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Showing posts from March, 2019

Exploring Experimental Hematology: MISTRG

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In this issue of Simply Blood, Leonid Olender is Exploring Experimental Hematology and highlighting and deconstructing one of his favorite manuscripts from the ISEH society journal: "MISTRG Mice Support Engraftment and Assessment of Nonhuman Primate Hematopoietic Stem and Progenitor Cells."



Development of novel Hematopoietic Stem and Progenitor Cell (HSPC)-mediated gene therapy strategies for various hematological disorders has become a popular and highly competitive niche of biomedical research over the past two decades. One of the main challenges in the field is development of animal models that would allow to check the efficiency of such new therapies, as well as to address safety issues before proceeding to clinical trials. In their recent paper in Experimental Hematology Dr. Radtke and Dr. Rongvaux show how the MISTRG mouse they developed might be a useful tool to overcome these obstacles.

What to expect in this paper?

Non-human primates (NHPs) are commonly used as larg…

ISEH March 2019 – Message from the President: Bertie Gottgens

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Dear Friends and Colleagues,

Many of you will have seen that the call for abstracts is now open for our annual meeting at https://www.iseh.org/page/2019AbstractsandSpeakers.  The official countdown to the 48th annual ISEH meeting has therefore begun.  I am really excited by the program put together by our scientific Program Committee, chaired by Emmanuelle Passegué, with a superb line-up of speakers across the broad research interests of our membership (https://www.iseh.org/page/2019Program).

Please consider submitting an abstract and/or encourage others to do so.  In addition to securing a place in one of the legendary poster sessions at ISEH, 33 of the submitted abstracts will be selected for oral presentation at the meeting. Having such a large proportion of talks selected from submitted abstracts is indeed a distinguishing feature of the ISEH meeting.  As those of you who attend our meeting regularly will know, the abstract-selected talks often report the most-exciting and cuttin…

Announcing the 2019 ISEH Award Winners - David Scadden and David Traver

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On behalf of the Awards Committee, we are very excited to announce the recipients of the 2019 International Society for Experimental Hematology (ISEH) Honorific Awards, which will be presented to David Scadden and David Traver at the Annual Scientific Meeting in Brisbane, Queensland, Australia. In addition to their well-recognized status as world-wide leaders in the field of Hematology, both recipients are long-standing and active members of the ISEH community. We have been educated and inspired by their scientific insights as well as impressed by their unwavering mentorship and leadership efforts, and hope you will join us in offering them our sincere congratulations for their well-deserved receipt of our highest ISEH honors.

McCulloch and Till Award – David Traver
This award is intended to recognize early to mid-career scientists who have made a substantial impact in the field of Hematology

David Traver PhD, Professor of Cellular and Molecular Medicine, and of Cell and Developmental Bi…

Lab Spotlight: Steidl Lab

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Each month, Simply Blood spotlights a lab focused on the research of basic hematology, immunology, stem cell research, cell and gene therapy, and other related aspects.  Get to know these different labs around the world! This month, we are featuring the Steidl Lab at Albert Einstein College of Medicine in Bronx, New York, USA.



How long have you had your lab?   
11 years

How many members make up your lab? Students/postdocs?  
14 total, 5 graduate students, 6 postdocs, 3 technicians

What is the major research theme of your lab?   
Molecular Regulation and Targeting of Pre-Cancerous and Cancer Stem Cells in Hematopoiesis and Leukemogenesis

What is the most exciting project in your lab right now?  
We have several highly exciting projects going on in the lab right now. One project I am particularly excited about is using single molecule analysis to study transcription state dynamics in normal and malignant stem cell differentiation. Through a novel methodology at the single cell and si…