UK), Nina Cabezas-Wallscheid (Max Planck Institute, Germany), Daniel Starczynowski (Cincinnati Children’s Hospital, USA), Ulrich Steidl (Albert Einstein College of Medicine, USA), Daphna Nachmani (The Alexander Silberman Institute of Life Science, Israel), Carolina Florian (Institut d'Investigació Biomèdica de Bellvitge, Spain), Adam C. Wilkinson (University of Oxford, UK), César Nombela-Arrieta (University Hospital Zürich, Switzerland), Stephanie Xie (University of Toronto, Canada) and Michael Kharas (Sloan Kettering Institute, USA). This event is coming back in 2024, so make sure to get your ticket when you register for the 2024 ISEH Annual Scientific Meeting.<br /><br /><b>New Investigator Career Session</b><br />The career session is a great opportunity for trainees to interact with panelists in various career paths and learn more about how they navigated transitioning from their training to academic and non-academic positions. The goal of this session is to provide trainees the ability to meet former trainees/faculty in the hematology field and learn about the diverse career trajectories possible both in and out of academic. This year the NIC invited three exceptional panelists - Dr. Brittany Woods (Manager, Competitive Intelligence at Prevail Therapeutics), Dr. Tanya Bondar (Deputy Editor at Blood Cancer Discovery), and Dr. Hamza Celik (Associate Director, Discovery Biology at Incyte) – all of whom have prior or current experience in the hematology field. The panelists each gave a quick introduction to their career paths followed by a Q&A session with attendees moderated by two NIC members (Alba Rodriguez-Meira and Linde A. Miles). The trainees in attendance asked outstanding questions with many questions focused on how to approach conversations with a PI about transitioning out of the lab and what additional resources may be available to learn about non-academic career paths. The panelists provided thoughtful insights and suggestions based on their experiences and extensive knowledge of their fields. Overall, it was a highly engaging session and great learning opportunity for trainees.<br /><br /><b>A Cruise on the Hudson River<br /></b>The closure of ISEH 2023 was nothing short of exciting as attendees embarked on a river cruise through the Hudson. The party started with astonishing views of the skyscrapers in New York City and a first round of drinks by the water. Shortly after, we approached the Statue of Liberty for a close view of this NYC landmark, as we were served dinner. The skilled barmen made sure to let us try their ample cocktail menu, and when the music started, trainees and PIs conquered the dance floor to show off their dancing skills. The impressive talent of some of the attendees grabbed the attention of the captain, who also joined us for a few dances as we were approaching the Manhattan docks. It was a memorable way to wrap up an exceptional conference and a truly remarkable event!<br /><br />We have now left The Big Apple, but we will see you at the 2024 ISEH Annual Scientific Meeting in The Windy City: Chicago, USA!<br /><br /><br /></span><p style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><i><span style="font-family: arial;">Blog post contributed by the </span></i><i><span style="font-family: arial;">ISEH New Investigators Committee</span></i></p><p style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><i style="font-family: arial;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></p><span style="font-family: arial;"><br /><br /><br /></span><div class="separator" style="clear: both; text-align: center;"><br /></div><br /><br />ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-56246663672489619432023-10-18T13:07:00.000-05:002023-10-18T13:07:24.704-05:00Living Medicine – lessons for the experimental hematologist<div class="separator"><br /></div><span style="font-family: arial;"><br />As a clinical hematologist, the publication of <i>Living Medicine</i> - a history of the development of bone marrow transplantation in humans - was required reading. However, I was pleasantly surprised to see that Dr. Appelbaum carefully reviews the history of the fundamental basic science of hematopoietic stem cells, the understanding of which forms a required basis for clinical transplantation. From the perspective of an experimental hematologist, it was fascinating to learn how the pioneers of clinical transplantation leveraged fundamental science done in mice into translational studies and iterative clinical trials to progressively develop, improve, and optimize allogeneic bone marrow transplantation. Laboratory based research was vital in the iterative trials that moved bone marrow transplantation from a high-risk intervention for patients with no other options to now a much safer front-line therapy for many blood diseases. Although Dr. Appelbaum justifiably emphasizes the foundational and bold work done in Seattle, he acknowledges the contribution of other researchers throughout the world. He also emphasizes the importance of advocacy of patients and families in supporting early research in bone marrow transplantation and places the patient experience at the center of his narrative. He also discusses the current state of basic research and its ongoing and potential impact on engineered cellular therapy and immunotherapy.<br /><div class="separator"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiJqN2XOsOFTTea6PaAn0lCz90EBstflgfltzESPDgGoFKOmQTA2tpClpucEU0V57jd41YvXokVRLaZbQ7AmyELe_iWX9jbDdfc0TuGHkad1ehA8Pj4G0VVsOwvymJuF67KMYn4LB3Lu4JNuSH9YrBDNB0BbCUPPC2X0y4QxeUuDfQuPQTEy5jck-5wE6cS/s608/Living%20Medicine%20Blog.png" imageanchor="1" style="clear: right; float: right; font-family: arial; margin-bottom: 1em; margin-left: 1em; text-align: center;"><img border="0" data-original-height="608" data-original-width="414" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiJqN2XOsOFTTea6PaAn0lCz90EBstflgfltzESPDgGoFKOmQTA2tpClpucEU0V57jd41YvXokVRLaZbQ7AmyELe_iWX9jbDdfc0TuGHkad1ehA8Pj4G0VVsOwvymJuF67KMYn4LB3Lu4JNuSH9YrBDNB0BbCUPPC2X0y4QxeUuDfQuPQTEy5jck-5wE6cS/s320/Living%20Medicine%20Blog.png" width="218" /></a></div></span><span style="font-family: arial;"><br />While this book on the surface appeals to clinicians engaged in bone marrow transplantation, it is also an inspiring read for basic scientists in hematology. It reminds us of the essential nature of our work in the formation of the rationale and premise for clinical innovations. By charting the arc from the basic studies demonstrating the existence and properties of the hematopoietic stem</span><span style="font-family: arial;"> cell to the current state of the art in bone marrow transplantation, Dr. Appelbaum’s work should inspire the current generation of basic scientists by illustrating the immense potential impact of our work. His description of the more recent foundational work in cancer immunotherapy and chimeric antigen receptor T-cells and the ongoing clinical translation of this work shows this history repeating itself for the hopeful ongoing benefit of patients.<br /><br /><i>Living Medicine</i> is available on amazon.com.<div class="separator" style="clear: both; text-align: center;"><br /></div></span><br /><div><span style="font-family: arial;"><br /></span></div><div><span style="font-family: arial;"><br /></span></div><div><p style="background-color: white;"><i style="color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;">Blog post contributed by Grant Rowe, MD, PhD (</span></i><span style="background-color: transparent; font-size: 15px;"><span style="font-family: arial;"><i><a href="https://twitter.com/bloodandtime1" target="_blank"><span style="color: #cc0000;">@bloodandtime1</span></a><span style="color: #757575;">), </span></i></span></span><i style="color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;">ISEH Publications Committee</span></i></p><p style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><i style="font-family: arial;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></p></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-35556224488214300572023-10-06T09:11:00.002-05:002023-10-13T13:11:18.675-05:00Lab Spotlight: Laurenti Lab<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjtXcuCI_TAz8rYECRIm6tg1dW_vcaviAM5HH3IzAR7F0Ob230lhycqbirQ75bOUSyY5blnmrkIWVX4pK7myjS8uoVpyZKNR8YyzXD7zL3Qbwawm35favXcuOev67o_59vn1aBfuJlF77YCYU_3BZPP3VZLltPCRX8iKCTJ45y1FVigrS-5wr0EG_zfk4P0/s1379/Laurenti%20Lab.jpg" style="margin-left: auto; margin-right: auto;"><span style="color: black;"><img border="0" data-original-height="1034" data-original-width="1379" height="480" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjtXcuCI_TAz8rYECRIm6tg1dW_vcaviAM5HH3IzAR7F0Ob230lhycqbirQ75bOUSyY5blnmrkIWVX4pK7myjS8uoVpyZKNR8YyzXD7zL3Qbwawm35favXcuOev67o_59vn1aBfuJlF77YCYU_3BZPP3VZLltPCRX8iKCTJ45y1FVigrS-5wr0EG_zfk4P0/w640-h480/Laurenti%20Lab.jpg" width="640" /></span></a></td></tr><tr><td class="tr-caption" style="text-align: center;"><span style="font-family: arial; font-size: x-small;">The Laurenti Lab, at Wellcome Cambridge Stem Cell Institute, Cambridge, UK</span></td></tr></tbody></table><span style="font-family: arial;"><br /> </span><div><span style="font-family: arial;">Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Laurenti Lab which is based out of the Cambridge Stem Cell Institute, at the University of Cambridge in the UK (<a href="https://www.stemcells.cam.ac.uk/people/pi/laurenti"><span style="color: #cc0000;">https://www.stemcells.cam.ac.uk/people/pi/laurenti</span></a>).<br /><br /><b>How long have you had your lab? And how many members make up your lab?<br /></b><i>I have started my group in September 2014, and currently our group is composed of seven people. Three postdocs, two PhD students and one research assistant, in addition to several students shared between our group and other research groups including; one bioinformatician and two postdocs.</i><br /><br /><b>What is the major research theme of your lab?</b><br /><i>Our lab is interested in deciphering human haematopoiesis across the lifetime, ideally at single cell resolution.</i><br /><br /><b>What is the most exciting project in your lab right now?<br /></b><i>We are very excited about the novel ways that we can use to quantify stem cell function during normal and stress-induced haematopoiesis, in ageing and inflammation. These include new single cell epigenetics technologies, different ways of performing clonal tracking in addition to many new options to maintain and/or expand the haematopoietic stem cells in vitro.</i><br /><br /><b>What is your approach to mentoring students in this lab?<br /></b><i>I enjoy mentoring students and approach each student differently. It all depends on the type of scientist they are and what are their needs. I believe establishing a relationship of transparency and trust is very important in mentoring students.</i><br /><br /><b>What is your lab’s most recent accomplishment?<br /></b><i>Thanks to everyone we have received some major grants including an ERC. In addition, our lab members were able to develop expertise in technologies new to our lab including spectral flow cytometry and single cell multiome analysis. But in the end, it is often the everyday seemingly smaller achievements that are the most important. </i><br /><br /><b>What facilities or equipment does your lab absolutely depend on?<br /></b><i>Flow cytometry, sequencing and primary samples.</i><br /><br /><b>Does your lab attend the ISEH Annual Meeting?<br /></b><i>Yes, there is always at least one person from the lab, who can tell everyone else about the exciting science.</i><br /><br /><b>What is the most beneficial aspect of ISEH membership for your lab?<br /></b><i>Apart from the annual meeting, the online webinars and activities are extremely useful. We had one of our students attending the career fair last year.</i><br /><br /><b>How do members of your lab celebrate accomplishments?<br /></b><i>Lots of cake and a “a little bit of bubbly”. I keep all the bottles with a reminder of the occasion and the signatures of those who contributed. It’s a great way to have memories of our accomplishments.<br /></i><br /><b>Does your lab have any fun traditions?<br /></b><i>Birthdays, cakes, going out for dinners and our lab retreat once a year.</i><br /><br /><b>What is the key to running a successful lab?<br /></b><i>I believe the key is listening to your people, provide them with guidance and mentorship. Collaboration is really important, it makes you more productive and it’s oftem more fun. Keep the excitement on and enjoy the science!</i><br /><br /><b>What has been your greatest challenge in managing your lab?<br /></b><i>Running the lab during COVID was though. My daughter was 1.5 years old at the time of the first lockdown. Parenting and running a lab with no support other than my wonderful husband who had to juggle the same issues was not easy. We also had no primary samples for more than one and a half year. For a lab working exclusively on human cells, that is definitely disruptive! But beyond pandemics, everyone in a team will have some life events sooner or later. Change and disruptions are part of life so I try to keep an open and flexible mind, go with the flow, and remember that with challenge most often come new and exciting opportunities.</i><br /><br /><b style="background-color: white;">Elisa Laurenti, PhD<br /></b><span style="background-color: white;">Human Haematopoietic Stem Cells Biology in Health and Disease</span></span></div><div><span style="font-family: arial;">Wellcome Cambridge Stem Cell Institute, Cambridge, UK<br style="background-color: white; color: #757575;" /><a href="https://www.stemcells.cam.ac.uk/people/pi/laurenti"><span style="color: #cc0000;">https://www.stemcells.cam.ac.uk/people/pi/laurenti</span></a><br /><br /><br /><i><span style="color: #757575;">Blog post contributed by Ahmed Waraky, Ph.D, a member of the ISEH Publications Committee.</span></i></span><span style="color: #757575;"><br /></span></div><div><span style="color: #757575; font-family: arial;"><br /></span></div><div><span style="color: #757575;"><i style="background-color: white; font-family: arial; font-size: 15px;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the</i><i style="background-color: white; font-family: arial; font-size: 15px;"> views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></span></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-48940988733512185682023-09-05T15:09:00.003-05:002023-09-05T15:11:57.368-05:00Lessons from Two Physician Scientists: Navigating the Transition to Independence<p><span style="font-family: arial;"><b>Lessons from Two Physician Scientists: Navigating the Transition to Independence</b></span></p><p><span style="font-family: arial;">Transitioning from a postdoctoral position to independence is a complex undertaking that requires careful planning and the support of mentors and mentees alike. While some researchers have experienced a smooth transition, for others, it has been more challenging. In order to gain insight into effectively managing the numerous issues that arise during this period, we turned to Drs. Ross Levine and Aaron Viny, who recently engaged in a webinar discussion with us on their relationship as mentor-mentee and their own experiences transitioning to independence.</span></p><p><span style="font-family: arial;">Dr. Ross Levine, having completed his MD at Johns Hopkins University, pursued hematology/oncology fellowship and residency at the Dana-Farber Cancer Institute before joining Memorial Sloan Kettering in New York City to establish his own lab. Dr. Viny, a physician scientist, earned his MD at Case Western Reserve University, followed by an internal medicine residency at Weill Cornell Medical College, and a hematology/oncology fellowship at Memorial Sloan Kettering where he worked in Dr. Levine's lab. He currently serves as an Assistant Professor at Columbia University, leading his own lab and studying the role of chromatin structure and cohesins in AML.</span></p><p><span style="font-family: arial;">Dr. Levine emphasized his philosophy on running a lab and mentoring young scientists. He stressed the importance of inclusivity, stating that there is room for everyone to contribute, even in a crowded field, and that open communication and trust are paramount. To illustrate this, he shared his own transition to independence within a seemingly saturated field. While initially working on a different topic, he made a strategic decision to “pivot” to epigenetic mechanisms in Acute Myeloid Leukemia (AML) and TET2 mutations, which were relatively unknown at the time. Driven by his passion for cancer epigenetics and mechanistic biology, he explained that when the right opportunity arises, it becomes apparent. Additionally, he emphasized the significance of having thought partners. These thought partners can be your mentees and postdocs in the lab, who will eventually grow and become more independent. Once they reach that point, Dr. Levine openly discusses various options with trainees and works together to decide which projects they can take with them to establish their own labs. His approach is refreshingly honest and generous, he believes that there will always be other avenues to explore, characteristically saying that “he’ll find something else to do”. Αt the same time, he points out that not all mentors take this approach for various reasons.</span></p><p><span style="font-family: arial;">From Dr. Viny's perspective, he expressed gratitude for his mentor's enthusiasm and support throughout his postdoctoral training. The lab's encouraging environment, combined with Dr. Levine's desire for his mentees' success, played pivotal roles in a productive postdoc experience and a smooth transition to independence. They both emphasized the importance of transparency and respect in the transition process. Dr. Viny also shared his “pivot” moment, seeing previously uncharacterized opportunity to study the role of cohesins in AML, creating his own research niche within the lab.</span></p><p><span style="font-family: arial;">For Dr. Levine, mentoring is a rewarding experience, emphasizing the collective nature of success over individual achievements. He takes great pride in the accomplishments of the researchers he has trained and the impact they have made. He strongly believes that sharing projects, knowledge and collaboration does not hinder progress. What was clear from this discussion is that trainees need to pick their postdoc mentors very carefully and Dr. Levine's honest and supportive approach resonated strongly with the audience of new and junior investigators! The message we were left with was that if we are enthusiastic about our research and focus on the primary goals of curing disease, while ignoring personal accolades, we create a supportive environment that nurtures new investigators, who will continue to be good mentors to the next generation of scientists. </span></p><p><span style="font-family: arial;">While this blog post captures the key messages, we would encourage readers to <a href="https://www.iseh.org/page/ISEHWebinars" target="_blank">watch the webinar recording available free to all ISEH members</a> to learn more about the importance of mentorship.</span></p><p><span style="font-family: arial;"><br /></span></p><p><i><span style="font-family: arial;">Blog post contributed by George Souroullas and Nick Van Gastel from the ISEH Junior Faculty Committee</span></i></p><p><i style="background-color: white; color: #757575; font-family: arial; font-size: 15px;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></p><div><br /></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-1166904265395444172023-09-05T15:06:00.009-05:002023-09-05T15:11:33.961-05:00Setting up a new lab and managing expectations- “Lab-o-poiesis” ala Tina Termini and “A Cynic’s Guide to Starting Up a Lab” by Adrian Liston<p><b><span style="font-family: arial;">Setting up a new lab and managing expectations- “Lab-o-poiesis” ala Tina Termini and “A Cynic’s Guide to Starting Up a Lab” by Adrian Liston</span></b></p><p><span style="font-family: arial;">Starting your independent lab is an exciting time in your career, but it also brings many challenges, including moving to a new institution, managing administrative duties, hiring staff, and balancing new responsibilities all while continuing to advance your science. </span></p><p><span style="font-family: arial;">In the April 2023 Junior Faculty Committee-sponsored webinar, both Dr. Christina Termini, a first-year Principal Investigator (PI) at the Fred Hutch Cancer Center in Seattle, WA, USA, and Prof. Adrian Liston, a senior PI who has led labs at Vlaams Instituut voor Biotechnologie in Belgium, the Babraham Institute in the UK, and now at the University of Cambridge, outlined the challenges faced at different stages of their journeys as independent researchers and how they navigated these. </span></p><p><span style="font-family: arial;">Importantly, several common themes emerged with some important take-home messages that can help you begin your own independent career journey:</span></p><p><b><span style="font-family: arial;">Key Message #1: Running an independent research lab is a marathon, not a sprint.</span></b></p><p><span style="font-family: arial;">It will take time to build a lab and a team and mistakes will be made but there is plenty of support around if you know where to look and who to ask. Time is the scarcest resource! So, begin by fostering relationships and collaboration with your institutional community including reaching out to other PIs, facilities, and human resources early to understand the current policies of the institution you are in and how your institution would expect you to contribute to it. Learn who your helpers are in the business office, shipping, and human resources, because these people will help you navigate many of the initial orders of business you’ll encounter when starting your lab. </span></p><p><span style="font-family: arial;">Engage with other PIs and share experiences on how best to navigate the path to tenure and promotion. Include senior and other junior faculty in your network to get a diversity of perspectives when you have key decisions to make. You should never be alone on your career journey. </span></p><p><b><span style="font-family: arial;">Key Message #2: When hiring new staff – be patient and clear on expectations. </span></b></p><p><span style="font-family: arial;">The second key message from both speakers centered around personnel. Recruitment and retention of good lab personnel are key to a lab’s success. Many of us do not receive formal training in hiring and managing staff during our PhD and Postdoc experiences. Dr. Termini emphasized the usefulness of a strategic plan in which you align projects with personnel, such that you can clearly communicate the needs of the position for which you’re hiring in a well-thought-out job posting. Both Dr. Termini and Dr. Liston agreed: do not rush to hire new people. Take the time to find the right candidates and remember to account for the time and effort each hire will cost you in onboarding and training time. </span></p><p><span style="font-family: arial;">Once the offer is made and your new lab members start to join the team, Dr. Termini recommended reading “Making of a Manager,” “Essentialism,” “The Obstacle is the Way,” and “Crucial Conversations” to supplement our managerial knowledge. Dr. Liston added that the book, “Why Marriages Succeed and Fail and How to Make Yours Last,” has been useful to him because the relationships we build with our lab staff are like a marriage as both require mutual trust and effective communication. </span></p><p><span style="font-family: arial;">Dr. Liston agreed with Dr. Termini that establishing a positive lab culture is also an important step in onboarding new hires. This can be aided by establishing and documenting clear policies and guidelines for the lab and updating them regularly as the lab evolves over time. Additionally, it’s helpful to make clear what your staff’s expectations should be of you.