Showing posts from May, 2024

Exploring Experimental Hematology: March 2024 (Volume 131)

G-CSF−induced hematopoietic stem cell mobilization from the embryonic hematopoietic niche does not require neutrophils and macrophages   (Ji Wook Kim, Evan A. Fedorova, and Leonard I. Zon) In this issue of Simply Blood, we are highlighting one of the journal’s latest manuscripts by first author Ji Wook Kim. This study was conducted in Dr. Leonard Zon’s laboratory (Department of Stem Cell and Regenerative Biology, Harvard Medical School) and has demonstrated that the Granulocyte colony-stimulating factor (G-CSF) induced hematopoietic stem and progenitor cell (HSPC) mobilization from the embryonic hematopoietic niche in not neutrophil and macrophage depended. The discrepancies in literature suggesting G-CSF either acts directly to mobilize HSPCs or requires myeloid cells has created ambiguity regarding the mechanism of action of G-CSF. Kim et al, developed a stable transgenic line with a heat-inducible csf3b , a zebrafish ortholog of human CSF3 , which translates into G-CSF and confirme

Lab Spotlight: Nachmani Lab

Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Nachmani Lab which is based out of The Hebrew University of Jerusalem in Israel ( ). How long have you had your lab? 3.5 years, including a pandemic How many members make up your lab? Students/postdocs? The lab roster currently consists of 4 experimental master students, 1 computational master students, 5 undergrads and 1 postdoc. What is the major research theme of your lab? Molecular Hematopoiesis. We study the role of the ribosome itself, as a regulator of translation in hematopoietic stem cells. More specifically we focus of rRNA modifications, as regulators of cell-type-specific translation, and their importance for hematopoietic stem cells function and differentiation. We have several projects involv