simply blood

In this issue of Simply Blood, we are highlighting and deconstructing an invited perspective from the latest Experimental Hematology, "Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single-cell and lineage tracing technologies" by Loughran et al. This perspective summarizes the Summer 2019 ISEH New Investigator Committee Webinar, "Changing concepts in lineage commitment" and update the recent progress of understanding lineage commitment using lineage tracing combined with single-cell transcriptomics and proteomics. (Loughran et al., 2020)


My reason to read this paper:

The self-renewal and multilineage differentiation abilities are two essential characteristics of hematopoietic stem cells (HSCs). In the history of the hematopoietic field, to understand the cell fate determination and lineage potential from each HSC and progenitor population, people have taken various strategies including colony-forming assays, stromal co-culture, …

The ISEH Annual Meeting looked a bit different this year. We celebrated the 2020 Virtual Scientific Meeting with our exciting program including career and technology sessions, as well as talks and poster presentations from trainees, new investigators and leaders in the field.
On behalf of the ISEH Board of Directors, volunteers, and staff, we'd like to thank our 2020 sponsors and exhibitors, seen below. We hope to see you all in New York in 2021!
This program is supported by an independent medical education grant by Celgene Corporation.
THANK YOU TO OUR 2020 GOLD SPONSOR

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Funding for this conference was made possible (in part) by 1R13HL154589-01 from the National Heart, Lung and Blood Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention by trade names, c…

This week on Simply Blood we are wrapping up our 2020 Interview Spotlight Series. In Part IV we are featuring the 2020 ISEH Donald Metcalf Award Winner: Harvey Lodish, MD. Here, he answers questions about his life, work, mentorship, and more. Have additional questions for Dr. Lodish? Don't miss his opening Keynote session at this year’s Virtual Scientific Meeting!

In this issue of Simply Blood, we are highlighting and deconstructing one of the journal’s latest manuscripts by first author Darlene A. Monlish. In a recent study in the laboratory of Dr. Laura Schuettpelz (Washington University School of Medicine), Monlish et al described heterodimer-specific effects of TLR2 signaling on premalignant hematopoietic stem and progenitor cells (HSPCs) in a mouse model of myelodysplastic syndromes (MDS). (Monlish et al., 2020).
TLR2 expression is increased on the HSPCs of patients with MDS, however its role in MDS pathogenesis is not clear. Notably, TLR2 heterodimerizes with TLR1 or TLR6, and while high TLR2 is associated with lower-risk disease, high TLR6, but not TLR1, correlates with higher-risk disease. This raises the possibility of heterodimer-specific effects of TLR2 signaling in MDS. Indeed, the authors found that chronic stimulation of TLR2/6 (but not TLR1/2) signaling accelerated leukemic transformation in a NUP98-HOXD13 (NHD13) mouse model of M…

This week on Simply Blood we are continuing our 2020 Interview Spotlight Series. In Part III we are featuring the inaugural ISEH Janet Rowley Award Winner: Jennifer Trowbridge, Ph.D.. Dr. Trowbridge’s lab studies cell fate regulation within the hematopoietic system, with a current focus on the epigenetic regulation of hematopoietic stem cells and progenitor cell lineage commitment. Here, she answers questions about her work, trends in hematology, mentorship, and more. Have additional questions for Dr. Trowbridge? Don't miss her session at this year’s Virtual Scientific Meeting!
1. What was the biggest challenge that you had to face in your career so far? Recruiting a team of scientists that I fully believed in, and felt inspired by, took much longer than I anticipated after starting my lab. It was a significant challenge starting a laboratory in a fairly remote location and there were times when I honestly thought this dream would not happen. What it took for me to get through that …

Exploring Experimental Hematology: Engineering of targeted megabase-scale deletions in human induced pluripotent stem cells
In this issue of Simply Blood, we are highlighting and deconstructing one of the journal’s latest manuscripts by first author Andriana G. Kotini. This paper is an extension of the Papapetrou Lab’s ongoing work focused on modeling myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using human induced pluripotent stem cells (iPSCs). [https://www.exphem.org/article/S0301-472X(20)30193-4/]
Reason to read this paper: AML is one of the most common malignancies of adulthood, comprising about 1/3 of all new leukemia cases diagnosed in the United States each year. AML often develops from MDS, a preleukemic condition of HSC failure caused by recurrent somatic mutations and chromosomal aberrations in HSC clones that impair their effective differentiation. MDS occurs sporadically in older adults but can frequently affect younger people with inherited bone marrow fa…