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The second edition of the Simply Blood Preprint Watch includes 14 preprints, covering clonal dynamics, AML biology and tumor-immune dynamics! We are also happy to showcase a preprint directly contributed by the community, so if you want to see your preprint featured as well, complete a brief submission form . From the Simply Blood Community : A Pax3 lineage gives rise to transient haematopoietic progenitors https://www.biorxiv.org/content/10.1101/2024.06.26.600366v1  This study describes a new source of transient haematopoietic progenitors in the mouse embryo belonging to a Pax3 lineage. These progenitors appear to be transient EMP-like cells that do not originate in the yolk sac and do not persist in adulthood.  STEM AND PROGENITOR CELLS BIOLOGY Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy https://www.biorxiv.org/content/10.1101/2024.09.09.612140v1 Somatic mutations in TET2, a common driver of clonal hematopoiesis, enhance the res...

This week on Simply Blood we interviewed the 2024 Award Winner for Leadership in Diversity, Equity and Inclusion, Katherine King, MD, PhD . Dr. King shares tips and activities to build an inclusive lab environment, how to be a better mentor and role model of DEI, and highlights her lab's research! 2024 Leadership in Diversity, Equity and Inclusion Award Winner Katherine King, MD, PhD Professor, Pediatrics-Infectious Disease Baylor College of Medicine Houston, TX Learn more about Dr. King's contributions to DEI by reading her latest blog post published in Baylor College of Medicine, Easy ways to incorporate inclusion into a busy academic life . Interviewed by Alba Rodriguez-Meira of the ISEH New Investigators Committee. Please note that the statements made by Simply Blood Authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

  Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Vanuytsel Lab which is based out of the Center for Regenerative Medicine, Boston University. How long has your lab been open and who is in your lab currently? The lab opened in July 2023 and currently consists of a lab manager, a PhD student, a postdoc and three undergraduate researchers. What is the overarching research goal for your group? Our lab studies concepts at the intersection of hematopoietic development, stem cell biology and sickle cell disease. We are trying to gain an in-depth understanding of engraftment potential and how that is orchestrated during development so that we can harness those insights to improve stem cell engraftment in the context of gene therapy and stem cell transplantations. What we learn from stu...

  This month, we're excited to introduce a new series on Simply Blood, where we'll highlight preprints relevant to the ISEH community. We hope you find it engaging, and we welcome any feedback you'd like to share! If there's a specific preprint you enjoyed and would like to see featured, please send it to us using this form ! STEM AND PROGENITOR CELLS BIOLOGY Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2024.10.11.617794v1?rss=1  Human Fetal Liver-like Organoids (FLOs) recreate the hepato-hematopoietic interactions of fetal liver development, establishing a niche that supports hematopoietic progenitor differentiation without external factors. In this paper, Rezvani and colleagues show that FLOs can model the integration of hematopoietic and hepatic lineages, showcasing multipotent progenitors with myeloid lineage bias and the potential for fet...

  Experimental Hematology: Young Investigator articles of 2023 Experimental Hematology has reviewed articles published in 2023.   Among the articles highlighted are two Young Investigator articles that both explore important biological questions in normal and malignant hematopoiesis using murine models. Rydström et al investigate how the hematopoietic stem cells regenerate after transplantation. The process where quiescent hematopoietic stem cells start to proliferate to replenish the hematopoietic system, and how they gradually return to homeostasis and quiescence is studied. To capture the dynamics of the process, HSPCs were transplanted and 8 different timepoints surveyed. The repopulating cells were studied at the transcriptional and functional levels. Differential expression of cell cycle genes and metabolic changes were observed during the process. The authors also investigate the functional capacity of the regenerating HSCs and found that it increases with time. A...

  Samanta Mariani’s lab From left to right - Hollie Vaughan (PhD student) - Malgorzata Rumowksa (visiting student) - Samanta Mariani - Hena Modha (Master student) - Eva Doyle (PhD student) Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Mariani Lab which is based out of the Centre for Inflammation Research, The University of Edinburgh. How long have you had your lab and how many members make up your lab?  Three years now. Brief but very intense. Currently, we have two PhD students, one Master student and one visiting student. What is the major research theme of your lab? Our major interest is to understand how embryonic macrophages interact with hematopoietic stem and progenitor cells at steady-state and in mouse models of infant leukemia, where the leukemic cells first a...