Preprint Watch: June
Welcome to the Preprint Watch, where we highlight some of the latest and most interesting preprints for the ISEH community. In this issue, we’re highlighting preprints of note from June. If you'd like to submit your preprint, please complete this brief form. STEM AND PROGENITOR CELLS BIOLOGY Hematopoietic stem cells undergo bidirectional fate transitions in vivo https://www.biorxiv.org/content/10.1101/2025.02.23.639689v2 From the authors: Sequential introduction of DNA barcodes in vivo was developed to assess time-dependent changes in cell fate. Clonal phylogenetic tracer (CP-tracer) enabled high-resolution phylogenetic analysis of ∼100,000 subclones derived from ∼500 individual hematopoietic stem cells (HSC). Bidirectional fate transitions between myeloid-biased haematopoietic stem cells (My-HSCs) and lineage-balanced haematopoietic stem cells (balanced-HSCs) were observed. Hhex was identified as a molecular driver of HSC lymphoid competence. GATA2 Mediates Macrophag...