</span></p><p><span style="font-family: arial;">Prof Liston stressed the importance of encouraging and rewarding staff to keep people that contribute well to the team. This can include efforts such as advocating for their promotion or salary increases, remembering that even large salary increases will only have a minor effect on your overall lab budget. This is a smart investment to retain good talent. </span></p><p><span style="font-family: arial;">One of the most difficult tasks for PIs is managing difficult conversations with team members when things are not going as expected. For these crucial conversations, Dr. Liston found success with using “I” language to explain his perspective on an issue. This humanizes both parties and focuses the conversation on solutions rather than blame. Dr. Liston advises new PIs to start with positive feedback, and then raise suggestions for improvement. Make sure to follow up on crucial conversations with written summaries- document everything! He strongly recommends utilizing the probationary period to carefully discern whether a new person will be successful in the lab or should best move on to a new position. This is the easiest time to make personnel changes, and sometimes you will have to make the hard decision of not keeping a lab member. </span></p><p><b><span style="font-family: arial;">Key Message #3: Organize the lab and prioritize your science. </span></b></p><p><span style="font-family: arial;">As a tenure-track assistant professor, conducting and disseminating your research should be at the forefront of your priorities. You probably already have a clear vision of what you want to achieve and how you plan to get there after writing your research statement. However, budgeting time and money are critical skills for successfully running an independent research lab. Dr. Termini advises getting more granular and planning out the order in which you will conduct the first few sets of experiments in the new lab. Review the protocols for those experiments and make lists of all the equipment and reagents needed to complete them. Then you can strategically order everything you need to initiate research in your new lab. </span></p><p><span style="font-family: arial;">Concomitant with this is having a plan for your space to ensure that you can fit your equipment and materials and have proper storage environments ready to receive your orders and facilitate your experiments. Speaking to the importance of having a well-organized lab space, Dr. Termini has coined #TheLabEdit on Twitter and shares many of her pro-tips for organizing the physical inventory in the lab and establishing a productive space with easy access to necessary experimental materials. She also advises planning for effective communication strategies, data management, and storage (i.e., through Microsoft Teams, Slack, or similar tools) so that newly generated data can be easily shared and accessed by lab members and preserved for publication and archival purposes. Collaborations can be very helpful for moving projects forward but can also be a huge cost on time and money if the collaboration is too one-sided. Choose collaborators wisely. Dr. Liston encouraged people not to hoard, but rather to spend their start-up packages to generate research products, like conference abstracts, grant applications, and manuscripts for publication. Use connections and resources at your institution to get discounts from vendors, even a 10-20% discount on orders really adds up! Dr. Liston advises against new PIs budgeting too much time for service (committees, reviewers, etc.). Instead, he encourages new PIs to ringfence substantial amounts of time to focus their time on thinking, writing, managing, and producing preliminary data because publications and grants are key to tenure and promotion. Ideally, new PIs should plan to write 2-3 grants per year, spending 3-6 months on writing, editing, and submitting. </span></p><p><span style="font-family: arial;">In summary, being a tenure-track assistant professor is an exciting but challenging phase of your career. We hope these key messages on starting a new research lab will help you navigate this phase successfully and achieve your research and career goals. Good luck!</span></p><p><span style="font-family: arial;">We would like to thank our speakers Dr Christina Termini and Professor Adam Liston for sharing their experience.</span></p><p><i><span style="font-family: arial;">The Junior PI webinar series is freely available for all ISEH members on the webinar page of the ISEH website. </span></i></p><p><i><span style="font-family: arial;"><br /></span></i></p><p><i><span style="font-family: arial;">Blog post contributed by Vanessa Scanlon from the ISEH Junior Faculty Committee</span></i></p><p><i style="background-color: white; color: #757575; font-family: arial; font-size: 15px;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></p><div><br style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;" /></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-38412803916011422922023-08-19T06:04:00.001-05:002023-08-19T06:04:58.652-05:00Thank You 2023 Sponsors and Exhibitors!<p> </p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiHZ5Q8MRbFDRnv4U7AiTRQSA48rtwa0d2zSchQFkiB4GfgZ-gpVdSKh-WXarvm7SyMKYMyDrioU4FkrqjyhuWKWn6bZMQlXxpki74BDFzHUKIRQYVvp7rM-yuxqumysccQ-9as_twDyLTdYKBj3TFJhi2UZyHHKqIwf1lnvZFbkYnoH3n-xRKF2WtRVMpJ/s1125/ISEH_931054-22_AM2023_WB_1125x360_1.png" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="360" data-original-width="1125" height="203" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiHZ5Q8MRbFDRnv4U7AiTRQSA48rtwa0d2zSchQFkiB4GfgZ-gpVdSKh-WXarvm7SyMKYMyDrioU4FkrqjyhuWKWn6bZMQlXxpki74BDFzHUKIRQYVvp7rM-yuxqumysccQ-9as_twDyLTdYKBj3TFJhi2UZyHHKqIwf1lnvZFbkYnoH3n-xRKF2WtRVMpJ/w640-h203/ISEH_931054-22_AM2023_WB_1125x360_1.png" width="640" /></a></div><p></p><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1690301559103-600" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1690301559146-914" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="text text--padding-vertical" data-cpeid="w-1690301559183-201" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="left" class="text_content-cell content-padding-horizontal" style="-webkit-font-smoothing: antialiased; display: block; line-height: 1.2; overflow-wrap: break-word; padding: 10px 20px;" valign="top"><p align="center" style="color: #00111d; font-size: 14px; margin: 0px; padding: 0px; text-align: center;"><span style="color: #25408f; font-family: arial; font-size: 18px; font-weight: bold;">Thank You Sponsors & Exhibitors</span></p><div style="margin: 0px; padding: 0px; text-align: left;"><span style="font-family: arial;"><span style="color: #25408f; font-size: 18px; font-weight: bold;"><br /></span><span face="Arial, Verdana, Helvetica, sans-serif" style="color: #00111d;"><span style="font-size: 14px;">The 52nd Annual Scientific Meeting of the International Society for Experimental Hematology meeting is taking place now in New York City, United States. The exciting program (<a href="https://www.iseh.org/ISEH2023">https://www.iseh.org/ISEH2023</a>) includes career and technology sessions, as well as talks and poster presentations from trainees, new investigators and leaders in the field.</span></span><span face="Arial, Verdana, Helvetica, sans-serif" style="color: #00111d;"><span style="font-size: 14px;"><br /></span></span><span face="Arial, Verdana, Helvetica, sans-serif" style="color: #00111d;"><span style="font-size: 14px;">On behalf of the ISEH Board of Directors, volunteers and staff, we'd like to thank our 2023 sponsors and exhibitors, seen below. We hope to see you all again in 2024!</span></span></span></div><p style="margin: 0px; padding: 0px; text-align: left;"><span face="Arial, Verdana, Helvetica, sans-serif" style="color: #00111d;"><span style="font-family: arial; font-size: 14px;"><br /></span></span></p><p style="color: #00111d; font-size: 14px; margin: 0px; padding: 0px;"><span style="font-family: arial;">Funding for this conference was made possible (in part) by R13HL170705 from the <span style="font-weight: bold;">National Heart Lung and Blood Institute (NHLBI)</span>. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.</span></p><p style="color: #00111d; font-size: 14px; margin: 0px; padding: 0px;"><span style="font-family: arial;"> </span></p><p align="center" style="color: #00111d; font-size: 14px; margin: 0px; padding: 0px; text-align: center;"><span style="font-family: arial;">This program is supported by an independent medical education grant from <span style="font-weight: bold;">Pfizer</span>.</span></p></td></tr></tbody></table></td></tr></tbody></table><table bgcolor="#f5f5f5" border="0" cellpadding="0" cellspacing="0" class="layout layout--feature layout--1-column" data-cpeid="w-1691514295445-241" style="background-color: whitesmoke; color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691514295445-528" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="text text--feature text--padding-vertical" data-cpeid="w-1691514295445-822" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="text_content-cell content-padding-horizontal" style="-webkit-font-smoothing: antialiased; color: #403f42; display: block; font-family: Arial, Verdana, Helvetica, sans-serif; font-size: 14px; line-height: 1.2; overflow-wrap: break-word; padding: 10px 20px; text-align: center;" valign="top"><h1 style="color: white; font-size: 24px; margin: 0px;"><span style="color: #86ca97; font-size: 20px;">Platinum</span></h1></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691513081154-877" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691513081181-235" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--padding-vertical image--mobile-scale image--mobile-center" data-cpeid="w-1691512885797-766" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding: 10px 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/b69119b8-040c-4ec4-b36b-85958d1a6146.png?rdr=true" style="display: block; height: auto; max-width: 100%;" width="329" /></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--2-column" data-cpeid="w-1691512885797-399" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691512885797-658" style="width: 310px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691512885797-520" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding-left: 20px; padding-right: 10px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/70570ee8-86cf-4d2a-b95c-4a0bd70722ea.jpg?rdr=true" style="display: block; height: auto; max-width: 100%;" width="251" /></td></tr></tbody></table></td><td align="center" class="column column--2 scale stack" data-cpeid="w-1691512885797-768" style="width: 310px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--padding-vertical image--mobile-scale image--mobile-center" data-cpeid="w-1691512885797-753" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding: 10px 20px 10px 10px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/844698ca-69e2-4096-a304-3672070b5d88.png?rdr=true" style="display: block; height: auto; max-width: 100%;" width="253" /></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691513423491-558" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691513423521-255" style="width: 620px;" valign="top"><div class="spacer" data-cpeid="w-1691513423558-881" style="height: 10px; line-height: 10px;"> </div></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691513130770-316" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691513130797-703" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="text text--padding-vertical" data-cpeid="w-1691513130826-849" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="left" class="text_content-cell content-padding-horizontal" style="-webkit-font-smoothing: antialiased; color: #00111d; display: block; font-family: Arial, Verdana, Helvetica, sans-serif; font-size: 14px; line-height: 1.2; overflow-wrap: break-word; padding: 10px 20px;" valign="top"><p align="center" style="margin: 0px; padding: 0px; text-align: center;"><span style="color: #86ca97; font-size: 20px; font-weight: bold;">Gold</span></p></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--2-column" data-cpeid="w-1691513156403-723" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691513156403-348" style="width: 279px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691513156403-902" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="right" class="image_container content-padding-horizontal" style="padding-left: 20px; padding-right: 10px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/90323907-0a7c-4dca-aea0-dc231385dee1.jpg?rdr=true" style="display: block; height: auto; max-width: 100%;" width="198" /></td></tr></tbody></table></td><td align="center" class="column column--2 scale stack" data-cpeid="w-1691513156403-308" style="width: 341px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691513156403-441" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="left" class="image_container content-padding-horizontal" style="padding-left: 10px; padding-right: 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/751f1f5d-0422-458d-b069-c06f34cfc05e.jpg?rdr=true" style="display: block; height: auto; max-width: 100%;" width="230" /></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691513301011-460" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691513301041-342" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691513156403-814" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding-left: 20px; padding-right: 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/cdfe7c22-ce9c-40be-aa35-4f3003320e89.png?rdr=true" style="display: block; height: auto; max-width: 100%;" width="368" /></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691513430804-312" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691513430836-568" style="width: 620px;" valign="top"><div class="spacer" data-cpeid="w-1691513430869-672" style="height: 10px; line-height: 10px;"> </div></td></tr></tbody></table><table bgcolor="#f5f5f5" border="0" cellpadding="0" cellspacing="0" class="layout layout--feature layout--1-column" data-cpeid="w-1691514315650-628" style="background-color: whitesmoke; color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691514315650-662" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="text text--feature text--padding-vertical" data-cpeid="w-1691514315650-362" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="text_content-cell content-padding-horizontal" style="-webkit-font-smoothing: antialiased; color: #403f42; display: block; font-family: Arial, Verdana, Helvetica, sans-serif; font-size: 14px; line-height: 1.2; overflow-wrap: break-word; padding: 10px 20px; text-align: center;" valign="top"><h1 style="color: white; font-size: 24px; margin: 0px;"><span style="color: #86ca97; font-size: 20px;">Silver</span></h1></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691857587071-742" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691857587071-506" style="width: 310px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--padding-vertical image--mobile-scale image--mobile-center" data-cpeid="w-1691513381098-283" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding: 10px 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/abb3dc44-b44f-4b8f-b688-b61917fc5457.jpg?rdr=true" style="display: block; height: auto; max-width: 100%;" width="270" /></td></tr></tbody></table></td><td align="center" class="column column--1 scale stack" data-cpeid="w-1691857587071-737" style="width: 310px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--padding-vertical image--mobile-scale image--mobile-center" data-cpeid="w-1691857553061-715" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding: 10px 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/85c7cf71-e82b-46cf-95a8-4481be2789c3.png?rdr=true" style="display: block; height: auto; max-width: 100%;" width="200" /></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691514345747-656" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691514345793-143" style="width: 620px;" valign="top"><div class="spacer" data-cpeid="w-1691514345838-531" style="height: 10px; line-height: 10px;"> </div></td></tr></tbody></table><table bgcolor="#f5f5f5" border="0" cellpadding="0" cellspacing="0" class="layout layout--feature layout--1-column" data-cpeid="w-1691514334928-523" style="background-color: whitesmoke; color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691514334928-341" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="text text--feature text--padding-vertical" data-cpeid="w-1691514334928-324" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="text_content-cell content-padding-horizontal" style="-webkit-font-smoothing: antialiased; color: #403f42; display: block; font-family: Arial, Verdana, Helvetica, sans-serif; font-size: 14px; line-height: 1.2; overflow-wrap: break-word; padding: 10px 20px; text-align: center;" valign="top"><h1 style="color: white; font-size: 24px; margin: 0px;"><span style="color: #86ca97; font-size: 20px;">Bronze</span></h1></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--3-column" data-cpeid="w-1691513514634-265" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691513514633-240" style="width: 206.656px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691513514633-482" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding-left: 20px; padding-right: 0px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/54b4d775-fe0f-4d8c-9844-7b5f6cd466bf.png?rdr=true" style="display: block; height: auto; max-width: 100%;" width="160" /></td></tr></tbody></table></td><td align="center" class="column column--2 scale stack" data-cpeid="w-1691513514633-443" style="width: 206.656px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691513514633-425" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding-left: 10px; padding-right: 10px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/ae881625-d503-4dfa-983b-b676b992e0d1.png?rdr=true" style="display: block; height: auto; max-width: 100%;" width="160" /></td></tr></tbody></table></td><td align="center" class="column column--3 scale stack" data-cpeid="w-1691513514634-951" style="width: 206.688px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--padding-vertical image--mobile-scale image--mobile-center" data-cpeid="w-1691513514634-252" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding: 10px 20px 10px 0px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/03d372d4-716b-48f7-8a1b-2018cc98a161.jpg?rdr=true" style="display: block; height: auto; max-width: 100%;" width="160" /></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--2-column" data-cpeid="w-1691513679806-758" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691513679806-306" style="width: 310px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691513679806-511" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="right" class="image_container content-padding-horizontal" style="padding-left: 20px; padding-right: 10px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/46f63235-4253-4b23-a3c8-ad65b30f6522.jpg?rdr=true" style="display: block; height: auto; max-width: 100%;" width="148" /></td></tr></tbody></table></td><td align="center" class="column column--2 scale stack" data-cpeid="w-1691513679806-525" style="width: 310px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691513679806-818" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="left" class="image_container content-padding-horizontal" style="padding-left: 10px; padding-right: 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/49c2ea34-f291-4803-98b8-e0867e022b7e.jpg?rdr=true" style="display: block; height: auto; max-width: 100%;" width="194" /></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691513717392-442" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691513717426-934" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691513679806-553" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding-left: 20px; padding-right: 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/ee04cb04-8f12-436b-a17b-7a668807bb8d.png?rdr=true" style="display: block; height: auto; max-width: 100%;" width="271" /></td></tr></tbody></table></td></tr></tbody></table><table bgcolor="#f5f5f5" border="0" cellpadding="0" cellspacing="0" class="layout layout--feature layout--1-column" data-cpeid="w-1691514370695-217" style="background-color: whitesmoke; color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691514370695-341" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="text text--feature text--padding-vertical" data-cpeid="w-1691514370695-840" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="text_content-cell content-padding-horizontal" style="-webkit-font-smoothing: antialiased; color: #403f42; display: block; font-family: Arial, Verdana, Helvetica, sans-serif; font-size: 14px; line-height: 1.2; overflow-wrap: break-word; padding: 10px 20px; text-align: center;" valign="top"><h1 style="color: white; font-size: 24px; margin: 0px;"><span style="color: #86ca97; font-size: 20px;">Educational Supporters</span></h1></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691514390642-516" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691514390682-170" style="width: 620px;" valign="top"><div class="spacer" data-cpeid="w-1691514390726-656" style="height: 10px; line-height: 10px;"> </div></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691513864575-965" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691513864574-236" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691513864574-336" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding-left: 20px; padding-right: 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/677344a9-0d73-4da3-9e64-034628c75d45.jpg?rdr=true" style="display: block; height: auto; max-width: 100%;" width="329" /></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--2-column" data-cpeid="w-1691514101232-411" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691514101232-913" style="width: 310px;" valign="top"><div class="spacer" data-cpeid="w-1691514161660-635" style="height: 40px; line-height: 40px;"> </div><table border="0" cellpadding="0" cellspacing="0" class="image image--padding-vertical image--mobile-scale image--mobile-center" data-cpeid="w-1691514101232-796" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="right" class="image_container content-padding-horizontal" style="padding: 10px 10px 10px 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/acc04c78-79f4-47e2-a60b-eaaa44c6c93e.png?rdr=true" style="display: block; height: auto; max-width: 100%;" width="161" /></td></tr></tbody></table></td><td align="center" class="column column--2 scale stack" data-cpeid="w-1691514101232-733" style="width: 310px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691514101232-458" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="left" class="image_container content-padding-horizontal" style="padding-left: 10px; padding-right: 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/64d9b19f-9eff-47f6-9efd-5bb4bf932d6b.png?rdr=true" style="display: block; height: auto; max-width: 100%;" width="142" /></td></tr></tbody></table></td></tr></tbody></table><table border="0" cellpadding="0" cellspacing="0" class="layout layout--1-column" data-cpeid="w-1691514125777-820" style="color: black; min-width: 100%; table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="column column--1 scale stack" data-cpeid="w-1691514125818-809" style="width: 620px;" valign="top"><table border="0" cellpadding="0" cellspacing="0" class="image image--mobile-scale image--mobile-center" data-cpeid="w-1691514101232-125" style="table-layout: fixed; width: 100%;"><tbody><tr><td align="center" class="image_container content-padding-horizontal" style="padding-left: 20px; padding-right: 20px;" valign="top"><img alt="" class="image_content" data-image-content="" src="https://files.constantcontact.com/37e4e993601/55ecfab4-352e-4e33-b4d7-41e32fa88e45.jpg?rdr=true" style="display: block; height: auto; max-width: 100%;" width="310" /></td></tr></tbody></table></td></tr></tbody></table>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-12665914253926663092023-04-13T11:18:00.005-05:002023-04-13T11:18:44.667-05:00Lab Spotlight: Helgason Lab<div class="separator"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEikumOxFkBxc66ANhzxw6upK-55rslxKV7ilxZAOpNWmmbe9NCyaPr1ztJySRe-OtUyorgWwPh8oFQ7LAI2PiciURoRr1rRkQSrO8CzVt-8XBCfOWAAL2udW5-Zwc6FPdS8fx_8J346X5jR2qbNnXZiTby8hRjPjlFeN8XH3YS3OcRYW7MtTd_xm8TDLw/s2448/picture%20Helgason%20lab.