simply blood

Welcome to our monthly Preprint Watch, where we highlight some of the most relevant preprints for the ISEH community! This month we cover some exciting findings on immunotherapy, hematopoietic fetal development and erythropoiesis. If you would like to see your preprint highlighted here, complete this brief form . We are also happy to chat with Dr. Jane Xu, she will tell us more about chromatin accessibility and leukemia development!  From the Simply Blood Community: Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia https://www.biorxiv.org/content/10.1101/2025.03.19.643917v1 From the authors: We developed humanized models to investigate how the developmental origin of hematopoietic stem and progenitor cells influences leukemia initiation, lineage plasticity, and therapeutic response in pediatric leukemias driven by NUP98 fusion oncoproteins. Our study reveals fundamental developmental differences underlying lineage potential and dru...

Espin Lab Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the  Espin Lab   which is based out of Iowa State University. How long have you had your lab? I started my lab in August 2019, so 5.5 years. How many members make up your lab? In the last year, the lab has reduced its size due to four graduations, one retirement, and one postdoc who transitioned to a faculty position, so we are in the process of hiring. Currently, in my lab there are two PhD students, a lab manager, and four undergraduate researchers. However, our lab operates together with the lab of Dr. Clyde Campbell, husband and Assistant Professor at ISU, which adds two more PhD students to the group. Both of our labs work as a team, sharing research resources and mentorship. It is therefore hard to separate the memb...

  This week on Simply Blood, we interviewed last year's Award Winner for Leadership in Mentorship, Ross Levine, MD . Dr. Levine shares lessons learned, advice for those who are beginning with their first hires, and words of wisdom for helping mentees set long-term goals. Learn more about the Levine Lab . Ross Levine, MD Senior Vice President Memorial Hospital Translational Research Blog post contributed by members of the ISEH Junior Investigator Committee. Please note that the statements made by Simply Blood authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

This month, we're featuring a special edition of the Preprint watch, focused exclusively on pathological and malignant hematopoiesis. If you want your research to be featured here, submit this brief form . From the Simply Blood Community: RUNX1::RUNX1T1 Depletion Eliminates Stemness and Induces Bidirectional Differentiation of Acute Myeloid Leukemia https://www.biorxiv.org/content/10.1101/2025.02.13.637937v1 From the authors: “The relevance of continuing expression of fusion genes in primary leukaemic cells has remained unclear. Silencing RUNX1::RUNX1T1 expression in primary AML cells using siRNA-loaded lipid nanoparticles induces substantial changes in chromatin accessibility and therewith associated transcriptional networks linked with granulocytic and eosinophilic differentiation at the complete expense of LSC-enriched populations.” Contact address: o.t.heidenreich@prinsesmaximacentrum.nl Wnt-dependent spatiotemporal reprogramming of bone marrow niches drives fibrosis https://ww...

To science or not to science?  Research in academia is difficult and challenging, but it is also extremely rewarding. We explore the depths of biology to discover something new and exciting. We dream of bringing new concepts to textbooks, or to discover a cure for a disease that impacts us and the people we love. We are constantly learning new things, even long after we have completed our graduate studies. Sometimes, our research goes in the direction we hoped for, but we are often blown away by new findings that challenge the field and what we learn from textbooks. We have a degree of freedom that can be difficult to achieve in other scientific career paths.  Research in academia has a lot of upsides, but like any career, it also comes with downsides. Firstly, salaries in academia are often lower than what the industry can offer us. We work a lot of extra hours that are, most of the time, unaccounted for financially. Finally, there is a constant stress of finding money to fin...

  On behalf of the Awards Committee, ISEH would like to congratulate the recipients of the 2025 ISEH Society Awards which will be presented at the  ISEH 54th Annual Scientific Meeting . Donald Metcalf Award Winner - Constanze Bonifer The recipient of the 2025 Donald Metcalf Award is Dr. Constanze ‘Conny’ Bonifer, for her outstanding work in the fields of epigenetic and gene regulatory processes regulating blood cell development and differentiation, and how these processes go astray in the development of blood cancer. Dr. Bonifer has been a pioneer and world leader in these areas and a source of inspiration and guidance for many scientists working in experimental hematology.  Dr. Bonifer started her scientific career in Germany where she completed her BSc in Cologne and her PhD in Heidelberg. After a postdoctoral fellowship at the Karolinska Institute, Stockholm, Sweden and the National Institute of Medical Research, London, UK, Dr. Bonifer returned to Germany as an Assist...