Exploring Experimental Hematology: RUNX1 and the Endothelial Origin of Blood

In this issue of Simply Blood, Teresa Bowman is exploring Experimental Hematology by highlighting and deconstructing one of her favorite manuscripts from the ISEH society journal: "RUNX1 and the Endothelial Origin of Blood" by Gao et al.

The functionality of hematopoietic stem cells (HSCs) to replenish and maintain the entire hematopoietic system is the basis for bone marrow transplantation, one of the most well established stem cell-based therapies. Transplantation is curative for many hematologic disorders, but immune-matched donor cells remain limited for many patients. Understanding how HSCs form endogenously during development should provide key insights into expanding donor HSCs from existing sources or generating HSCs from pluripotent stem cells. HSCs first arise during embryonic development through an endothelial-to-hematopoietic transition. Extensive work over the past decade has revealed that not all endothelial cells possess the capacity to form blood cells, and t…

Leading a Research Group in Europe - Part I: France

Throughout the next few months ISEH member, Christophe Lancrin, will be highlighting his professional journey working in various European countries. This month we travel to France to explore Christophe's knowledge about the two main state-funded scientific organizations and the most typical way to enter the French system.

“When in Rome, do as the Roman’s do”, I think we have heard this phrase when we want to emphasize that each country may have their own way to do certain things. But have you wonder if “Roman’s” have a specific way to become and being a Principal Investigator? The short answer is yes, and not only Italian’s but I found differences among at least three different European countries that I have worked. Whether you are looking for a job opportunity in Europe or just to expand your knowledge on how is to do research among different countries, I am sure you will find this Blog series very useful.

Over my research career, I have worked in France, United Kingdom and Ital…

Lab Spotlight: Butler lab

Each month, Simply Blood spotlights a lab focused on the research of basic hematology, immunology, stem cell research, cell and gene therapy, and other related aspects. Get to know these different labs around the world! This month, we are featuring the Butler lab at the Center for Discovery and Innovation, Hackensack University Medical Center, in New Jersey.

About the PI: Jason Butler is an Associate Professor at the Center for Discovery and Innovation (CDI), Hackensack University Medical Center. He earned his Ph.D. at the University of Florida (2001-2005), under the supervision of Edward Scott. He then moved to New York as a postdoctoral fellow in the lab of Shahin Rafii, at Weill Cornell, where he primarily studied the role of bone marrow endothelial cells in hematopoiesis (2006-2010). In 2011 he started his own research group at Weill Cornell, to further investigate how to modulate hematopoietic vascular niches in the context of embryonic development, aging and blood malignanci…

Exploring Experimental Hematology: MISTRG

In this issue of Simply Blood, Leonid Olender is Exploring Experimental Hematology and highlighting and deconstructing one of his favorite manuscripts from the ISEH society journal: "MISTRG Mice Support Engraftment and Assessment of Nonhuman Primate Hematopoietic Stem and Progenitor Cells."

Development of novel Hematopoietic Stem and Progenitor Cell (HSPC)-mediated gene therapy strategies for various hematological disorders has become a popular and highly competitive niche of biomedical research over the past two decades. One of the main challenges in the field is development of animal models that would allow to check the efficiency of such new therapies, as well as to address safety issues before proceeding to clinical trials. In their recent paper in Experimental Hematology Dr. Radtke and Dr. Rongvaux show how the MISTRG mouse they developed might be a useful tool to overcome these obstacles.

What to expect in this paper?

Non-human primates (NHPs) are commonly used as larg…

ISEH March 2019 – Message from the President: Bertie Gottgens

Dear Friends and Colleagues,

Many of you will have seen that the call for abstracts is now open for our annual meeting at  The official countdown to the 48th annual ISEH meeting has therefore begun.  I am really excited by the program put together by our scientific Program Committee, chaired by Emmanuelle Passegué, with a superb line-up of speakers across the broad research interests of our membership (

Please consider submitting an abstract and/or encourage others to do so.  In addition to securing a place in one of the legendary poster sessions at ISEH, 33 of the submitted abstracts will be selected for oral presentation at the meeting. Having such a large proportion of talks selected from submitted abstracts is indeed a distinguishing feature of the ISEH meeting.  As those of you who attend our meeting regularly will know, the abstract-selected talks often report the most-exciting and cuttin…

Announcing the 2019 ISEH Award Winners - David Scadden and David Traver

On behalf of the Awards Committee, we are very excited to announce the recipients of the 2019 International Society for Experimental Hematology (ISEH) Honorific Awards, which will be presented to David Scadden and David Traver at the Annual Scientific Meeting in Brisbane, Queensland, Australia. In addition to their well-recognized status as world-wide leaders in the field of Hematology, both recipients are long-standing and active members of the ISEH community. We have been educated and inspired by their scientific insights as well as impressed by their unwavering mentorship and leadership efforts, and hope you will join us in offering them our sincere congratulations for their well-deserved receipt of our highest ISEH honors.

McCulloch and Till Award – David Traver
This award is intended to recognize early to mid-career scientists who have made a substantial impact in the field of Hematology

David Traver PhD, Professor of Cellular and Molecular Medicine, and of Cell and Developmental Bi…

Lab Spotlight: Steidl Lab

Each month, Simply Blood spotlights a lab focused on the research of basic hematology, immunology, stem cell research, cell and gene therapy, and other related aspects.  Get to know these different labs around the world! This month, we are featuring the Steidl Lab at Albert Einstein College of Medicine in Bronx, New York, USA.

How long have you had your lab?   
11 years

How many members make up your lab? Students/postdocs?  
14 total, 5 graduate students, 6 postdocs, 3 technicians

What is the major research theme of your lab?   
Molecular Regulation and Targeting of Pre-Cancerous and Cancer Stem Cells in Hematopoiesis and Leukemogenesis

What is the most exciting project in your lab right now?  
We have several highly exciting projects going on in the lab right now. One project I am particularly excited about is using single molecule analysis to study transcription state dynamics in normal and malignant stem cell differentiation. Through a novel methodology at the single cell and si…