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em; text-align: center;"><img border="0" data-original-height="1592" data-original-width="2448" height="416" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEikumOxFkBxc66ANhzxw6upK-55rslxKV7ilxZAOpNWmmbe9NCyaPr1ztJySRe-OtUyorgWwPh8oFQ7LAI2PiciURoRr1rRkQSrO8CzVt-8XBCfOWAAL2udW5-Zwc6FPdS8fx_8J346X5jR2qbNnXZiTby8hRjPjlFeN8XH3YS3OcRYW7MtTd_xm8TDLw/w640-h416/picture%20Helgason%20lab.jpg" width="640" /></a></div><br /><b> Lab Spotlight Vignir Helgason, School of Cancer Sciences, University of Glasgow<br /></b><br />Each month, Simply Blood spotlights a lab focused on the research of basic hematology, immunology, stem cell research, cell and gene therapy, and other related aspects. Get to know these different labs around the world! This month, we are featuring the Helgasson Lab at the School of Cancer Sciences at the University of Glasgow!<br /><br /><b>What is the research focus of your lab?</b><br /><i>My lab focuses on basic cellular processes such as autophagy and metabolism in leukaemia. We are trying to exploit vulnerabilities in these processes and identify ways to develops better treatment options.</i><br /><br /><b>Did you plan your career and how did it develop?</b><br /><i>No, to be honest, I never really had a master plan for my career. However, I was always good in seeking advice from people who could help me achieve my goals. <br /><br />During my studies at the University of Iceland, deCODE Genetics, a biopharmaceutical company based in Reykjavik, was founded, and offered a lot of interesting jobs, so I decided to take additional modules in molecular and cell biology at university and applied for a job with them after my degree BSc graduation. I really enjoyed the work at deCODE, which was mainly cell biology based. I had team members that had completed a Ph.D. and they liked my work attributes and encouraged me to apply for Ph.D. positions, mainly in the U.K. given the great reputation of British Universities. Initially, my plan was to go back to Iceland afterwards. However, I really enjoyed my Ph.D. journey in Prof Kevin Ryan’s laboratory at the Cancer Research UK Beatson Institute in Glasgow, U.K. and became even more interested in cell biology, cancer and autophagy. After my Ph.D. I explored my options, mainly in the U.K. again. There was an opening in Prof. Tessa Holyoake’s laboratory at the Paul O’Gorman Leukemia Centre in Glasgow and after an informal meeting with Tessa, I was inspired by her research and felt she would be a great mentor. Tessa aimed to recruit someone who could work independently, and with inner drive to achieve, and thought I would fit the bill, so I started working with Tessa on CML. Tessa was obviously well known for her outstanding translational work in CML. She was also a very engaging character and inspired me to go down the path of research with an orientation towards translation in leukaemia. During my post-doc I combined my interest in autophagy and cancer, creating my own research niche. Based on a collaboration with Prof Calabretta’s group (Philadelphia) and my results, Tessa received funding to start a clinical trial with autophagy inhibitors in CML. That was very exciting and really motivated me to continue in academia.<br /><br />I next decided to start my path towards independence and applied for fellowships to start my own lab. In 2013 I received a Kay Kendall Intermediate Fellowship which kick started my independent career. Again, I received a lot of help from senior PIs at the Cancer Centre in Glasgow. So, although I never really planned to become a group leader, it somehow happened, and it really is something I enjoy and am grateful for.</i><br /><br /><b>Did you have a plan B in case your academic research did not follow through?</b><br /><i>Yes, I did. I had worked in a company and enjoyed working in industry, so this was always my plan B. In general, I think it is always good to have a plan B so you are not setting yourself up for disappointment, but also so you are not restricting yourself in your development and can seek opportunities where they arise!</i><br /><br /><b>Any tips for running a successful group?</b><br /><i>Apart from being open to acknowledge your limitations and not being shy to seek help where needed, resilience is very important. Not every project or grant application you submit will be successful, so you have to find a way to deal with drawbacks. Being a people’s person helps. In my case, it allowed me to build up a dynamic and enthusiastic research team, but also helped to initiate and maintain fruitful collaborations. I also encouraged the people in my group to create space to develop their own ideas and drive aspects of their research forward, and this has really paid off. I think about my team’s culture and put a lot of effort into the recruitment process to ensure I recruit the right people for my lab and ensure diversity.</i><br /><br /><b>What is the most exciting project in the lab right now?</b><br /><i>I don’t have a particular favorite, but I like the way we try to understand basic molecular functions, such as autophagy and more recently metabolism, clinically relevant cell population, that is in the leukemic stem cells. We also started to explore the role of the microenvironment/immune cells in leukaemia and again, this has led to lots of new findings and ideas.</i><br /><br /><b>How does your lab celebrate accomplishments?</b><br /><i>We usually have a cake in the office and then go to the pub followed by dinner. It is important to celebrate small and big victories to keep everyone motivated, but also to create an atmosphere where people can connect on a personal level, enjoy themselves and relax.</i><br /><br /><b>Does your lab have any traditions?</b><br /><i>We don’t have any tradition as such that I can remember, but given we are 13 different nationalities in the lab, we have friendly debates about which country ranks the highest for the best cuisine. I am really proud of the fact we are so diverse and can learn from each other about culture and food, but also ways of life and ways of thinking. This is one of the most fun aspects of science - it is very international.</i><br /><br /><b>Vignir Helgason, Ph.D.<br /></b>Leukaemia and Autophagy Therapeutics<br />School of Cancer Sciences, University of Glasgow, U.K.<br /><a href="https://www.gla.ac.uk/schools/cancersciences/staff/vignirhelgason/">https://www.gla.ac.uk/schools/cancersciences/staff/vignirhelgason/</a><br /><div><br /></div><div><div style="background-color: white;"><span style="color: #666666; font-family: arial; font-size: 15px;"><i>Blog post contributed by: <b>Kristina Kirschner </b>(</i></span><span style="background-color: transparent; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i>@krikirschner)</i></span></span><i style="color: #666666; font-family: arial; font-size: 15px;">, ISEH Publications Committee</i></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i style="color: #757575;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></span></div></div><div class="separator" style="clear: both; text-align: center;"><br /></div><br />ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-27991494851921674682023-04-06T11:05:00.002-05:002023-04-06T13:35:08.651-05:00ISEH 2023 Virtual Career Fair<div class="separator" style="text-align: left;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiE-l3ZMe9ysz2UQ-xyFW9osl4tVUI4GvMsP3Mg6EGEGFrYi0PMUKYAhHm9o7r3MGkasDI2kDslEbAXN-3sKBvlpL_X2tMy4ZYi9SDLIVvIDdz679ZM63sO3TmztueWRVtbWUPHyuMcMiRoma9iNuHFtlszgjkSh0T_WFC_eZGdRpCmucP1jw3jAnpMDA/s600/2023%20Career%20Fair%20Email%20Header%20(600%C3%97200).png" style="margin-left: 1em; margin-right: 1em; text-align: center;"><img border="0" data-original-height="200" data-original-width="600" height="214" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiE-l3ZMe9ysz2UQ-xyFW9osl4tVUI4GvMsP3Mg6EGEGFrYi0PMUKYAhHm9o7r3MGkasDI2kDslEbAXN-3sKBvlpL_X2tMy4ZYi9SDLIVvIDdz679ZM63sO3TmztueWRVtbWUPHyuMcMiRoma9iNuHFtlszgjkSh0T_WFC_eZGdRpCmucP1jw3jAnpMDA/w640-h214/2023%20Career%20Fair%20Email%20Header%20(600%C3%97200).png" width="640" /></a></div><div style="text-align: center;"><br /></div><span style="font-family: arial;">Finding the postdoc position that best fits the next step in your career can be a challenge. To help put great trainees in touch with great faculty providing postdoc opportunities, the ISEH New Investigator Committee has put together the <a href="https://www.iseh.org/page/CareerFair2023">ISEH 2023 Virtual Career Fair</a>. This live and interactive career fair will be held on Tuesday, 18 April 2023 from 15:00-17:00 CDT (<a href="https://www.timeanddate.com/worldclock/fixedtime.html?msg=ISEH+2023+Virtual+Career+Fair&iso=20230418T15&p1=64&ah=2">click here to see in your time zone</a>). <br /><br />This event is <b>FREE for all PhD students and postdocs</b>! You do not need to be an ISEH member. <br /><br /><a href="https://www.iseh.org/page/CareerFair2023">Click here to register</a>. </span><div><span style="font-family: arial;"><br /><b><i>What is it? <br /></i></b><br />Participants will be sent a link to an online networking platform. This places you inside a virtual room, with each hiring PI seated at their own table. You can join a table to talk with the PI and other trainees there. <br /><br />This provides the perfect opportunity to introduce yourself, why you are interested in a position in their laboratory, and how you could be a good fit in their team. <br />You will be free to move to other tables throughout the duration of the event. <br /><br /><b><i>Who is hiring? <br /></i></b><br />This career fair promises participation from up to 50 hiring labs and industry partners, including:<br /><b>Marjorie Brand</b> (University of Wisconsin in Madison, USA)<br /><b>Lee Grimes</b> (Cincinnati Children's Hospital, USA)<br /><b>Mick Milsom</b> (HI-STEM gGmbH, Germany)<br /><b>Katrin Ottersbach</b> (University of Edinburgh, UK)<br /><b>Toshio Suda</b> (Keio University, Japan)<br /><b>Jennifer Trowbridge</b> (The Jackson Laboratory, USA)<br /><b>Peter van Galen </b>(Harvard Stem Cell Institute, USA) <br /><br /><b><i>Why should I participate?<br /></i></b><br />Connecting with multiple high profile hiring labs from all over the world from the comfort of your desk is convenient, accessible and efficient. <br /><br />Here is what attendees said about the 2022 ISEH Virtual Career Fair:<br /></span><blockquote style="border: none; margin: 0px 0px 0px 40px; padding: 0px; text-align: left;"></blockquote><i style="font-family: arial;">Meeting a variety of PIs at the ISEH Virtual Career Fair was great. Even better was meeting like-minded researchers who have gone on to become friends. We now run into each other at conferences and have introduced each other to our networks. I'd recommend the ISEH career fair to anyone looking for their next postdoc, or just to network.</i><br /><span style="font-family: arial;">-- Chris Mapperley, Queen Mary University of London</span><span style="font-family: arial;"><blockquote style="border: none; margin: 0px 0px 0px 40px; padding: 0px; text-align: left;"></blockquote><br /><blockquote style="border: none; margin: 0px 0px 0px 40px; padding: 0px; text-align: left;"></blockquote><i>The ISEH Virtual Career Fair was an incredibly well organised and easy networking event to attend. It was wonderful to be able to meet researchers from across the globe all in one space without the hassle (and cost!) of international travel. I found it an invaluable event in starting my search for a post-doc position.</i><br /><span style="font-family: arial;">-- Elizabeth Lieschke, Walter and Eliza Hall Institute, Melbourne</span></span></div><div><span style="font-family: arial;"><span style="font-family: arial;"></span></span><span style="font-family: arial;"><br /><i><b>How do I get the most out of the Career Fair? <br /></b></i><br /><b>Do your research. </b>Take some time to research the companies that will be participating. This will help you to identify who you are most interested in and to prepare questions that you can ask.</span></div><div><span style="font-family: arial;"><br /><b>Have your elevator pitch ready.</b> Be prepared to clearly and concise describe why you are interested in a position, and why you’d be a good fit. It’s also an advantage to have an up-to-date CV ready to share. <br /><br /><b>Be ready to follow up</b>. If you are interested in a postdoc position that you discussed at the fair, take the initiative and contact the PI again to continue the discussion. <br /><br /><a href="https://www.iseh.org/page/CareerFair2023">Register now!</a></span><body lang="EN-US" link="#0563C1" style="word-wrap: break-word;" vlink="#954F72">
</body><div><br /></div><div><br /></div><div><div style="background-color: white;"><div style="color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i>Blog post contributed by members of the ISEH New Investigators Committee:</i></span></div><div><span style="color: #757575; font-family: arial; font-size: 15px;"><span face="Arial, Tahoma, Helvetica, FreeSans, sans-serif"><i>Stephen Loughran, PhD - </i></span></span><span style="color: #757575; font-family: arial;"><span style="font-size: 15px;"><i>@StephenLoughran</i></span></span></div><div style="color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i>Camille Malouf, PhD - </i></span>@camille_malouf</div><div style="color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><i style="font-family: arial;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></div></div><br /></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-84528012728631344522023-03-23T10:07:00.000-05:002023-03-23T10:07:59.300-05:00ISEH 2023 Scientific Award Winners<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi_jaQagLHAgpLmOM_fgkgbetvrZv0aggB2mJHJvBGV8da9rF1bJTjvHwID5IX-iUNmGY2s31BAGwRAGFXBGGE9MdpFMGcHYL6W7dIKmw5gietgQkzdHJd2wHKkGYqNDHJN13oZeHs-sXLKeYdxEXc1s_KjRtlQebxFcIKde16AAt6lcQN2G7_Ypb7yCQ/s2240/ISEH%202023%20Society%20Scientific%20Award%20Winners.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1260" data-original-width="2240" height="225" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi_jaQagLHAgpLmOM_fgkgbetvrZv0aggB2mJHJvBGV8da9rF1bJTjvHwID5IX-iUNmGY2s31BAGwRAGFXBGGE9MdpFMGcHYL6W7dIKmw5gietgQkzdHJd2wHKkGYqNDHJN13oZeHs-sXLKeYdxEXc1s_KjRtlQebxFcIKde16AAt6lcQN2G7_Ypb7yCQ/w400-h225/ISEH%202023%20Society%20Scientific%20Award%20Winners.png" width="400" /></a></div><span style="font-family: arial;"><br />On behalf of the Awards Committee, ISEH would like to congratulate the recipients of the 2023 ISEH Society Scientific Awards, which will be presented at the <a href="https://www.iseh.org/page/ISEH2023"><span style="color: #97002e;">ISEH 52nd Annual Scientific Meeting</span></a>.<br /><br /><b>Donald Metcalf Award Winner – Margaret (“Peggy”) A. Goodell</b></span><div><span style="font-family: arial;"><b><br /></b><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjLiTBVKhfZNMcklXo-lJdbpoKKsnJHM1imBCEg93AG3xFWXwrXKmiaZ2xf-YV_sG5vO_04WdslRO9cEI5P-OF7KxRVdKne8AU1MmPk_eDuKnj6Y8Uq5hyF9KzXwWycO2LVuSof1SxaIaYJbXGPUud6H1ZQdVtmgnK8ArIzT_yvw1j8pWz695ZWOjpe9A/s800/3.png" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="800" data-original-width="800" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjLiTBVKhfZNMcklXo-lJdbpoKKsnJHM1imBCEg93AG3xFWXwrXKmiaZ2xf-YV_sG5vO_04WdslRO9cEI5P-OF7KxRVdKne8AU1MmPk_eDuKnj6Y8Uq5hyF9KzXwWycO2LVuSof1SxaIaYJbXGPUud6H1ZQdVtmgnK8ArIzT_yvw1j8pWz695ZWOjpe9A/w200-h200/3.png" width="200" /></a></div>This year, the 2023 Donald Metcalf Award goes to Dr. Margaret “Peggy” Goodell, who currently serves as the Chair of the Department of Molecular and Cellular Biology, the Vivian L. Smith Chair of Regenerative Medicine, directs and founded the Stem Cells and Regenerative (STaR) Center, and serves as a Professor of Molecular and Cellular Biology, Molecular and Human Genetics, Pediatrics, and Pathology and Immunology at Baylor College of Medicine. Dr. Goodell has served as a faculty member at Baylor completing her doctoral training at the University of Cambridge with Andrew Smith and completed postdoctoral fellowships at Whitehead Institute at MIT and Harvard Medical School, under the guidance of Richard C. Mulligan. She was elected to the National Academy of Medicine in 2019. Dr. Goodell is an internationally recognized leader in the field of hematopoietic stem cell (HSC) biology, and is well known for her discovery and description of novel methodologies to identity long-term and radiation resistant HSC populations capable fully repopulating the adult bone marrow. Her recent work describing the Epigenetic regulation of stem cell has continued her record of performing and publishing science of the highest quality. Her work is cited by innumerable scientists to isolate and study normal and cancer stem cells.<br /><br />Dr. Goodell is an active member of editorial board of Aging and Cancer and Cancer Cell, a past President of ISEH, and has received numerous awards for her professional service and scientific achievement. A mainstay at Baylor college of Medicine for the past 25 years, Dr. Goodell is a paragon within the field of HSC biology and exactly the type of outstanding scientist meant to be honored by the Donald Metcalf award. <br /><br /><b>McCulloch and Till Award Winner – Daniel Starczynowski</b></span></div><div><span style="font-family: arial;"><b><br /></b><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjC8T5Ejf86onWFYjRNxWQ8arek1EXxUsOWkpDPPq3AzesvJTmMd6oOs8nwV21G_Y2crrFixo7Z8r02EVochE22WJKXivntwke8j9wo0aYbrDw1xAmcMh12wfupoBSUy5f-2FWburGe0Gsxn0II759Pryv3fqe2huZKnJGBEdil0iIsoeGxLTkJJujmbg/s800/4.png" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="800" data-original-width="800" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjC8T5Ejf86onWFYjRNxWQ8arek1EXxUsOWkpDPPq3AzesvJTmMd6oOs8nwV21G_Y2crrFixo7Z8r02EVochE22WJKXivntwke8j9wo0aYbrDw1xAmcMh12wfupoBSUy5f-2FWburGe0Gsxn0II759Pryv3fqe2huZKnJGBEdil0iIsoeGxLTkJJujmbg/w200-h200/4.png" width="200" /></a></div>This year’s recipient of the McCulloch and Till Award is Dr. Daniel Starczynowski. Dr. Starczynowski has made seminal contributions to our understanding of how alterations in innate immune signaling and inflammation drive the development of myeloid neoplasms such as myelodysplastic syndrome (MDS). Currently based at the Cincinnati Children’s Hospital Medical Center, Dr. Starczynowski earned his PhD in molecular biology from Boston University under the supervision of Dr. Thomas Gilmore. While in the Gilmore Lab, Dr. Starczynowski studied the role of NF-kB in lymphomagenesis. His postdoctoral years were spent in the laboratory of Dr. Aly Karsan at the BC Cancer Research Centre at the University of British Columbia where he worked on identifying and characterizing novel candidate genes important to the development of MDS and acute myeloid leukemia. His current research interests focus on understanding how genetic changes and altered immune-related pathways play into the development of these cancers while seeking novel therapeutic strategies. <br /><br />In addition to being an active member of the ISEH community, Dr. Starczynowski serves in a number of leadership roles including as the Co-Leader of the Hematologic Malignancies Program at Cincinnati Children’s Hospital, Associate Director for Basic Research in the University of Cincinnati Cancer Center, Chief Scientific Officer for Cincinnati Children’s Hospital’s Innovation Ventures and Chair of the Scientific Advisory Board at Kurome Therapeutics.<br /><br /><b>Janet Rowley Award Winner – Nina Cabezas-Wallscheid</b></span></div><div><span style="font-family: arial;"><b><br /></b><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjWul60aJYvX1yvxQMubjHRy52nRT3JntGkWgsdHw6j4XYlSxqIIl-MVxUM2PS505ACcUMRI5IxXB53gZoAD7oTMhSuxyKlopXdbid-YIC3-MUQBvLk3Do1vd6BV2ik2nrTwjzQW2OwaZOupgHMN_fAca2coe58eiZWLDfzIe8N19lsEPGGZEgqI1ZMAQ/s800/5.png" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="800" data-original-width="800" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjWul60aJYvX1yvxQMubjHRy52nRT3JntGkWgsdHw6j4XYlSxqIIl-MVxUM2PS505ACcUMRI5IxXB53gZoAD7oTMhSuxyKlopXdbid-YIC3-MUQBvLk3Do1vd6BV2ik2nrTwjzQW2OwaZOupgHMN_fAca2coe58eiZWLDfzIe8N19lsEPGGZEgqI1ZMAQ/w200-h200/5.png" width="200" /></a></div>The 2023 recipient of the Janet Rowley Award Winner is Dr. Nina Cabezas-Wallscheid. Nina was awarded her Ph.D. in 2010 from the University of Mainz, for her work with Dr. Ernesto Bockamp on the biology of leukemic stem cells in mouse. Subsequently, she completed a post-doctoral stint in the lab of Prof. Andreas Trumpp at the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM): here Dr. Cabezas-Wallscheid made several seminal discoveries on the biology of quiescence and dormancy of hematopoietic stem cells (HSC), cementing a reputation as a world-class scientist able to combine several experimental approaches targeting proteome, transcriptome and methylome. During her permanence in Heidelberg, Dr. Cabezas-Wallscheid revealed the crucial role of dietary vitamin A in maintaining HSC in a dormant state. Since 2017, she has been group leader in Freiburg, at the Max-Planck Institute of Immunobiology and Epigenetics (MPI-IE). Here, Dr. Cabezas-Wallscheid has been developing her original line of research on HSC dormancy, pursuing projects that mix mouse genetics, human primary samples, and state-of-the-art bioinformatics.