simply blood

This week on Simply Blood we are continuing our Interview Spotlight Series. In Part II we are featuring the ISEH 2024 Donald Metcalf Awardee:  Emmanuelle Passegué, PhD. Dr.  Passegué answers questions about her scientific passions, career path, advice for trainees and more! Interested in hearing more about  Dr.  Passegué's work?  Don’t miss her session at the ISEH 53rd Annual Scientific Meeting this September ! Emmanuelle Passegué, PhD Director, Columbia Stem Cell Initiative Columbia University Irving Medical Center 2024 Donald Metcalf Award Recipient Interviewed by Anne Stolz of the ISEH New Investigators Committee. Please note that the statements made by Simply Blood Authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

This week on Simply Blood we are kicking off our Interview Spotlight Series. In Part I we are featuring the ISEH 2024 McCulloch & Till Awardee: Ravindra 'Ravi' Majeti MD, PhD. Dr. Majeti reflects on his scientific achievements, career inspirations, entrepreneurial ventures, and looks towards the future of hematologic research. Interested in hearing more about Dr. Majeti's fascinating work?  Don’t miss his session at the ISEH 53rd Annual Scientific Meeting this September !                                                                                                                                                                                            Ravindra 'Ravi' Majeti MD, PhD RZ Cao Professor of Medicine Chief of the Division of Hematology Member of the Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine 2024 McCulloch & Till Award Recipient Interviewed by Ian Hsu of the  ISEH New Investigators Committe

  Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Elf Lab which is based out of the Huntsman Cancer Institute, University of Utah ( https://www.elflab.org/ ). What does your lab study? The primary focus of my lab is to understand the molecular mechanisms that govern myeloid blood cancers, with particular emphasis on MPNs. The long-term vision of my research program is to elucidate molecular dependencies specific to MPN stem cells (MPN-SCs) that can be targeted for therapeutic intervention with the ultimate goal of eradicating MPN-SCs, sparing normal HSCs, and curing the disease. When I first started my lab, we were particularly interested in how CALR mutations hijack ER stress response pathways to promote survival. Through these studies, we found that though type 1 and type 2 CALR mu

  Assessment of a novel NRAS in-frame tandem duplication causing a myelodysplastic/myeloproliferative neoplasm Cora C.A. Beckmann, Senthilkumar Ramamoorthy, Eirini Trompouki, Wolfgang Driever, Stephan Schwarz-Furlan, Brigitte Strahm, Ayami Yoshimi, Charlotte M. Niemeyer, Miriam Erlacher, Friedrich G. Kapp Myeloproliferative neoplasms (MPNs) and myelodysplastic syndrome (MDS) are rare hematologic disorders in children that can only be cured by hematopoietic stem cell transplantation (HSCT).  The genetics of pediatric MPN and MDS are only partially understood and are extrapolated from epidemiologic studies in older adults.  RAS pathway mutations often occur in pediatric MPN and MDS, and children with predisposition for these conditions often bear germline mutations in components of the RAS signaling pathway.  Led by Dr. Kapp at the Faculty of Medicine, University of Freiburg, the authors describe a 2-year-old patient with pancytopenia, massive splenomegaly with myeloid and erythroid prec

Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Yamazaki Lab which is based out of The Institute of Medical Science, The University of Tokyo in Japan ( https://www.cbms.k.u-tokyo.ac.jp/en/labs/yamazaki/ ). You have quite a unique career path, aren’t you? So when and how did you start considering becoming a PI? I did not think I would be able to become a PI in the past. (*Prof. When he started working in this field, Yamazaki was a technical staff, not even a bachelor's student.) At that time, simply performing experiments was fun, so I did not prioritize obtaining academic degrees. Later, however, I started feeling more fun writing a paper by myself, with which I could connect myself and discuss science with other national and international researchers worldwide. My desire to spre

G-CSF−induced hematopoietic stem cell mobilization from the embryonic hematopoietic niche does not require neutrophils and macrophages   (Ji Wook Kim, Evan A. Fedorova, and Leonard I. Zon) In this issue of Simply Blood, we are highlighting one of the journal’s latest manuscripts by first author Ji Wook Kim. This study was conducted in Dr. Leonard Zon’s laboratory (Department of Stem Cell and Regenerative Biology, Harvard Medical School) and has demonstrated that the Granulocyte colony-stimulating factor (G-CSF) induced hematopoietic stem and progenitor cell (HSPC) mobilization from the embryonic hematopoietic niche in not neutrophil and macrophage depended. The discrepancies in literature suggesting G-CSF either acts directly to mobilize HSPCs or requires myeloid cells has created ambiguity regarding the mechanism of action of G-CSF. Kim et al, developed a stable transgenic line with a heat-inducible csf3b , a zebrafish ortholog of human CSF3 , which translates into G-CSF and confirme