Webinar Re-cap: The Role of Inflammatory Signals in Embryonic HSC Development and Adult HSC Function
Inflammation is a double-edged sword. Inflammatory signals are needed to fight infections, yet too much can contribute to hematologic diseases such as bone marrow failure and malignancy. In recent years since the discoveries from our group and the group of Peggy Goodell that the pro-inflammatory cytokines Interferonα (IFNα) and IFNγ lead to activation of quiescent hematopoietic stem cells (HSCs) in vivo , there has been a revival to uncover the role of these cytokines in the HSCs and the hematopoietic system as a whole. A recent webinar from ISEH entitled “ The Role of Inflammatory Signals in Embryonic HSC Development and Adult HSC Function ” presents work exploring the role of inflammation in disease and development from leaders in the field- Markus Manz (University Hospital in Zurich), Trista North (Harvard Medical School), and moderated by Katherine King (Baylor College of Medicine). In general, pro-inflammatory cytokines are produced by cells of the immune system in response to