<br /><br /> Since 2017, Dr Cabezas-Wallscheid supervised several Ph.D. candidates and master students. Dr. Cabezas-Wallscheid is member of several boards and committees, including the ISEH Board of Directors, the Cell Reports Editorial Board and the Advisory Board for Review Commons. She also organized and chaired several well-known scientific meetings and conferences in the field of hematopoiesis and stem cell biology. Dr. Cabezas-Wallscheid reputation as a rigorous and excellent scientist precede her, and she brilliantly represents the values celebrated by the Janet Rowley award. </span><div><span style="font-family: arial;"><br /></span></div><div><span><a name='more'></a></span><i style="background-color: white; color: #757575; font-family: arial; font-size: 15px;"><br /></i></div><div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i>Blog post contributed by members of the ISEH Publications Committee:</i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><span face="Arial, Tahoma, Helvetica, FreeSans, sans-serif"><i>Alessandro Donada, PhD - </i></span><span style="background-color: transparent; color: black; font-family: "Times New Roman";"><span style="color: #757575; font-family: arial;"><i>@BioRugby</i></span></span></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i>Alyssa Cull, PhD - </i></span><i>@AlyssaHCull</i></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i>Anthony Franchini, PhD </i></span></div></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i><br /></i></span></div><div><i style="background-color: white; color: #757575; font-family: arial; font-size: 15px;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></div></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-36971290280514501072023-03-21T15:42:00.001-05:002023-03-21T15:49:26.875-05:00How we can improve diversity in our research by understanding intersectionality with A/Prof Nada Hamad<span style="font-family: arial;"><div class="separator" style="clear: both; text-align: left;">In undertaking our research, we seek to develop theories and models to help us better understand haematopoiesis and blood related disorders. What is overwhelmingly clear and supported by extensive data is that our research can be improved by increasing both inclusivity and diversity in our workforce<sup>1,2</sup>. When scientists come from diverse backgrounds, they bring with them different experiences, perspectives, and ways of thinking that enrich scientific research. For example, a diverse group of scientists might approach a problem from different angles, or ask different questions, leading to a more comprehensive understanding of the subject. To help us understand more about inclusion and diversity in our own research, the ISEH Junior Faculty Committee asked A/Prof Nada Hamad to help explain the concept of intersectionality.</div><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEitGJZbuZv7ayI4g1UI0cXky882P-KuyGsy2L0e3uB6CsNsEeqXMNxSo8ZOS4d8NVpyEaqCgImpYB8Ly4XslYdoNL7_6SDfc7aWtLBOI3XjgCBHD6YyY-JQ4QQlCSh1GRnOfqJJl-uCrc2S_HqsHYeyn7If-ie9v7UrohNCUR0SJ3hPqy7nmFWSSzQVzA/s1793/Profile%5B94%5D.jpg" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="1793" data-original-width="1483" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEitGJZbuZv7ayI4g1UI0cXky882P-KuyGsy2L0e3uB6CsNsEeqXMNxSo8ZOS4d8NVpyEaqCgImpYB8Ly4XslYdoNL7_6SDfc7aWtLBOI3XjgCBHD6YyY-JQ4QQlCSh1GRnOfqJJl-uCrc2S_HqsHYeyn7If-ie9v7UrohNCUR0SJ3hPqy7nmFWSSzQVzA/w166-h200/Profile%5B94%5D.jpg" width="166" /></a></div>Dr Hamad began the webinar but outlining her personal journey and in particular an event from around 10 years ago for when she had her first child. During labour she was discouraged from having an epidural as the comment was made that “Your people are really good at childbirth, bearing and birthing, and you don't really need it”. Soon Dr Hamad was struggling with so much pain and ended up on the floor but when one of the nurses walked straight past, they just said, “just suck it up. You can do it!”. Some 10 years later and with 3 children, Dr Hamad went to a talk by a black obstetrician who was talking about black women's experiences with childbirth, and how this issue with dismissal of pain and the negative obstetric outcomes for black women was universal and that obstetric outcomes are worse for black women. This catalyzed Dr Hamad into thinking that her experience was not unique but part of a more universal narrative with accurate medical advice not always provided, in part, because advice was based on research that did not include women of color. <br /><br />Dr Hamad then went on to explain that ‘Intersectionality’ is a concept that was originally coined by law professor Kimberle Crenshaw in 1989 and provides a framework for understanding how different aspects of a person’s identify (e.g., race, gender, sexuality, class) overlap and interact with each other to shape their experiences of oppression and/or privilege. One of the key points that Nada emphasized was the need to move beyond our simplistic ideas around identity and oppression. She explained that while we often think of identity in terms of single, discrete categories (such as race or gender), the reality is much more complex. For example, we do not simply have a race problem here, or a gender problem there because a person may identify as both black and queer, and their experiences of oppression and privilege will be shaped by the intersection of these two aspects of their identity. In this sense, intersectionality highlights the ways in which different forms of oppression and privilege are interconnected and interdependent.<br /><br />To help illustrate this, Dr Hamad introduced the Wheel of Power as a visual representation of the different forms of power and privilege that exist in society (Figure 1). The wheel is divided into different sections, each of which represents a different form of power, such as wealth, race, gender, and sexuality. To help navigate this schematic through one’s “intersectionality glasses”, the more characteristics you have on the outside, the more compounded your oppressive experiences are. One of the key insights of the Wheel of Power is that different forms of power are interconnected and reinforce one another. For example, someone who is wealthy is likely to have more access to education, healthcare, and other resources that can contribute to their overall well-being. These various forms of power create a self-reinforcing system which will benefit some groups at the expense of others.<br /><br /><br /></span><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh1WDD5g7bn5c2ISD0fwtWwrsDDy6svBHL24Ec9Y2WNLkO_qMExw5VLdhM3zEerqrmDZEBOSfG0-fxEkvpEdKZVz-KIjt_vFtiYNhRS-2hRvePY17jLoGsghe6YTvv_g8r9yTsKKsEiUXOPSCV6UCJcuiWf5ZgsHTCEHHKA82DI9tkI5E6taY9TMK8cvA/s234/wheel%20of%20power.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="234" data-original-width="234" height="400" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh1WDD5g7bn5c2ISD0fwtWwrsDDy6svBHL24Ec9Y2WNLkO_qMExw5VLdhM3zEerqrmDZEBOSfG0-fxEkvpEdKZVz-KIjt_vFtiYNhRS-2hRvePY17jLoGsghe6YTvv_g8r9yTsKKsEiUXOPSCV6UCJcuiWf5ZgsHTCEHHKA82DI9tkI5E6taY9TMK8cvA/w400-h400/wheel%20of%20power.jpg" width="400" /></a></div><i style="font-family: arial;">Figure 1 The Wheel of Power</i><br /><div><span style="font-family: arial;"><br />Using the Wheel of Power can help raise your awareness of your own opportunity and oppression while understanding the needs of others. For example, you may not know what it's like to live in a place where the language you speak is not widely used, or to be poor, or to be uneducated, or to or to be in a wheelchair, but you can understand how those experiences are different. Conversely, you may not have considered that body size or not owning a home can lead to marginalization, especially when compounded with other factors.<br /><br />How does this help us with our research? First, it is important to understand that diversity in science refers to both the diversity of scientists themselves, as well as the diversity of the subjects that are studied. Dr Hamad emphasized that intersectionality is not just a theoretical concept, but a practical tool for creating change. By centring the experiences of those who are most marginalized and recognizing the complex interplay of different forms of oppression, we can create more inclusive and equitable systems and policies. Dr Hamad further explained that one of the actions we can all take when reading papers and analysing clinical datasets, is to ask several questions such as: (i) Whose stories are we missing in our research? (ii) Is the research serving the needs of the community? (iii) What implicit biases are reflected in my research material that will reinforce exclusion of marginalized people? For example, when it comes to AML in black patients – Dr Hamad showed that they are underrepresented in clinical trials, have poorer outcomes, and have less genomic information. Indeed, in black patients with AML, the NPM1, ASXL1 or TP53 status does not have the same prognostic relevance and inevitably leads to incorrect treatments because much of the molecular risk stratification used clinically is based on white patients.<br /><br />What now? All people, regardless of their race, gender, sexuality, or other characteristics, have the right to participate in science, and to have their voices and perspectives heard. Excluding certain groups from science, whether intentionally or unintentionally, can perpetuate existing inequalities and injustices. But inclusion, equity and accessibility are not end-points to be achieved and moved on from, rather they are a continuous process that everyone, even experts, can continue to learn about and work towards. Nada suggested each of us can check out your own implicit biases here:<br /><br /><a href="https://implicit.harvard.edu/implicit/">https://implicit.harvard.edu/implicit/</a><br /><br /><a href="https://idiinventory.com">https://idiinventory.com<br /></a><br />Finally, Nada noted it takes a lot of energy to continuously think about intersectionality and build inclusive, and diverse research environments. However, we can all have a positive impact on the world we live in and be part of the change we want to see. Nada concluded with a simple but important message: if you see bias, kindly call it out, but call it out kindly. <br /><br />To view the full recording of the webinar, please <a href="https://www.iseh.org/general/custom.asp?page=isehwebinars" target="_blank">visit the ISEH website</a>.<br /><br />1. Science benefits from diversity. <i>Nature</i> vol. 558 5 (2018).<br /><br />2. Powell, K. These labs are remarkably diverse - here’s why they’re winning at science. <i>Nature</i> <b>558</b>, 19–22 (2018).<br /></span></div><div><span style="font-family: arial;"><br /></span></div><span style="font-family: arial;"><br /><br /><i>Blog post contributed by members of the ISEH Junior Faculty Committee:<br />Charles de Bock - @charles_debock<br />Kellie Machlus - @theclotthickens<br />Vanessa Scanlon - @VanessaScanlon</i></span><div><br /></div><span><a name='more'></a></span><div><br /></div><div><i style="background-color: white; color: #757575; font-family: arial; font-size: 15px;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-38643679692995224972023-02-09T11:26:00.005-06:002023-02-09T11:26:43.252-06:00A New Working Model: Lessons from the COVID-19 Pandemic<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgE2HWpkEFnYPkf5cbVRU7__wO3Q8LYxBEuMv37DpPZzuPAMRAFZ4Ca7KMyFt1fln4pePeE4sohmklrsEfeBWmPChQQaxFUB4JmwUOjr4pDcYbMPQVik5X6Q9lIHW2NB5YYiigxCaPGFeykGkgYk0BSfVSEc4JaGJvOprJmM2D-_twOrVxKPtLV0L83-Q/s1600/Reducing%20Animal%20Use%20in%20Hematopoiesis%20Research%20-%20Recent%20Advances%20and%20Future%20Challenges%20(3).png" imageanchor="1" style="margin-left: 1em; margin-right: 1em; text-align: center;"><img border="0" data-original-height="900" data-original-width="1600" height="360" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgE2HWpkEFnYPkf5cbVRU7__wO3Q8LYxBEuMv37DpPZzuPAMRAFZ4Ca7KMyFt1fln4pePeE4sohmklrsEfeBWmPChQQaxFUB4JmwUOjr4pDcYbMPQVik5X6Q9lIHW2NB5YYiigxCaPGFeykGkgYk0BSfVSEc4JaGJvOprJmM2D-_twOrVxKPtLV0L83-Q/w640-h360/Reducing%20Animal%20Use%20in%20Hematopoiesis%20Research%20-%20Recent%20Advances%20and%20Future%20Challenges%20(3).png" width="640" /></a><br /><br /><b> 1. Introduction<br /></b><br />Since the report of a serial of mysterious pneumonia cases in Wuhan, China at the end of 2019, the COVID-19 pandemic has already lasted for over 3 years. A lot of things have changed in our daily and professional life, most were unimaginable before this bizarre time. These include border closures, nation-wide lockdowns and people rushing to supermarkets for toilet papers. But not all changes are bad, and the future will likely embrace some of these positive changes such as flexible learning and working models and accelerated research on mRNA vaccine development and other scientific areas. In this blog post, the members of the ISEH New Investigator Committee will discuss our view on how the pandemic affect our working models as hematologists.<br /><br /><b>2. The old normal<br /></b><br />The old norm refers to the way things were done before the COVID-19 Pandemic. This would typically involve work and socialize in-person, travel freely and attend large gatherings. <br /><br />In academia, the old norm would be in-person classes, face-to-face meetings with students and colleagues, and on-campus events and activities. Researchers would typically conduct experiments and studies in laboratories or other specialized research facilities, and would often collaborate with other researchers in person, attending conferences and workshops to share their findings and discuss their work with others in their field. There was also a strong emphasis on publishing research findings in academic journals and presenting at conferences in order to share knowledge and advance the field.<br /><br /><b>3. The new normal<br /></b><br /><i><u>Fully remote positions; Internationally relocated labs<br /></u></i><br />Since the outbreak of COVID-19, there have been many changes to the way people live and work. The "new norm" for many people has involved staying at home, practicing social distancing, wearing masks in public, and working remotely. These changes have had a major impact on people's daily lives and routines, and it's likely that some of these changes will continue even after the pandemic is over.<br /><br />Many businesses have had to adapt to these changes by implementing new policies and technologies to support remote work and online communication. Some have established a hybrid working mode that employees have more flexibility to get work done when, how, and where they're most productive. The others may had made positions to be fully remote or international relocated. <br /><br />In academia, the shift to remote learning and the cancellation of in-person events have certainly been necessary in order to keep students, faculty, and staff safe. But they have also had a significant impact on the way that education is delivered, and research is conducted. Many researchers have had to adapt to a more digital way of working, using online tools and platforms to collaborate with colleagues, conduct experiments and surveys. This had also led to a shift towards open access publishing and the use of digital platforms to share their work with a wider audience. <br /><br />One of the biggest challenges that researchers have faced during the COVID-19 pandemic is the impact on their work-life balance. Many have reported increased stress and digital fatigue as a result of the need to work remotely and adapt to new technologies and methods. This has had a negative impact on their autonomy, competence, and relatedness, and has raised concerns about the long-term effects of the pandemic on academic work and the research sector as a whole.<br /><br />Despite these challenges, the shift to remote learning and the cancellation of in-person events has also offered some advantages. Many researchers have found that the emergency remote working has offered them greater flexibility, allowing them to work from anywhere and at any time. This has also helped to develop their digital skills, enabling them to use new tools and platforms to conduct research and share their findings. The precedent set by the COVID-19 pandemic could also be advantageous in the long term, if it leads to a more flexible and adaptable academic workforce.<br /><br /><b>4. Tips to improve productivity when WFH<br /></b><br /><u><i>How to handle 8 hours of Zoom meetings<br />How to remain connected with your colleagues (Slack, virtual happy hours)<br /></i></u><br />Some of the challenges of this “new normal” have had a major impact in researcher’s productivity. To try to adapt to this new way of doing research, we summarize below some tips to try to stay productive whilst working from home. <br /><br /><ul style="text-align: left;"><li>Arrange a <b>designated working space</b>. This is crucial to switch your mindset to “working mode”, especially in the morning or after lunch. Keep it tied and organized in the same way you would have in the office, and try to (space allowing) make this space physically separated from your bedroom.</li><li><b>Take breaks</b>, especially in between Zoom meetings. Zoom is exhausting and looking at a screen for many hours on a row gets almost unbearable after a few days. Plan your meetings to be 50 minutes instead of 1 hour, so that you get 10 minutes of fresh air before continuing with more Zoom calls.</li><li><b>Remain connected</b>. There’s many tools to stay in touch with colleagues in a remote workplace. Slack is a great platform to interact with colleagues in a more dynamic and less formal way than sending emails. Also, some labs or even departments organize virtual happy hours. Most of the main hematology conferences, including ISEH Annual Meeting and ASH also include “virtual” interaction platforms and networking opportunities, so make the most out of those!</li></ul><br /><b>5. The future model <br /></b><br /><u><i>Hybrid working style<br />Personal preferences<br /></i></u><br />In the present and near future, many researchers are switching to a “hybrid” working style in which they spend some days at the office and work from home the rest of the week. The percentage of time varies from researcher to researcher and the experimental requirements of every project, and of course, personal preferences. <br /><br />Fully remote and internationally-relocated positions also exist for computational biologists and senior scientists or management staff (there’s even remote lab managers!). This is a great way to find a better work-life balance when growing a family, for caregivers or people that wouldn’t otherwise join a lab in a different country. Despite the challenges associated with this model, especially from a human resources perspective, fully remote positions are starting to become more common in research institutes and are actively being embraced by many of our colleagues.<br /><br />Indeed, the future model is definitely more flexible than our typical 8-hour working day in the office, and will hopefully offer better opportunities of professional growth for all stages of a hematology research career.<br /><br /><b>6. Concluding remarks<br /></b><br />The beginning of 2023 marks a new phase of this unprecedented crisis. The majority of countries have learnt to live with COVID-19 and complete lockdown and travel ban are no longer the way to go. Instead, flexible policies have been integrated into many aspects of our personal and professional life. With the Chinese government finally abandons its COVID-zero policy and allows international travel, ISEH is looking forward to a new year of events such as our annual meeting in New York to engage with members of the hematology research from the globe. <br /><br /><br /><br /><b>References<br /></b><br />Fiona McGaughey, Richard Watermeyer, Kalpana Shankar, Venkata Ratnadeep Suri, Cathryn Knight, Tom Crick, Joanne Hardman, Dean Phelan & Roger Chung (2021) ‘This can’t be the new norm’: academics’ perspectives on the COVID-19 crisis for the Australian university sector, Higher Education Research & Development, DOI: <u>10.1080/07294360.2021.1973384</u><br /><br />Kalpana Shankar, Dean Phelan, Venkata Ratnadeep Suri, Richard Watermeyer, Cathryn Knight & Tom Crick (2021) ‘The COVID-19 crisis is not the core problem’: experiences, challenges, and concerns of Irish academia during the pandemic, Irish Educational Studies, 40:2, 169-175, DOI: <u>10.1080/03323315.2021.1932550<br /></u><br />Richard Watermeyer, Kalpana Shankar, Tom Crick, Cathryn Knight, Fiona McGaughey, Joanna Hardman, Venkata Ratnadeep Suri, Roger Chung & Dean Phelan (2021) ‘Pandemia’: a reckoning of UK universities’ corporate response to COVID-19 and its academic fallout, British Journal of Sociology of Education, 42:5-6, 651-666, DOI: <u>10.1080/01425692.2021.1937058</u><div><u><br /></u></div><div><u><br /></u></div><div><div><span style="color: #757575; font-family: arial;"><span style="background-color: white; font-size: 15px;"><i>Blog post contributed by members of the ISEH New Investigators Committee:</i></span></span></div><div><span style="color: #757575; font-family: arial;"><span style="background-color: white; font-size: 15px;"><i>Alba Rodriguez Meira, PhD - </i></span></span><span style="color: #757575; font-family: arial;"><span style="font-size: 15px;"><i>@AlbaRMeira</i></span></span></div><div><span style="color: #757575; font-family: arial;"><span style="background-color: white; font-size: 15px;"><i>Dawn Lin, PhD - </i></span></span><span style="color: #757575; font-family: arial;"><span style="font-size: 15px;"><i>@DawnSLin</i></span></span></div><div><span style="color: #757575; font-family: arial;"><span style="background-color: white; font-size: 15px;"><i>Jingjing Li, PhD - </i></span></span><span style="color: #757575; font-family: arial;"><span style="font-size: 15px;"><i>@JaneLi_BME</i></span></span></div><div><br /></div><div><span style="color: #757575; font-family: arial;"><span style="background-color: white; font-size: 15px;"><i><br /></i></span></span></div><div><i style="background-color: white; color: #757575; font-family: arial; font-size: 15px;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></div></div><div class="separator" style="clear: both; text-align: center;"><br /></div><br />ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-76576776721759473632022-12-02T07:00:00.000-06:002022-12-02T07:00:00.172-06:00Lab Spotlight: Tikhonova Lab<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgjotq7llKCw3AeKXKtYbwr94w5xvhN_NxJ8ggfqOh4oIBeHgcuXefcwuJpw4ajlQ2LCH7NSh4Rx7_gvc9C-H7Tgo1JrY06TKYhuG-Qj9ySGpXBLQrTWczRVJy9VkDf9rGFyWusZoYqV7CK9XF-lPLvDorB_3-PSi6b_rQojxCJOlVJbvPg1dZRArdxYw/s4032/Tikhonova%20Lab.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="3024" data-original-width="4032" height="480" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgjotq7llKCw3AeKXKtYbwr94w5xvhN_NxJ8ggfqOh4oIBeHgcuXefcwuJpw4ajlQ2LCH7NSh4Rx7_gvc9C-H7Tgo1JrY06TKYhuG-Qj9ySGpXBLQrTWczRVJy9VkDf9rGFyWusZoYqV7CK9XF-lPLvDorB_3-PSi6b_rQojxCJOlVJbvPg1dZRArdxYw/w640-h480/Tikhonova%20Lab.jpg" width="640" /></a></div><span style="font-family: arial;"><br /><br />Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Tikhonova Lab which is based out of the University of Toronto and Princess Margaret Cancer Centre in Canada (<a href="https://tikhonovalab.com">https://tikhonovalab.com</a>). <br /><br /><b>How long have you had your lab and who is currently in your group?<br /></b><i><br />We started in August 2020 and have been growing ever since. Our diverse and multidisciplinary team has two postdoctoral fellows, two Ph.D. students, an animal technician, part-time computational scientific associate, and a lab manager.</i><br /><br /><b>What made you interested in pursuing a career as an academic researcher?<br /></b><br /><i>I always valued academic research as it affords me the freedom to pursue my own ideas. You are only limited by your imagination and, at times, technology.</i><br /><br /><b>What is the major research theme of your lab and how did you choose your lab’s focal point?<br /></b><br /><i>The focus of our group is to understand how microenvironmental factors regulate the process of blood and immune cell production or hematopoiesis in different contexts. For instance, how does this process change with infection or in cancer? I did my graduate training in Immunology, where it is all about connecting the dots and gaining clarity. So, working on microenvironment – a mix of immune, endothelial, and stromal ingredients – is a natural choice for me.</i><br /><br /><b>What is the most exciting story developing in your lab right now?<br /></b><br /><i>Honestly, I think all the projects we are pursuing are exciting and impactful. The overarching theme in our lab is microenvironment in the context of stress such as inflammation, leukemogenesis, or regeneration. One story that has been rapidly yielding exciting results is focused on delineating the immune microenvironment in high-risk leukemias. We hope to understand exactly how certain immune actors promote or impair cancer and ultimately redirect the immune responses against these devastating malignancies.</i><br /><br /><b>What’s the biggest accomplishment your lab has had recently?<br /></b><br /><i>I would say our biggest accomplishment to date is setting a solid foundation. Every trainee in the lab has a well-defined project, all the key infrastructure is set up, and collaborations are defined. Everyone knows where they want to be and what they need to do to get there. I believe that with a foundation like that, discoveries are quick to follow.</i><br /><br /><b>What is the key to running a successful research group?<br /></b><i><br />Team culture is critical to the success of an initiative. While people in the lab come from all over the world and have different backgrounds, we are united by our love for scientific discovery. We think deeply, we prep, we follow-up, we check and triple check. We leave no stone unturned. We share a vision and strive for excellence.</i><br /><br /><b>What was the most exciting part about starting your new lab? What was the most challenging?<br /></b><br /><i>Doing out of the box experiments and getting unexpected insights into biology. Witnessing my graduate students discussing where to do their postdocs. Getting consistent results. Seeing a new hot paper posted in Slack-chat bright and early Thursday morning. I love it all. I think that clearly defining lab standards and enforcing accountability can be challenging at times, but that is how we move ahead.</i><br /><br /><b>What advice do you have for new scientists who are thinking about starting their own labs?<br /></b><br /><i>Focus on the big picture. No. Bring together a stellar team of motivated and creative individuals who you can learn from and grow with. Then, focus on the big picture.</i><br /><br /><b>Does your lab have any fun traditions? How do you celebrate accomplishments?<br /></b><br /><i>Toronto is a beautiful city with great restaurants and lovely parks. So we eat out and organize picnics. During the pandemic it was hard to feel upbeat, so now we take every opportunity to celebrate. We are definitely celebrating this blog post with rosé!</i></span><div><span style="font-family: arial;"><br /></span><div><span style="font-family: arial;"><br /></span></div><div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i>Blog post contributed by: <b>Alyssa Cull</b>, ISEH Publications Committee</i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i style="color: #757575;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></span></div></div></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-35661384115164559442022-11-10T12:39:00.006-06:002022-11-10T12:39:35.349-06:00ISEH 2022 Annual Scientific Meeting – Highlights from the New Investigators Committee<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj3Ys5nlF9PBE0f0TeXmW0bnofi1v7fTGszvmAe0Ii7DyqYN13owSIAQL_8xRyC9k8dF2Y8qigX7ODB8c3Pv1KpcUqaq8cmcWMTbP3E0Gj3HfiV517o2vjKVcTcqUMJJOCQ0ikfQTHvx0jwSmsGCsFO5k2Q0qIIuNcLUEHiE9XnSDJfSi-6tPre5CBHwA/s1024/ISEH_758735-21_AnnualMeeting2022_WB-1024x512%20Twitter.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em; text-align: center;"><img border="0" data-original-height="512" data-original-width="1024" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj3Ys5nlF9PBE0f0TeXmW0bnofi1v7fTGszvmAe0Ii7DyqYN13owSIAQL_8xRyC9k8dF2Y8qigX7ODB8c3Pv1KpcUqaq8cmcWMTbP3E0Gj3HfiV517o2vjKVcTcqUMJJOCQ0ikfQTHvx0jwSmsGCsFO5k2Q0qIIuNcLUEHiE9XnSDJfSi-6tPre5CBHwA/w640-h320/ISEH_758735-21_AnnualMeeting2022_WB-1024x512%20Twitter.jpg" width="640" /></a><br /><span style="font-family: arial;"><br /></span><div><span style="font-family: arial;">For four days in September, more than 500 ISEH members travelled from 25 countries around the world to beautiful Edinburgh in Scotland for the ISEH Annual Scientific Meeting. Attendees were treated to an amazing program of speakers, and given the opportunity to network and present their work to the community in lively social events and poster sessions.<br /><br />The meeting also included events targeting the students and postdocs that make up the ISEH new investigator community. In this blog post, members of the ISEH New Investigator Committee summarize some of their meeting highlights:<br /><br /><span style="color: #32a1d9;"><b>New Investigator Pre-Meeting Workshop</b><br /></span><br />The ISEH pre-meeting workshop allowed trainees to present their research and network within the community. We first heard five great talks from trainees, then all of the trainees presented posters. ISEH faculty were invited to the event to judge both the oral and poster presentations, so every trainee got to talk to at least three faculty about their work. The afternoon also included an interactive Q&A session focused on Peer-Review Publishing. The trainees got the opportunity to grill three journal editors (Emmanuelle Passegue from JEM, Louise Purton from ExpHem, and David Kent from HemaSphere) on the peer-review publication process and received advice from them on how to succeed in publishing. We would like to extend a special thank you to these editors to joining the session, all the poster judges for joining the event, and Marella de Bruijn, Anna Bigas, and Grant Challen for running the workshop. Congratulations to all workshop awardees:</span></div><div><span style="font-family: arial;"><br /></span></div><div><span style="font-family: arial;">Best Oral Presentations</span></div><div><span style="font-family: arial;">- Esther Rodriguez Correa (PhD student, HI-STEM, Germany) </span></div><div><span style="font-family: arial;">- Gavin Tjin (Postdoc, St Vincent's Institute, Australia)</span></div><div><span style="font-family: arial;"><br /></span></div><div><span style="font-family: arial;">Best Poster Presentations</span></div><div><span style="font-family: arial;">- Chris Nevitt (Postdoc, St Jude Children's Research Hospital, USA)</span></div><div><span style="font-family: arial;">- Yurim Park (PhD Student, University of Oxford, UK)<br /><br /><br /><span style="color: #32a1d9;"><b>New Investigator Technology Session</b><br /></span><br />The technology session highlighted the expertise of students and postdocs that developed and utilized new experimental tools. This year, the focus of the session was on the latest advances in ex vivo HSC expansion systems. Kyomi Igarashi (PhD student, Stanford, USA) discussed the polyvinyl alcohol (PVA) system, Dr Shubhankar Sood (Postdoc, HI-STEM, Germany) described an HSC co-culture system with mesenchymal stromal cells (MSCs) and Dr Juan Rubio-Lara (Postdoc, York, UK) introduced STEMBOND hydrogels for HSC expansion. They provided other new investigators tips and tricks to design and execute successful experiments using these new techniques.<br /><br /><br /><b><span style="color: #32a1d9;">Meet the Expert Mixer</span></b></span></div><div><span style="font-family: arial;"><b><br /></b>During this highly interactive networking event, students and postdocs enjoyed a relaxing evening with food and drinks while mingling with some of the most recognizable hematology researchers from around the globe. Each participant had the chance to meet 3 of our experts to ask them about their science, career trajectory and how to overcome some of the challenges associated with an academic career path. A huge thank you to our experts this year including Drs Louise Purton (SVI, Australia), David Kent (York, UK), Christina Halsey (Glasgow, UK), Simon Haas (MDC Berlin, Germany), Julie Lessard (Montréal, Canada), Bertie Göttgens (Cambridge, UK), Mick Milsom (Hi-STEM, Germany), Mihaela Crisan, (Edinburgh, UK), John Crispino (St. Jude, USA), Jennifer Trowbridge (Jackson, USA).<br /><br /><br /><b><span style="color: #32a1d9;">New Investigator Career Session</span></b><br /><br />This session allowed ISEH trainees to learn more about various scientific career paths, and to have an opportunity to ask questions in a more relaxed setting. We heard about the scientific journeys of four incredible scientists who also gave us valuable advice on how to make the most out of our training years. This session was led by Drs Nina Cabezas-Wallscheid (Freiburg, Germany), Robert Signer (Los Angeles, USA), Luca Cassetta (Edinburgh, UK) and Francesco Severi (EHA).<br /><br /><b><span style="color: #32a1d9;">The Science</span></b></span></div><div><span style="font-family: arial;"><b><br /></b>The scientific sessions at ISEH 2022 covered a wide range of topics from developmental biology to new technological advances in ex vivo culturing systems, molecular characterization of healthy hematopoietic development and how these pathways are disrupted in disease.<br /><br />Dr. Allison Petit (Perth, Australia) gave a brilliant talk about how macrophage fragmentation confounds ex vivo hematopoietic analysis. She showed us how macrophages seemed to disappear during the preparation of bone marrow single-cell suspensions. An audible intake of breath spread across the auditorium as she clearly showed large fragments of the disrupted macrophage remnants attached to other cell types of interest, and how they can confound results derived from techniques like scRNA-seq. It may become a new standard to add a macrophage exclusion marker in our sorting strategies to minimize contamination. This talk was a real eye opener to all of us.<br /><br />Dr. Simon Haas (BHI and HI-STEM, Germany), a past member of the New Investigator Committee, presented a captivating story on the antigen presenting properties of hematopoietic stem cells (HSCs). His findings, derived from elegant analyses of single-cell transcriptomic datasets, showed that HSCs present antigens to CD4+ T cells to eliminate transformed cells that might cause leukemia development. This unexpected mechanism to preserve stem cell integrity, and the functional connection between HSCs and the immune system made it an incredibly exciting talk.<br /><br /><br /><b><span style="color: #32a1d9;">Scottish Ceilidh (Aye!)</span></b><br /><br />A traditional Scottish Ceilidh was the best way to conclude ISEH2022. We were hosted by the National Museum of Scotland (the home of Dolly the sheep), which is just a few minutes away from the historic Edinburgh City Centre. This incredible venue was the perfect place to unwind and have fun after a few days of non-stop science. This was a memorable way to end our first in-person conference since 2019!<br /><br /><br /><b><span style="color: #32a1d9;">Some other experiences of the 2022 ISEH Annual Scientific Meeting from New Investigators:</span><br /></b><br /><i>“The first time I had the opportunity to attend a conference during my PhD was this year in ISEH Edinburgh. Personally, I was extremely excited about the conference and the idea of presenting my work to other researchers in the field. The experience definitely exceeded my expectations. <br /><br />ISEH has been a learning experience, where I got valuable feedback and where I had constant exposure to the current research in the field, state-of-the-art technologies as well as opinions, advices and perspectives coming from experienced researchers.<br /><br />One of the most enriching aspects was the social interaction with other trainees. I enjoyed sharing our scientific projects and personal experiences, but what I appreciated the most was the excitement and passion that everyone had for their research topics. ISEH had such an amazing scientific vibe, where you clearly appreciate the enthusiasm for doing science, and for a young researcher that is really encouraging.”</i><br /><br />- Esther Rodriguez Correa, PhD student, HI-STEM & DKFZ, Germany<br /><br /><br /><i>"This was my first in-person ISEH, after the virtual edition of 2021. During my Ph.D., I always thought it would be great to attend, the reputation of this meeting is just incredible. And totally deserved to be fair, I was blown away by the excellent quality of the science presented in Edinburgh! But the most rewarding experience was finally meeting all those brilliant scientists from around the world. Regarding the more senior figures, I was a bit intimidated, essentially because of their excellent academic reputation; ISEH made a wonderful job of creating a relaxed environment, and all the senior scientists were approachable and relatable. And about the more junior scientists, I had more than my fair share of occasions to share a drink and laugh with them! I am quite proud to be part of a community that promotes a friendly and inclusive environment!<br /><br />Finally, I just want to acknowledge two of the awardees for 2022: Dr. David Kent and Prof Louise Purton delivered some poignant and well-timed talks about inclusivity, the gender gap, representation, and other matters that are close to my heart. We should strive for those causes and put them at the center of our professional activities"</i><br /><br />- Alessandro Donada, Postdoctoral Researcher, Institute Curie, Paris, France</span><div class="separator" style="clear: both; text-align: center;"><span style="font-family: arial;"><br /></span></div><br /></div><div><span style="color: #757575; font-family: arial;"><span style="background-color: white; font-size: 15px;"><i>Blog post contributed by members of the ISEH New Investigators Committee.</i></span></span></div><div><span style="color: #757575; font-family: arial;"><span style="background-color: white; font-size: 15px;"><i><br /></i></span></span></div><div><i style="background-color: white; color: #757575; font-family: arial; font-size: 15px;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-16316727850429688672022-10-06T08:54:00.002-05:002022-10-06T08:55:57.115-05:00 Lab Spotlight: Sturgeon Lab<p><span style="font-family: arial;"><span style="line-height: 107%;">Each month, Simply Blood spotlights a
lab focused on the research of basic hematology, immunology, stem cell
research, cell and gene therapy, and other related aspects. Get to know these
different labs around the world! This month, we are featuring the Sturgeon Lab
(</span><a href="http://www.sturgeonlab.com/"><span style="line-height: 107%;">www.sturgeonlab.com</span></a><span style="line-height: 107%;">) </span>at the Icahn School of Medicine at Mount Sinai located in New York City, New York, USA.</span></p><p></p><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhTncK9DdKtb0wEG6u5VXnqag3y9dNsbgL66aFM17EUXsC9sXiTInqrTxYSOJ2Zl-KZd3BW6QkEjef_sRTs89DYWVz8boFlrpXFsXh53329EJ_Gl7qzmTbA-RfJeMkiV0zQz1-ffKOz_r7UdwB_sbqIRvsCAA1EXK3bO9W0FWp7_OXiheMwSFeOetFqtg/s1232/Sturgeon%20Lab.jpg" style="margin-left: auto; margin-right: auto;"><span style="color: black;"><img border="0" data-original-height="924" data-original-width="1232" height="300" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhTncK9DdKtb0wEG6u5VXnqag3y9dNsbgL66aFM17EUXsC9sXiTInqrTxYSOJ2Zl-KZd3BW6QkEjef_sRTs89DYWVz8boFlrpXFsXh53329EJ_Gl7qzmTbA-RfJeMkiV0zQz1-ffKOz_r7UdwB_sbqIRvsCAA1EXK3bO9W0FWp7_OXiheMwSFeOetFqtg/w400-h300/Sturgeon%20Lab.jpg" width="400" /></span></a></td></tr><tr><td class="tr-caption" style="text-align: center;"><span style="font-family: arial; font-size: x-small;">Sturgeon Lab at Icahn School of Medicine at Mount Sinai, Twitter: @Dr_Sturgeon</span></td></tr></tbody></table><span style="font-family: arial; font-size: 11pt; line-height: 107%;"><br /></span><p></p>
<p style="margin-bottom: 0in; margin-left: 0in; margin-right: 0in; margin-top: 12.0pt; margin: 12pt 0in 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><span style="font-family: arial;">How long have you had your lab? <o:p></o:p></span></span></b></p>
<p style="margin-bottom: 0in; margin-left: .5in; margin-right: 0in; margin-top: 12.0pt; margin: 12pt 0in 0in 0.5in; vertical-align: baseline;"><i><span style="font-size: 11pt;"><span style="font-family: arial;">I first opened my lab at Washington University, in March of
2014.<span style="mso-spacerun: yes;"> </span>We then moved to Mount Sinai in
New York in August of 2020.<o:p></o:p></span></span></i></p>
<p style="margin-bottom: 0in; margin-left: 0in; margin-right: 0in; margin-top: 12.0pt; margin: 12pt 0in 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><span style="font-family: arial;">What was your biggest transition from a post-doc to a group
leader/lab PI?<o:p></o:p></span></span></b></p>
<p style="margin-bottom: 0in; margin-left: .5in; margin-right: 0in; margin-top: 12.0pt; margin: 12pt 0in 0in 0.5in; vertical-align: baseline;"><span style="font-size: 11pt;"><span style="font-family: arial;">Or what do you miss most from your post-doc time?<i> I
remember being so overwhelmed and star-struck just seeing, for the first time,
the space that was going to be my lab.<span style="mso-spacerun: yes;">
</span>So much so, that I forgot to ask key questions about how things like
renovations could be handled, HVAC and electrical limitations on equipment,
space/growth limitations, etc.<span style="mso-spacerun: yes;"> </span>All I
could think was “I *actually* made it!”. I’ll never forget that feeling. As a
postdoc, you’re often hyper-focused on the experiment in front of you, the data
you have, and the next experiment to do. Once you’re a PI, not only do you have
to have a “big picture” point of view on a project, but on multiple projects,
*and*, non-science things like budgets, administration, grants, managing
trainees, and committees.<span style="mso-spacerun: yes;"> </span>Sometimes I
miss the days of only worrying if my experiments work!</i><o:p></o:p></span></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></b></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><span style="font-family: arial;">What was the most exciting part about
starting your new lab? <o:p></o:p></span></span></b></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: 0in; margin-left: .5in; margin-right: 0in; margin-top: 0in; margin: 0in 0in 0in 0.5in; vertical-align: baseline;"><i><span style="font-size: 11pt;"><span style="font-family: arial;">Sitting down with a pen and paper, sketching out your lab space, and
figuring out where you’ll put an incubator, a biosafety cabinet, centrifuges,
freezers… it sounds so silly, but that was unbelievably exciting. And then once
it’s all there, you thaw cells for the first time, and they grow.<span style="mso-spacerun: yes;"> </span>It’s such a relief, even though it’s the most
basic thing you’ve been doing as a postdoc for years prior, now you’re doing it
with your own reagents, in your own lab – and it all starts to be clear, things
are going to be ok!<o:p></o:p></span></span></i></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><span style="font-family: arial;">What is the major research theme of
your lab and what is the most exciting project in your lab right now?<i> <o:p></o:p></i></span></span></b></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><i><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></i></p>
<p style="margin-bottom: 0in; margin-left: .5in; margin-right: 0in; margin-top: 0in; margin: 0in 0in 0in 0.5in; vertical-align: baseline;"><span style="font-family: arial;"><i><span style="font-size: 11pt;">We are focused on understanding vertebrate embryonic hematopoietic
development, and recapitulating those processes in human pluripotent stem cell
differentiation cultures.<span style="mso-spacerun: yes;"> </span>Our work has
really brought an emphasis to early differentiation stages – like really early,
during gastrulation-like stages of the cultures.<span style="mso-spacerun: yes;"> </span>By modulating the critical signal pathways
WNT, BMP, NODAL, or RA, we obtain quite distinctly different hematopoietic
progenitors. Right now, one project I’m really excited about is exploring the adoptive
immunotherapy potential of these different progenitors.<span style="mso-spacerun: yes;"> </span>Do embryonic progenitors have “untapped”
clinical potential, that we just haven’t realized because they aren’t found in
traditional donor sources?<span style="mso-spacerun: yes;"> </span>And if so,
could pluripotent stem cells be that source?<span style="mso-spacerun: yes;">
</span>For so long, we as a field have been obsessed (and rightly so) with
identifying a method to differentiate pluripotent stem cells into hematopoietic
stem cells.<span style="mso-spacerun: yes;"> </span>But what if an
HSC-independent progenitor, which we are often tossing aside in that quest,
actually has some clinical utility?<span style="mso-spacerun: yes;"> </span>I
think this is a really exciting question right now.</span></i><span style="font-size: 11pt;"><o:p></o:p></span></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><span style="font-family: arial;">How many members make up your lab?
Students/postdocs?<span style="mso-spacerun: yes;"> </span><o:p></o:p></span></span></b></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: 0in; margin-left: .5in; margin-right: 0in; margin-top: 0in; margin: 0in 0in 0in 0.5in; vertical-align: baseline;"><span style="font-family: arial;"><i><span style="font-size: 11pt;">We are a relatively small group right now, but are always looking to add
more.<span style="mso-spacerun: yes;"> </span>Right now my lab is comprised of 3
postdocs, 1 technician, 1 lab manager, and a summer student. </span></i><span style="font-size: 11pt;"><o:p></o:p></span></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><span style="font-family: arial;">How important was mentorship to you
during the early stages of your career and how do you mentor trainees?<o:p></o:p></span></span></b></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: 0in; margin-left: .5in; margin-right: 0in; margin-top: 0in; margin: 0in 0in 0in 0.5in; vertical-align: baseline;"><span style="font-family: arial;"><i><span style="font-size: 11pt;">It goes without saying that I would have never made it here without the
mentorship of my postdoc supervisor. But when I first started my lab, I didn’t
have a formal mentor structure. In retrospect, certainly it would have helped
me, but instead, I did my best to seek out colleagues who could provide me with
honest feedback on grants and lab management, which are the things postdocs
have the least experience with. I am forever indebted to those who helped me
along the way. Now, in my own lab, I first try to understand what my trainees’
career goal is – as a simple example, industry or academia. From there, I do my
best to try and formulate a project together that will make them competitive
for that position – and that can take on many forms. There really isn’t a magic
formula, each person responds to feedback in different ways. But we make a
point of meeting once a week to discuss anything ranging from data, project
planning, and career goals.</span></i><span style="font-size: 11pt;"><o:p></o:p></span></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></b></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><span style="font-family: arial;">What is your lab’s most recent
accomplishment? And how do members of your lab celebrate accomplishments? Or does
your lab have any fun traditions yet?<i> <o:p></o:p></i></span></span></b></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><i><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></i></p>
<p style="margin-bottom: 0in; margin-left: .5in; margin-right: 0in; margin-top: 0in; margin: 0in 0in 0in 0.5in; vertical-align: baseline;"><span style="font-family: arial;"><i><span style="font-size: 11pt;">We just had a series of papers published this year, in Development, Stem
Cell Research, and Nature Cell Biology.<span style="mso-spacerun: yes;">
</span>For each, we have a little tradition that I actually stole from my PhD
advisor - we pop a bottle of bubbly, and let the cork make a dent in the
ceiling.<span style="mso-spacerun: yes;"> </span>The first author of that paper
signs the ceiling next to the dent, and then we all enjoy that bottle (and
maybe some more).<span style="mso-spacerun: yes;"> </span>I keep the cork, and
put it in a big jar.<span style="mso-spacerun: yes;"> </span>My goal is that by
the end of my career, that jar will be overflowing with corks!</span></i><span style="font-size: 11pt;"><o:p></o:p></span></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><span style="font-family: arial;">What do you like most about your
current institution?<i> <o:p></o:p></i></span></span></b></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><i><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></i></p>
<p style="margin-bottom: 0in; margin-left: .5in; margin-right: 0in; margin-top: 0in; margin: 0in 0in 0in 0.5in; vertical-align: baseline;"><span style="font-family: arial;"><i><span style="font-size: 11pt;">I’m now part of the Black Family Stem Cell Institute here at Mount Sinai.
We are a diverse group of stem cell and developmental biologists – which I
absolutely love.<span style="mso-spacerun: yes;"> </span>In our faculty
meetings, there is such a wide variety of perspectives, which I think is going
to really benefit our research in the long term.<span style="mso-spacerun: yes;"> </span>Fly, fish, frog, mouse, and human iPSC, we
have it all here.</span></i><span style="font-size: 11pt;"><o:p></o:p></span></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><span style="font-family: arial;">What major advances do you predict in
your research field in the next 10 years? <o:p></o:p></span></span></b></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: 0in; margin-left: .5in; margin-right: 0in; margin-top: 0in; margin: 0in 0in 0in 0.5in; vertical-align: baseline;"><span style="font-family: arial;"><i><span style="font-size: 11pt;">Oh, there is so much to be excited about!<span style="mso-spacerun: yes;">
</span>I think we’re going to see an explosion in hPSC-derived
immunotherapies.<span style="mso-spacerun: yes;"> </span>NK cells are already in
the clinic. CAR-T cells, B cells engineered to produce specific antibodies,
probably even macrophages, are all going to be in use.<span style="mso-spacerun: yes;"> </span>But like I mentioned above, there’s been such
a long-standing focus on how HSCs develop, I do believe as a field we are
poised to see that finally come to fruition.<span style="mso-spacerun: yes;">
</span>And regardless of which group(s) do it first, it’s going to be a really
exciting time for all hPSC groups, because now we will have a platform to do
some really powerful developmental biology.</span></i><span style="font-size: 11pt;"><o:p></o:p></span></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><b><span style="font-size: 11pt;"><span style="font-family: arial;">What is the most beneficial aspect of
ISEH membership for you/your lab?<o:p></o:p></span></span></b></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p style="margin-bottom: 0in; margin-left: .5in; margin-right: 0in; margin-top: 0in; margin: 0in 0in 0in 0.5in; vertical-align: baseline;"><span style="font-family: arial;"><i><span style="font-size: 11pt;">ISEH is, without a doubt, my favorite society.<span style="mso-spacerun: yes;"> </span>The meetings have a perfect balance of adult
hematopoiesis, disease processes, embryonic development, and pluripotent stem
cell differentiation, so every session is really just a “can’t miss” event. I
always feel inspired on my way home after each meeting.</span></i><span style="font-size: 11pt;"><o:p></o:p></span></span></p>
<p style="margin-bottom: .0001pt; margin: 0in; vertical-align: baseline;"><span style="font-size: 11pt;"><o:p><span style="font-family: arial;"> </span></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size: 11pt; line-height: 107%;"><o:p><span style="font-family: arial;"> </span></o:p></span></b></p>
<p class="MsoNormal"><b><span style="color: #c00000; font-size: 11pt; line-height: 107%; mso-bidi-font-family: Arial; mso-fareast-font-family: "Times New Roman";"><span style="font-family: arial;">Christopher Sturgeon, Ph.D.<o:p></o:p></span></span></b></p>
<p class="MsoNormal"><span style="font-size: 11pt; line-height: 107%;"><span style="font-family: arial;">Icahn School of Medicine at Mount Sinai, New York City, New
York, USA<o:p></o:p></span></span></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0in; vertical-align: baseline;"><span style="font-family: arial;"><span style="font-size: 11pt;">Lab website: </span><a href="http://www.sturgeonlab.com/"><span style="font-size: 11pt;">www.sturgeonlab.com</span></a><span style="font-size: 11pt;"><span style="mso-spacerun: yes;"> </span></span></span></p>
<p class="MsoNormal" style="line-height: normal; margin-bottom: 0in; vertical-align: baseline;"><span style="font-family: arial;"><span style="font-size: 11pt;">Twitter: </span><a href="https://twitter.com/dr_sturgeon?lang=en"><span style="font-size: 11pt;">@Dr_Sturgeon</span></a></span><span style="color: black; font-size: 11pt; mso-bidi-font-family: Arial; mso-fareast-font-family: "Times New Roman";"><o:p></o:p></span></p><p class="MsoNormal" style="line-height: normal; margin-bottom: 0in; vertical-align: baseline;"><br /></p><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i>Blog post contributed by: <b>Charmaine Soco</b>, ISEH Publications Committee</i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i style="color: #757575;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></span></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-7053804534054921122022-09-08T08:42:00.003-05:002022-09-08T08:47:23.479-05:00Exploring Experimental Hematology: June 2021 (Volume 98)<p><b></b></p><div class="separator" style="clear: both; text-align: center;"><b><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiDIPJxhYrulcA-g87A12EtoRMtiurlLTEfGirUHiny9ub0UkiPk44iHvWKHiKVjfB2dw9fdYYH8iPGXWeWB6cIQoCGFcRUftc8rPSs3pX0qNDFx2oi5sTMKHgbW3FUXK2YrcaNDz5CP1rCopBYVTZGCTTa9k_mzINautYRwhqeOJtPWDykf5ZLHp2okQ/s1920/Exploring%20ExpHem.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="614" data-original-width="1920" height="205" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiDIPJxhYrulcA-g87A12EtoRMtiurlLTEfGirUHiny9ub0UkiPk44iHvWKHiKVjfB2dw9fdYYH8iPGXWeWB6cIQoCGFcRUftc8rPSs3pX0qNDFx2oi5sTMKHgbW3FUXK2YrcaNDz5CP1rCopBYVTZGCTTa9k_mzINautYRwhqeOJtPWDykf5ZLHp2okQ/w640-h205/Exploring%20ExpHem.png" width="640" /></a></b></div><b><span face="Arial, sans-serif" style="font-size: 14pt; text-align: center;"><br /></span></b><p></p><p><b><span face="Arial, sans-serif" style="font-size: 14pt; text-align: center;">DNA
methylation therapy joins forces in </span><i style="font-family: Arial, sans-serif; font-size: 14pt; text-align: center;">IDH2</i><span face="Arial, sans-serif" style="font-size: 14pt; text-align: center;">-mutant AML</span></b></p>
<p class="MsoNormal" style="text-align: justify;"><span face=""Arial",sans-serif">Isocitrate
dehydrogenases 1 and 2 (<i>IDH1</i>/2) are frequently mutated in Acute Myeloid Leukemia
(AML), with nearly 20% of patients carrying gain-of-function point mutations in
these genes </span><!--[if supportFields]><span style='font-family:"Arial",sans-serif'><span
style='mso-element:field-begin'></span><span
style='mso-spacerun:yes'> </span>ADDIN EN.CITE <span style='mso-element:field-begin'></span><span
style='mso-spacerun:yes'> </span>ADDIN EN.CITE.DATA <![if gte mso 9]><xml>
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</xml><![endif]><span style='mso-element:field-end'></span><span
style='mso-element:field-separator'></span></span><![endif]--><span face=""Arial",sans-serif">(Ley et
al., 2013)<!--[if gte mso 9]><xml>
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</xml><![endif]--></span><!--[if supportFields]><span style='font-family:"Arial",sans-serif'><span
style='mso-element:field-end'></span></span><![endif]--><span face=""Arial",sans-serif">. <i>IDH2</i> is a metabolic enzyme that catalyzes the conversion
of isocitrate to 2-oxoglutarate during the Krebs cycle. Patients carrying <i>IDH2</i>
gain-of-function mutations produce instead high levels of the oncometabolite 2-hydroxyglutarate
(2-HG), which inhibits oxoglutarate-dependent enzymes such as the TET family of
</span><span face=""Arial",sans-serif" style="background: white; color: #333333; mso-fareast-font-family: "Times New Roman";">methylcytosine dioxygenases,
responsible for active DNA demethylation </span><!--[if supportFields]><span
style='font-family:"Arial",sans-serif;mso-fareast-font-family:"Times New Roman";
color:#333333;background:white'><span style='mso-element:field-begin'></span><span
style='mso-spacerun:yes'> </span>ADDIN EN.CITE <span style='mso-element:field-begin'></span><span
style='mso-spacerun:yes'> </span>ADDIN EN.CITE.DATA <![if gte mso 9]><xml>
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</xml><![endif]><span style='mso-element:field-end'></span><span
style='mso-element:field-separator'></span></span><![endif]--><span face=""Arial",sans-serif" style="background: white; color: #333333; mso-fareast-font-family: "Times New Roman";">(Xu et al.,
2011)<!--[if gte mso 9]><xml>
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</xml><![endif]--></span><!--[if supportFields]><span style='font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman";color:#333333;background:white'><span
style='mso-element:field-end'></span></span><![endif]--><span face=""Arial",sans-serif" style="background: white; color: #333333; mso-fareast-font-family: "Times New Roman";">. As a consequence, <i>IDH2</i> mutations in AML patients </span><span face=""Arial",sans-serif">induce DNA hypermethylation and inhibit hematopoietic
differentiation </span><!--[if supportFields]><span style='font-family:"Arial",sans-serif'><span
style='mso-element:field-begin'></span><span
style='mso-spacerun:yes'> </span>ADDIN EN.CITE <span style='mso-element:field-begin'></span><span
style='mso-spacerun:yes'> </span>ADDIN EN.CITE.DATA <![if gte mso 9]><xml>
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</xml><![endif]><span style='mso-element:field-end'></span><span
style='mso-element:field-separator'></span></span><![endif]--><span face=""Arial",sans-serif">(Figueroa
et al., 2010)<!--[if gte mso 9]><xml>
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</xml><![endif]--></span><!--[if supportFields]><span style='font-family:"Arial",sans-serif'><span
style='mso-element:field-end'></span></span><![endif]--><span face=""Arial",sans-serif">.</span><span face=""Arial",sans-serif" style="mso-fareast-font-family: "Times New Roman";"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span face=""Arial",sans-serif">Azacytidine
(AZA) and enasidenib (ENA) are commonly used AML therapies which induce DNA
hypomethylation, albeit through different mechanisms. AZA is a nucleoside
analog that inhibits DNA methyltransferase enzymes (DNMTs) and ENA impairs <i>IDH2</i>
mutant catalytic activity </span><!--[if supportFields]><span style='font-family:
"Arial",sans-serif'><span style='mso-element:field-begin'></span><span
style='mso-spacerun:yes'> </span>ADDIN EN.CITE <span style='mso-element:field-begin'></span><span
style='mso-spacerun:yes'> </span>ADDIN EN.CITE.DATA <![if gte mso 9]><xml>
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</xml><![endif]><span style='mso-element:field-end'></span><span
style='mso-element:field-separator'></span></span><![endif]--><span face=""Arial",sans-serif">(Wang et
al., 2013)<!--[if gte mso 9]><xml>
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</xml><![endif]--></span><!--[if supportFields]><span style='font-family:"Arial",sans-serif'><span
style='mso-element:field-end'></span></span><![endif]--><span face=""Arial",sans-serif">. In a study recently published in <i>Experimental
Hematology</i> </span><!--[if supportFields]><span style='font-family:"Arial",sans-serif'><span
style='mso-element:field-begin'></span><span
style='mso-spacerun:yes'> </span>ADDIN EN.CITE <span style='mso-element:field-begin'></span><span
style='mso-spacerun:yes'> </span>ADDIN EN.CITE.DATA <![if gte mso 9]><xml>
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</xml><![endif]><span style='mso-element:field-end'></span><span
style='mso-element:field-separator'></span></span><![endif]--><span face=""Arial",sans-serif">(MacBeth
et al., 2021)<!--[if gte mso 9]><xml>
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</xml><![endif]--></span><!--[if supportFields]><span style='font-family:"Arial",sans-serif'><span
style='mso-element:field-end'></span></span><![endif]--><span face=""Arial",sans-serif">, Macbeth and colleagues hypothesized that combining both
drugs in <i>IDH2</i>-mutant leukemia will produce a synergistic effect to drive
hypomethylation and restore AML differentiation. <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span face=""Arial",sans-serif">To
test this hypothesis, the authors first performed combination or single agent
treatments on a leukemia cell line model overexpressing <i>IDH2</i> mutation (TF1
IDH2<sup>R140Q</sup> cells) and evaluated dose-dependent erythroid
differentiation via a hemoglobinization assay. Compared to single agent
treatments, combination treatment with high AZA and ENA doses showed the highest
rate of hemoglobinization. <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span face=""Arial",sans-serif">Their
findings were further strengthen using primary cells from AML patients carrying
<i>IDH2</i><sup>R172</sup> and <i>IDH2</i><sup>R140</sup> mutations. Differentiation
was assessed by flow cytometry using CD34<sup>+ </sup>(marking stem and
progenitor cells) and CD15<sup>+</sup> (marking granulomonocytic cells). Combination
treatment showed a reduction in CD34 and increased CD15 intensity, indicative
of myeloid differentiation, an effect that was not detected in <i>IDH2</i>-WT
AML samples.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span face=""Arial",sans-serif">Next,
they assessed genome-wide methylation profiles of AZA+ENA treatment on TF1 <i>IDH2</i><sup>R140Q</sup>
cells. 5hmC levels were evaluated using hydroxymethylated DNA
immunoprecipitation (hMeDIP) sequencing, showing an increase in 5hmC levels in
ENA treated and ENA+AZA treated cells, with no measurable effects in AZA-only treated
cells. Subsequently, 5mC was measured using EERBS (Enhanced Representation
Bisulfite Sequencing), showing a decrease in both single-agent AZA and
combination treatment, but no difference in single-agent ENA, concordant with
the known mechanism of action of this <i>IDH2</i> inhibitor. Overall, ENA+AZA combination
showed a greater degree of DNA hypomethylation than both single-agent treatments
alone. These findings support a model in
which restoration of TET activity cooperates with the inhibition of DNMTs to cooperatively
induce DNA hypomethylation in leukemic cells.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><span face=""Arial",sans-serif">Further
mechanistic studies would be needed to elucidate the precise molecular
mechanisms of AZA+ENA synergistic effect, such the identification of
methylation patterns at specific genomic regions and functional regulatory
elements responsible for the increased myeloid differentiation. DNA
hypomethylation agents are widely used in AML therapy, although only a modest
proportion of patients respond. Therefore, resolving the underlying mechanism
of action of DNA methylation therapies and designing new rational combinations
to enhance response rates continues to be a promising avenue for AML treatment.</span></p>
<p class="MsoNormal"><span face=""Arial",sans-serif"> </span></p>
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dioxygenases. <i>Cancer Cell</i>,<i> 19</i>(1), 17-30. </span><span face=""Arial",sans-serif"><a href="https://doi.org/10.1016/j.ccr.2010.12.014">https://doi.org/10.1016/j.ccr.2010.12.014</a> <o:p></o:p></span></p><p class="EndNoteBibliography" style="margin-left: 0.5in; text-indent: -0.5in;"><br /></p><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i>Authored by: <b>Alba Rodriguez-Meira, PHD</b>, ISEH Publications Committee and <b>Efosa Enoma</b>, DFCI, Harvard</i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i><br /></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="color: #666666; font-family: arial;"><i style="color: #757575;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></span></div>
<!--[if supportFields]><span style='font-size:11.0pt;line-height:107%;
font-family:"Arial",sans-serif;mso-fareast-font-family:Calibri;mso-fareast-theme-font:
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AR-SA'><span style='mso-element:field-end'></span></span><![endif]-->ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-87111266700616868132022-09-01T11:03:00.003-05:002022-09-02T11:02:13.924-05:00Thank You to our 2022 ISEH Scientific Meeting Sponsors and Supporters<p></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhGmEBMrEeLKzDUsVuVefnf-B1x8Swp9KJ-m_c5A0kzqdT7me-rvRMCag9mNGfhO_V-c9NFhhiZ2XUeyeJVSCHbrA8DUi27eMsvdd57knstV83IdPLNU9QXilaDoBNmm8-nug1OjDQT27J90Cy6dkqgjwvbFAJpUpWqnrJvakgmeK2N_REgmzaK7QyGtw/s1200/ISEH_758735-21_AnnualMeeting2022_WB-1200x628%20Facebook.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="628" data-original-width="1200" height="335" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhGmEBMrEeLKzDUsVuVefnf-B1x8Swp9KJ-m_c5A0kzqdT7me-rvRMCag9mNGfhO_V-c9NFhhiZ2XUeyeJVSCHbrA8DUi27eMsvdd57knstV83IdPLNU9QXilaDoBNmm8-nug1OjDQT27J90Cy6dkqgjwvbFAJpUpWqnrJvakgmeK2N_REgmzaK7QyGtw/w640-h335/ISEH_758735-21_AnnualMeeting2022_WB-1200x628%20Facebook.jpg" width="640" /></a></div><p></p><p><span style="font-family: arial;">The ISEH 51st Annual Scientific Meeting returns in-person this year for the first time since 2019. We're continuing our celebration of 50 years with an</span><span style="font-family: arial;"> </span><span style="font-family: arial;"><a href="https://www.iseh.org/page/2022Program" target="_blank"><span>exciting program</span></a></span><span style="font-family: arial;"> </span><span style="font-family: arial;">including career and technology sessions, as well as talks and poster presentations from trainees, new investigators and leaders in the field.</span></p><div><span style="font-family: arial;">On behalf of the ISEH Board of Directors, volunteers, and staff, we'd like to thank our 2022 sponsors and exhibitors, seen below. We hope to see you all in New York, USA in 2023!</span></div><div><span style="font-family: arial;"><br /></span></div><div><span style="font-family: arial;"><h1 style="background-color: white; box-sizing: border-box; font-family: OpenSansSemibold, Arial, Helvetica, sans-serif; font-weight: 400; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;">ISEH 51st Annual Scientific M<span style="box-sizing: border-box;">ee</span></span></span></span><span style="box-sizing: border-box;"><span style="box-sizing: border-box;">ting</span></span> <span style="box-sizing: border-box;">Spo</span><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;">nsors and Exhibitors</span></span></span></span><em style="box-sizing: border-box; font-family: Arial; font-size: 16px;"> </em></h1><h3 style="background-color: white; box-sizing: border-box; font-family: OpenSansSemibold, Arial, Helvetica, sans-serif; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"><span style="box-sizing: border-box; font-size: 16px;"><em style="box-sizing: border-box;"><span style="font-weight: 400;">This program is supported by an independent medical education grant from the </span>Company of Biologists<span style="font-weight: 400;">.</span></em></span></span></span></span></span></h3><h3 style="background-color: white; box-sizing: border-box; font-family: OpenSansSemibold, Arial, Helvetica, sans-serif; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"><span style="box-sizing: border-box; font-size: 16px;"><em style="box-sizing: border-box;"><span style="font-weight: 400;">Funding for this conference was made possible (in part) by 1R13HL165842 from the </span>National Heart Lung and Blood Institute (NHLBI)<span style="font-weight: 400;">. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.</span><br style="box-sizing: border-box;" /></em></span></span></span></span></span></h3><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"> </span></span></span></span></p><div style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px;"><img alt="" height="66" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2021_virtual_meeting/2021_buttons/button_platinum-level.png" style="box-sizing: border-box; display: block; margin-left: auto; margin-right: auto;" width="248" /></div><div style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"> </div><div style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px;"><img alt="" height="153" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/sponsors/janssen_oncl_prof_rgb_blu.jpg" style="box-sizing: border-box; display: block; height: 153px; margin-left: auto; margin-right: auto; width: 350px;" width="350" /> <hr style="box-sizing: border-box;" /><br style="box-sizing: border-box;" /> <br style="box-sizing: border-box;" /><img alt="Gold Sponsors" height="63" src="https://cdn.ymaws.com/iseh.site-ym.com/resource/resmgr/2021_virtual_meeting/2021_buttons/2021_gold_level.png" style="box-sizing: border-box; display: block; margin-left: auto; margin-right: auto;" width="156" /><br style="box-sizing: border-box;" /><br style="box-sizing: border-box;" /> <img alt="University of Edinburgh" height="56" src="https://cdn.ymaws.com/iseh.site-ym.com/resource/resmgr/2022_meeting/sponsors/university_of_edinburgh2.jpg" style="box-sizing: border-box; display: block; margin-left: auto; margin-right: auto;" width="350" /> <br style="box-sizing: border-box;" /><br style="box-sizing: border-box;" /></div><hr style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px;" /><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px;"> </p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px;"><img alt="" height="66" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2021_virtual_meeting/2021_buttons/2021_silver_level3.png" style="box-sizing: border-box; display: block; margin-left: auto; margin-right: auto;" width="202" /></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px;"> </p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"> </span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"><img alt="" src="https://www.iseh.org/resource/resmgr/2022_meeting/sponsors/logo_bcls_vertical.jpg" style="box-sizing: border-box; height: 125px; width: 200px;" /></span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"> </span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2020_new_york/sponsorlogos/sponsor_logo_page.png" style="box-sizing: border-box; height: 160px; width: 240px;" /></span></span></span></span></p><hr style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px;" /><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"> </span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2021_virtual_meeting/2021_buttons/2021_bronze_level.png" style="box-sizing: border-box;" /></span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"> </span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box;"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/sponsors/bcuk_logo_cmyk_master_red_po.jpg" style="box-sizing: border-box; height: 300px; width: 170px;" /></span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"> </span></span></span></span></p><hr style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px;" /><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"> </p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2021_virtual_meeting/2021_buttons/2021_friends_of_iseh2.png" style="box-sizing: border-box;" /></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"> </p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/sponsors/elife-full-color-horizontal-.png" style="box-sizing: border-box; height: 119px; width: 300px;" /></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/sponsors/missionbio-logo_final_corpor.jpg" style="box-sizing: border-box; height: 72px; width: 450px;" /></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"> </p><hr style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px;" /><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"> </p><h2 style="background-color: white; box-sizing: border-box; font-family: OpenSansSemibold, Arial, Helvetica, sans-serif; text-align: center;"><span style="box-sizing: border-box;"><span style="box-sizing: border-box; font-family: Arial;">Exhibitors</span></span></h2><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"> </p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"> </p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/logos/10x_genomics_logo.png" style="box-sizing: border-box; height: 125px; width: 185px;" /></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"> <span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"> <img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/sponsors/agilent_logo_tagline_cmyk__0.jpg" style="box-sizing: border-box; height: 203px; width: 350px;" /></span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/sponsors/avidity-logo-color-large-tm.png" style="box-sizing: border-box; height: 97px; width: 350px;" /></span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"> </span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"> </span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"> <img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/sponsors/logo_bcls_horizontal.jpg" style="box-sizing: border-box; height: 86px; width: 350px;" /></span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"> </span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"><img alt="" src="https://www.iseh.org/resource/resmgr/2022_meeting/logos/charles_river_logo.jpg" style="box-sizing: border-box; height: 80px; width: 306px;" /></span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"> </span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/sponsors/experiemental_hematology_log.jpg" style="box-sizing: border-box;" /></span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"> </span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/sponsors/stemcell.logo-jpg.jpg" style="box-sizing: border-box; height: 71px; width: 350px;" /></span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"> </span></span></span></span></p><p style="background-color: white; box-sizing: border-box; font-family: "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 14px; text-align: center;"><span style="box-sizing: border-box; font-family: Arial;"><span style="background-color: #122d50; box-sizing: border-box;"><span style="background-color: white; box-sizing: border-box;"><span style="box-sizing: border-box; color: #003b6a;"><a href="https://www.thermofisher.com/uk/en/home/clinical/cell-gene-therapy.html?icid=fl-bid-cellandgenetherapy" style="box-sizing: border-box; color: #00adc7; cursor: pointer; text-decoration-line: none; transition: color 0.3s ease 0s, text-decoration 0.3s ease 0s;" target="_blank"><img alt="" src="https://cdn.ymaws.com/www.iseh.org/resource/resmgr/2022_meeting/logos/thermo_fisher_scientific.jpg" style="box-sizing: border-box; height: 65px; width: 300px;" /></a><br style="box-sizing: border-box;" /><br style="box-sizing: border-box;" /><img alt="" height="64" src="https://cdn.ymaws.com/iseh.site-ym.com/resource/resmgr/2022_meeting/sponsors/university_of_edinburgh2.jpg" style="box-sizing: border-box;" width="400" /></span></span></span></span></p></span></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-41608950888358108322022-08-26T09:07:00.001-05:002022-08-26T09:07:18.772-05:002022 Interview Spotlight Series: Part IV<p><span style="font-family: arial;"><span>This week on Simply Blood we close out our 2022 Interview Spotlight Series! Part IV features the ISEH 2022 Donald Metcalf Award Winner: <b>Jim Palis, MD</b>. Click below to listen as Dr. Palis answers questions about his scientific passions, career path, mentorship and more. Interested in hearing more about Dr. Palis' fascinating work? </span><span style="background-color: white; color: #757575;"> </span><a href="https://www.iseh.org/page/2022Program" style="background: rgb(255, 255, 255); color: #f53e3e; text-decoration-line: none;"><span style="color: #c77ddc;">Don’t miss his session at the ISEH 51st Annual Scientific Meeting this September</span></a><span style="background-color: white; color: #757575;">!</span></span></p><p><span style="font-family: arial;"><span style="background-color: white; color: #757575;"><br /></span></span></p><p></p><div class="separator" style="clear: both; text-align: center;"><iframe allowfullscreen="" class="BLOG_video_class" height="365" src="https://www.youtube.com/embed/vX9NEHLUEVI" width="438" youtube-src-id="vX9NEHLUEVI"></iframe></div><br /><div class="separator" style="clear: both; text-align: center;"><br /></div><p></p><div style="background-color: white;"><div style="color: #757575; font-family: arial; font-size: 15px;"><b><br /></b></div><div style="color: #757575; font-family: arial; font-size: 15px;"><b><div class="separator" style="clear: both; text-align: center;"><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhd6HUtiok4qbpSbcmfyTlNNFsYv-buEUaw2G3-SEr92bm6lfRIrWLme_JJywxkWE8yZ3CiN68ds62ksU84LHMC2IHfFIRNO-xEYfv-AP1qkpIVJtHffoarDnxB6dNbQbiuEGEYkKola0G6Mx4JnZk3qV_CAYvOb-Yn9p4HcQGSK4BYHmSg4sb75dra7Q/s4119/JimPalis.jpeg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="4119" data-original-width="2770" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhd6HUtiok4qbpSbcmfyTlNNFsYv-buEUaw2G3-SEr92bm6lfRIrWLme_JJywxkWE8yZ3CiN68ds62ksU84LHMC2IHfFIRNO-xEYfv-AP1qkpIVJtHffoarDnxB6dNbQbiuEGEYkKola0G6Mx4JnZk3qV_CAYvOb-Yn9p4HcQGSK4BYHmSg4sb75dra7Q/w134-h200/JimPalis.jpeg" width="134" /></a></div><br /><br /></div><br />Jim Palis, MD</b></div><div style="color: #757575; font-family: arial; font-size: 15px;">Professor, Department of Pediatrics, Hematology and Oncology</div><div style="color: #757575; font-family: arial; font-size: 15px;">Professor, Department of Pathology and Laboratory Medicine</div><div><span style="color: #757575; font-family: arial;"><span style="font-size: 15px;">University of Rochester Medical Center</span></span></div><div><span style="color: #757575; font-family: arial;"><span style="font-size: 15px;">Rochester, NY, USA</span></span></div></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i><span style="color: #999999;"><br /></span></i></span></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><p><span style="font-family: arial;"></span></p><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i><span style="color: #999999;">Interviewed by Stephen Loughran of the </span></i><i><span style="color: #999999;">ISEH New Investigators Committee</span></i></span></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-23255413000597249412022-08-23T13:37:00.006-05:002022-08-23T13:37:47.456-05:002022 Interview Spotlight Series: Part III<p><span style="font-family: arial;">This week on Simply Blood we continue our 2022 Interview Spotlight Series. In Part III we are featuring the ISEH 2022 McCulloch & Till Awardee: Louise Purton, PhD. Here, Dr. Purton answers questions about her scientific achievements, personal passions, mentorship, and more. Interested in hearing more about Dr. Purton’s fascinating work? </span><a href="https://www.iseh.org/page/2022Program" style="font-family: arial;"><span style="color: #c77ddc;">Don’t miss her session at the ISEH 51st Annual Scientific Meeting this September</span></a><span style="font-family: arial;">!</span></p><span style="font-family: arial;"><br /></span><p></p><div class="separator" style="background-color: white; clear: both; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px; text-align: center;"><div class="separator" style="clear: both; text-align: center;"><iframe allowfullscreen="" class="BLOG_video_class" height="366" src="https://www.youtube.com/embed/zvG7AH0sIcA" width="441" youtube-src-id="zvG7AH0sIcA"></iframe></div><br /></div><div class="separator" style="clear: both; text-align: center;"><br /></div><br /><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><b><span style="font-family: arial;"><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjFRkQff7wRkuxTe5zAYx2zOtCNEkV9Hmx9h_hps4t-gs3HUgpNKplbLrGuHjs3RuS2H1BynyCPJmuIPj4E5dfCSi4i6ncesJQRsZLPGqVfCKXhRCIQ0-liVk4VzvkE2FiIgt6m2rfs6ZUssktGP3AEo34WmKohBVtR6I5hXtOwqzF86J9FonLmKwjXGw/s657/Louise%20Purton%20head%20shot%202018.JPG" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="591" data-original-width="657" height="180" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjFRkQff7wRkuxTe5zAYx2zOtCNEkV9Hmx9h_hps4t-gs3HUgpNKplbLrGuHjs3RuS2H1BynyCPJmuIPj4E5dfCSi4i6ncesJQRsZLPGqVfCKXhRCIQ0-liVk4VzvkE2FiIgt6m2rfs6ZUssktGP3AEo34WmKohBVtR6I5hXtOwqzF86J9FonLmKwjXGw/w200-h180/Louise%20Purton%20head%20shot%202018.JPG" width="200" /></a></div><br />Dr Louise Purton</span></b></div><div style="background-color: white;"><div><div><span face="Arial, Tahoma, Helvetica, FreeSans, sans-serif" style="color: #757575;"><span style="font-size: 15px;">Head, Stem Cell Regulation Unit </span></span></div><div><span face="Arial, Tahoma, Helvetica, FreeSans, sans-serif" style="color: #757575;"><span style="font-size: 15px;">St. Vincent's Institute of Medical Research</span></span></div></div><div><span face="Arial, Tahoma, Helvetica, FreeSans, sans-serif" style="color: #757575;"><span style="font-size: 15px;">University of Melbourne, Melbourne, Australia</span></span></div></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><p><span style="font-family: arial;"></span></p><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i><span style="color: #999999;">Interviewed by Alejo Rodriguez-Fraticelli, </span></i><i><span style="color: #999999;">ISEH New Investigators Committee</span></i></span></div><br />ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-27658830228664308912022-08-11T13:20:00.000-05:002022-08-11T13:20:04.018-05:002022 Interview Spotlight Series: Part II<p><span style="font-family: arial;">This week on Simply Blood we continue our 2022 Interview Spotlight Series. In Part II we are featuring the ISEH 2022 Janet Rowley Awardee: David Kent, PhD. Here, Dr. Kent answers questions about his scientific passions, career path, mentorship and more. Interested in hearing more about Dr. Kent’s fascinating work? </span><a href="https://www.iseh.org/page/2022Program" style="font-family: arial;"><span style="color: #c77ddc;">Don’t miss his session at the ISEH 51st Annual Scientific Meeting this September</span></a><span style="font-family: arial;">!</span></p><p></p><div class="separator" style="clear: both; text-align: center;"><iframe allowfullscreen="" class="BLOG_video_class" height="358" src="https://www.youtube.com/embed/5n9q1x7VaTw" width="431" youtube-src-id="5n9q1x7VaTw"></iframe></div><br /><span style="font-family: arial;"><br /></span><p></p><div class="separator" style="background-color: white; clear: both; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px; text-align: center;"><br /></div><p><span style="font-family: arial;"><br style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;" /></span></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjylcQQkocKxptMZrA-As-npnB7Dfeln2agqdQThGry1GxLS1OMXBIm9TeSLcB5CFlNsTflJvcD3UnE0bZYlKp2kFA-w42_a4JdDFXNdsXYQlfNlkLYSojmBy0g7gnv7lc6YjsNG4a662v65VrMSg8EZlo5HOMGRtzPVSFp8cL3OaH16CHXQ90_KscUQg/s198/Kent_HS.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="198" data-original-width="167" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjylcQQkocKxptMZrA-As-npnB7Dfeln2agqdQThGry1GxLS1OMXBIm9TeSLcB5CFlNsTflJvcD3UnE0bZYlKp2kFA-w42_a4JdDFXNdsXYQlfNlkLYSojmBy0g7gnv7lc6YjsNG4a662v65VrMSg8EZlo5HOMGRtzPVSFp8cL3OaH16CHXQ90_KscUQg/w169-h200/Kent_HS.jpg" width="169" /></a></div><br /><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><b><span style="font-family: arial;">Dr David Kent</span></b></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><div>York Biomedical Research Institute</div><div>Department of Biology</div><div>University of York, York, UK</div><div><br /></div></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><br /></div><p><span style="font-family: arial;"></span></p><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><i><span style="color: #999999;">Interviewed by Francois Mercier, </span></i><i><span style="color: #999999;">ISEH New Investigators Committee</span></i><i><span style="color: #999999;"> & Beth Psaila, ISEH Junior PI Committee. </span></i></span></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-29133158880583792522022-08-03T16:53:00.004-05:002022-08-03T17:15:23.190-05:00ISEH 2022 Junior Faculty Session Highlights<p><b></b></p><div class="separator" style="clear: both; text-align: center;"><b><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgI4iSzh6VKE8hL2MYGJ8j_EhS9x7ztEWPkwIVw-UVXfYuC7xMmpnvUfREGQMDKStnIamcLl-pMpuQ5iOrDjmLC2IghR3dP_nTrnXdftXMyUZEMzqZl9hJTwv3DwDxTCQZrSJVausQ0tpAn04xsGvq8IYCsCLBeIOhIbaKK7jUazJ20JCsr37mNV9MrAQ/s600/ISEH_758735-21_AnnualMeeting2022_WB-600x200%20Email%20Header.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="200" data-original-width="600" height="189" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgI4iSzh6VKE8hL2MYGJ8j_EhS9x7ztEWPkwIVw-UVXfYuC7xMmpnvUfREGQMDKStnIamcLl-pMpuQ5iOrDjmLC2IghR3dP_nTrnXdftXMyUZEMzqZl9hJTwv3DwDxTCQZrSJVausQ0tpAn04xsGvq8IYCsCLBeIOhIbaKK7jUazJ20JCsr37mNV9MrAQ/w565-h189/ISEH_758735-21_AnnualMeeting2022_WB-600x200%20Email%20Header.jpg" width="565" /></a></b></div><b><br /> Junior PI Networking Event – Raging Bull, Edinburgh, Scotland (Friday Sept. 2, 20:00-23:00)</b><p></p><p>The newly formed Junior PI committee is following on from its successful webinar series highlighting the “<i><a href="https://www.iseh.org/page/ISEHWebinars">Journey and Lessons Learned</a></i>” by hosting a dedicated Junior PI Networking Event at this year’s ISEH Annual Meeting to build a strong, supportive community of junior faculty worldwide</p><p>Starting out as a new PI can be a daunting proposition with challenges including moving to an entirely new institute, reducing hands-on time in the laboratory, securing competitive grant funding and the need to recruit new staff and students. All whilst sustaining scientific productivity and maintaining a work/life balance. It pays to remember that science at its core is a ‘<i>human business</i>’, with building meaningful relationships, a sense of community and learning through shared experience all being essential to the progress of science. </p><p>Whilst the sharing of knowledge has been accelerated and democratized through the exponential growth of online lab meetings and conferences courtesy of COVID-19, it has done little to build these meaningful relationships especially for new PIs. Indeed, it is often the free flow of people and ‘corridor conversations’ in between the science together with organised mixers and networking events that fertilizes new ideas, innovation and new collaborations. </p><p>The goal of our event is to create a venue for these valuable interactions at our Annual Meeting. At the Networking Event, attendees will be able to:</p><p>1) Create networks of mutual support for junior faculty through shared experience in establishing an independent research group. e.g., Career journeys and lessons learned on the way to independence.</p><p>2) Facilitate and foster new scientific collaborations between junior faculty, and provide opportunities for ‘corridor conversations’ between junior faculty who may not otherwise be able to meet in person.</p><p>3) Meet with selected senior faculty from the ISEH community, the Editorial Board of Experimental Hematology, and the Blood Cancer UK funding agency.</p><p>If you already identify as a Junior PI or are about to embark on the journey to independence, please register your interest for this <i>FREE</i> event at the <a href="https://theragingbulledinburgh.co.uk/">Raging Bull Function Room</a>, just a short 0.2 mile walk from the <a href="https://www.eicc.co.uk/">conference center</a>. </p><p> </p><p><b>Junior PI Career Session ‘Meet the Editors: Insights from Behind the Scenes’ – Edinburgh International Conference Centre Venue (Friday Sept. 2, 13:00-14:00)</b></p><p>As scientists, we are all under pressure to publish papers; the stress can be greater for junior PIs preparing to submit papers generated in their own lab. During this year’s ISEH Annual Meeting, the Junior PI committee will host a discussion forum in which junior faculty will have the opportunity to learn and discuss editorial processes with academic scientists who also have experience as journal editors. </p><p>The event aims to help junior PIs with manuscript preparation by getting to know editorial processes in depth from the people making the decisions. As panellists, we will welcome senior PIs, Bertie Göttgens (Blood), Louise Purton (Experimental Hematology), Emmanuelle Passegué (Journal of Experimental Medicine) and Toshio Suda (Editor-in-Chief, Experimental Hematology) who serve on editorial board of prestigious journals in the hematology field. </p><p>Some potential topics which may be addressed in the session will be:</p><div style="text-align: left;">1) When and how to appeal an editorial decision?<br />2) How important is the cover letter and how to maximize its effectiveness?<br />3) How are pre-submission enquiries handled and how effective are they really?<br />4) When and how can a junior PI become a member on an editorial board of a journal?<br />5) Does anonymous review affect editorial decisions?<br />6) How do editors weigh reviewer comments and their own instincts in making a decision?</div><p>This event will be an in-person, panel format + Q&A event with a brief introduction from each editor on their journal and the editorial process. Our panellists can answer your questions about their journals, discuss the submission and review processes, and provide attendees with behind-the-scenes advice on how to increase the likelihood of publication.</p><p>If you identify as a Junior PI or are struggling to prepare and submit your paper as corresponding author, please join us for this exciting and interactive session on Friday, 2nd September, 13:00-14:00. No pre-registration or ticket is required to attend!</p>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com1tag:blogger.com,1999:blog-7493723606219936779.post-47163267638287915822022-07-29T12:43:00.003-05:002022-07-29T12:43:36.810-05:00 2022 Interview Spotlight Series: Part I<p><span style="font-family: arial;">This week on Simply Blood we are kicking off our 2022 Interview Spotlight Series. In Part I we are featuring the ISEH 2022 New Investigator’s Invitee: Christina Halsey, PhD. Here, Dr. Halsey answers questions about her scientific passions, career path, mentorship and more. Interested in hearing more about Dr. Halsey’s fascinating work? </span><a href="https://www.iseh.org/page/2022Program" style="font-family: arial;"><span style="color: #c77ddc;">Don’t miss her session at the ISEH 51st Annual Scientific Meeting this September</span></a><span style="font-family: arial;">!</span></p><div class="separator" style="clear: both; text-align: center;"><iframe allowfullscreen="" class="BLOG_video_class" height="364" src="https://www.youtube.com/embed/QziGnI5epsY" width="438" youtube-src-id="QziGnI5epsY"></iframe></div><br /><div><br /></div><div><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgRArpGKgqAiOEoNDGqUJ4tktoSzSRMah_ThiS1-KnCaaLuFC7dCp-lLFfy1qxZk7C95icro3cndqtSYt7dlR0_ADc0J2f5wDhk0do4hddATdBGvK6MbExG1O5RinoIOfnpueYQpTeyD4mMDPpcolieIZ42cEvNgF_0M_-ssjVdmsMbEruR76IRpV1owA/s359/Halsey.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="359" data-original-width="239" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgRArpGKgqAiOEoNDGqUJ4tktoSzSRMah_ThiS1-KnCaaLuFC7dCp-lLFfy1qxZk7C95icro3cndqtSYt7dlR0_ADc0J2f5wDhk0do4hddATdBGvK6MbExG1O5RinoIOfnpueYQpTeyD4mMDPpcolieIZ42cEvNgF_0M_-ssjVdmsMbEruR76IRpV1owA/w133-h200/Halsey.jpg" width="133" /></a></div><br /><div><br /></div><div><b><span style="font-family: arial;">Dr Christina Halsey</span></b></div><div><span style="font-family: arial;">Professor of Paediatric Haemato-Oncology</span></div><div><span style="font-family: arial;">Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre</span></div><div><span style="font-family: arial;">University of Glasgow, UK</span></div><div><br /></div><div><br /></div><div><br /></div><div><br /></div><div><br /></div><div><br /></div><div><br /></div><div><br /></div><div><br /></div><div><span style="font-family: arial;"><i><span style="color: #999999;">Interviewed by Camille Malouf, </span></i><i><span style="color: #999999;">ISEH New Investigators Committee</span></i><i><span style="color: #999999;"> & Alasdair Duguid, PhD Student in the labs of Christina Halsey and Katrin Ottersbach.</span></i></span><div><br style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;" /></div></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0tag:blogger.com,1999:blog-7493723606219936779.post-43647571752356871132022-07-15T14:25:00.000-05:002022-07-15T14:25:34.457-05:00Coming Back to In-Person Hematology: ASH 2021, A Re-Cap<div class="separator" style="clear: both; text-align: center;"><a href="http://iseh.org/iseh2022" imageanchor="1" style="margin-left: 1em; margin-right: 1em;" target="_blank"><img border="0" data-original-height="200" data-original-width="600" height="214" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhqsFqh0pjxjoMKztDB2KSfir3yPWubd6OMieY2gOcPfsHiTAOPRd3uJc_udchd-cQ2PRgFZgnBoz2stCbZ2CIartU0TCNkjNKNpdoir6KepOgYB7sDeCzmr1YBG4AEPLZvQWZshbP_ZLgeDt_an3chYex42R7QaTJ3pnul66erElufKJahXxJ6aSZ9uA/w640-h214/ISEH%202022%20Email%20Banners%20(2).png" width="640" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><span style="font-family: arial;">With relaxing COVID-19 restrictions toward the end of 2021, the American Society of Hematology (ASH) made a decision to offer a hybrid online/in-person format for the first time in Atlanta, USA. With this decision, ASH 2021 became a reference point on how to organize a hybrid meeting, and how to bring the hematology community together by engaging attendees both in-person and remotely.<br /><br />ISEH members had the chance to attend the best experimental hematology sessions both online and in-person, a number of which focused on the biology of clonal hematopoiesis and new molecular mechanisms driving malignant transformation, and are highlighted below. We also interviewed our ISEH member Dr. Alba Rodriguez-Meira, who presented her work through one of the Plenary Sessions at ASH 2021. <br /><br /><b>A Few Highlights from ASH21 Sessions <br /></b><br />Taking advantage of state-of-the-art whole-genome sequencing technologies, Dr. Emily Mitchell from the Campbell Lab (Sanger Institute, Cambridge; Abstract 598) detailed their group’s study of greater than 3500 genomes of single clone derivatives of hematopoietic stem and progenitor cells from 10 hematologically normal subjects aged 0 to 81 years of age and determined that clonal diversity universally decreased with age, a process that is underpinned by pervasive positive selection on genetic drivers that are far greater in number than has been understood to date. <br /><br />Complementing this approach, Dr. Caroline Watson from the Blundell Lab (University of Cambridge; Abstract 599) presented their group’s longitudinal study in which serial peripheral blood samples were retrospectively sequenced for myeloid-associated driver mutations and chromosomal abnormalities in patients prior to and up to the point of being diagnosed with acute myeloid leukemia (AML). By inferring the fitness advantages of distinct genetic subclones, they traced back pre-leukemic mutations (such as those found in clonal hematopoiesis of indeterminate potential (CHIP)) to approximately 20 years before a second genetic hit was acquired, and 50 years before the development of AML. Importantly, the fitness advantage of early clones influenced the onset of AML development, providing support for the importance and role of risk stratification and early intervention with such surveillance strategies.<br /><br />Novel methodologies to assess the fitness effects of CHIP-related mutations were also presented. For example, Dr. Kristina Kirschner (CRUK Beatson Institute, University of Glasgow; pre-meeting workshop) presented a new computational method to extract fitness effects from longitudinal sequencing data using Bayesian inference while considering individual mutational context and co-occurrence of mutations, and thus quantify the growth potential of variants within each individual. Their groups’ work showed that gene-specific fitness differences can outweigh inter-individual variation and supports a basis for personalized clinical management. Jk Gopakumar from the Jaiswal Lab (Stanford University; Abstract 597) introduced PACER, a new method to infer clonal expansion rates from serial single timepoint bulk whole-genome sequencing data. Their group applied a genome-wide association study to identify germline variants that correlated with PACER-estimated clonal expansion rate, and found that a common single nucleotide polymorphism in the promoter of TCL1A protected against TET2-mediated clonal expansion. <br /><br />Several groups also focused on the underlying mechanisms of CHIP-mediated clonal expansions with elegant functional studies. For example, probing the methylation-independent effect of DNMT3A mutations using catalytically inactive mutants (presented by Won Kyun Koh from the Challen Lab, Washington University School of Medicine, Abstract 24), mechanisms of inflammation-related clonal advantage of DNMT3A mutations driven by p53 stabilization (presented by Dr. Christine Zhang, Challen Lab, Abstract 600) and fatty bone marrow (presented by Naama Zioni, Shlush Lab at the Weizmann Institute, Abstract 596).<br /><br />Among studies focused on reconciling molecular mechanisms driving disease included one from Dr. Andreea Reilly, from the Doulatov Lab (University of Washington; Abstract 502), whose group showed how loss of LMNB1, a gene commonly deleted by 5q-MDS, leads to loss of self-renewal, myeloid bias, changes in the 3D genome organization responsible for aberrant lineage specification and characteristic morphological findings among neutrophils in this MDS subtype. <br /><br />Many of the main scientific sessions at the Presidential Symposium focused on the biology of TP53, the most recurrently mutated oncogene in cancer and associated with extremely poor prognosis in hematological malignancies. Dr. Carol Prives discussed fundamental biological mechanisms of p53-driven tumorigenesis and Dr. Guillermina Lozano and Dr. Matthew Davids, the latest therapeutic approaches related to p53-mutant inbition. Dr. Alba Rodriguez-Meira from the Mead Lab (University of Oxford, Abstract 3) identified inflammatory stimuli that drive disease transformation in the context of TP53-mutated myeloproliferative neoplasms.<a href="file:///C:/Users/aisch/AppData/Local/Microsoft/Windows/INetCache/Content.Outlook/AAM97M9M/ExpHematology_ASHPost_v4_ARM.docx#_msocom_1">[RMA1]</a> We had a chance to interview her during the conference, and you can read her experience below. <br /><br /><b>Interview with Dr. Alba Rodriguez Meira at ASH21</b><br /><br />How did you enjoy ASH this year? <br /><br /><i>It was an amazing experience to finally see colleagues after two years in a much more interactive way. I just moved to the US so I can meet US colleagues in person now and extend my network. </i><br /><br />What was the ASH highlight for you? <br /><br /><i>Being in the backstage room in the plenary session before my talk seeing all the preparations that go into a Plenary Session. I also got a lot of energy from interactions with colleagues and feeling alive in the scientific community.</i><br /><br />How did you manage to have your abstract selected for the plenary session? <br /><br /><i>It was just the right combination of innovative technology and interesting biology that was timely with current trends in hematology research looking into TP53 mutated neoplasms.</i><br /><br />How was your experience giving this talk? <br /><br /><i>Honestly, it was very overwhelming; the music upon entry was very intimidating but I thought it was such a good opportunity. I actually enjoyed the session very much at the end.</i><br /><br />What helped you to deliver a good talk? <br /><br /><i>Thanks for saying it was a good talk! Good training during my graduate studies was essential. I had a lot of opportunities to give talks including frequently presenting to senior scientific committees at work. My mentor helped me practice and gave me tips, in addition to a course on public speaking, which helped me to not be nervous once on stage and to deliver the talk as I had prepared for it.</i><br /><br />How was Atlanta as the host city? <br /><br /><i>The Congress Centre was well prepared for a meeting like this. It is overwhelmingly big and they were ready to host people in a structured way.</i><br /><br />How did you navigate COVID-19 and the in-person meeting?<br /><br /><i>ASH was well prepared with outstanding access to onsite testing, great compliance with masks, which altogether created a safe environment. This setup really set the tone for the future of hybrid conferences, demonstrating how these arrangements work well. It was also amazing to get to see ISEH members in person and to bring the ISEH community together at this meeting. </i><br /><br /><b>Summary and next steps for ISEH 2022 <br /></b><br />In total, around 13,250 people joined ASH 2021 in person and an additional 16,550 online. The hybrid format was crucial for those unable to travel due to ongoing travel restrictions at the time, and to increase accessibility to those unable to fund expensive travel to the US.<br /><br />The ASH virtual platform provided many opportunities for interaction with the speakers and other attendees, such as the ASH internal networking platform, interactive sessions such as “Meet-the-scientist” and live Q&A. All of those options helped engage the only-virtual audience in the meeting.<br /><br />However, going back to “in-person hematology” highlighted the importance of in-person meetings, where many interactions occur through casual lunches, drinks during the poster session and afternoon coffees. Those types of interactions are still difficult to replace by current online platforms. <br /><br />We hope that the success of the ASH hybrid meeting will pave the way for the upcoming ISEH 2022 Annual Meeting, which will also be held in a hybrid format in Edinburgh in September 2022. Looking to learn more about ISEH's hybrid approach and our scientific meeting content for ISEH 2022? Visit <a href="http://www.iseh.org/iseh2022">www.iseh.org/iseh2022</a> to learn more and register today!</span><div style="mso-element: comment-list;"><div style="mso-element: comment;"><div class="msocomtxt" id="_com_1" language="JavaScript">
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</div><div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><div class="separator" style="clear: both; text-align: center;"><div class="separator" style="clear: both;"><br /></div><br /></div></div><div style="background-color: white; color: #757575; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 15px;"><span style="font-family: arial;"><br /></span></div><div style="background-color: white;"><div style="color: #757575; font-family: arial; font-size: 15px;"><i><br />Blog post contributed by: </i></div><div style="color: #757575; font-family: arial; font-size: 15px;"><div>Kristina Kirschner, PhD - @krikirschner</div><div>Group Leader, Institute of Cancer Sciences/ CRUK Beatson Institute</div><div>University of Glasgow, Scotland</div><div><br /></div><div>Alba Rodriquez Meira - @AlbaRMeira</div></div><div><span style="color: #757575; font-family: arial;"><span style="font-size: 15px;">Sir Henry Wellcome Fellow, Dana Farber Cancer Institute</span></span></div><div style="color: #757575; font-family: "Times New Roman"; font-size: 15px;"><span style="font-family: arial;">Cambridge Stem Cell Institute, United Kingdom</span></div><div style="color: #757575; font-family: "Times New Roman"; font-size: 15px;"><span style="font-family: arial;"><br /></span></div><div style="color: #757575; font-family: "Times New Roman"; font-size: 15px;"><span style="font-family: arial;"><br /></span></div><div style="color: #757575; font-family: "Times New Roman"; font-size: 15px;"><span style="font-family: arial;"><br /></span></div><div style="color: #757575; font-family: "Times New Roman"; font-size: 15px;"><span style="font-family: arial;"><br /></span></div><div style="color: #757575; font-family: "Times New Roman"; font-size: 15px;"><i style="font-family: arial;">Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.</i></div></div></div>ISEH Headquartershttp://www.blogger.com/profile/07250627584021635044noreply@blogger.com0