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Exploring Experimental Hematology: March 2024 (Volume 131)

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G-CSF−induced hematopoietic stem cell mobilization from the embryonic hematopoietic niche does not require neutrophils and macrophages   (Ji Wook Kim, Evan A. Fedorova, and Leonard I. Zon) In this issue of Simply Blood, we are highlighting one of the journal’s latest manuscripts by first author Ji Wook Kim. This study was conducted in Dr. Leonard Zon’s laboratory (Department of Stem Cell and Regenerative Biology, Harvard Medical School) and has demonstrated that the Granulocyte colony-stimulating factor (G-CSF) induced hematopoietic stem and progenitor cell (HSPC) mobilization from the embryonic hematopoietic niche in not neutrophil and macrophage depended. The discrepancies in literature suggesting G-CSF either acts directly to mobilize HSPCs or requires myeloid cells has created ambiguity regarding the mechanism of action of G-CSF. Kim et al, developed a stable transgenic line with a heat-inducible csf3b , a zebrafish ortholog of human CSF3 , which translates into G-CSF and confirme

Lab Spotlight: Nachmani Lab

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Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Nachmani Lab which is based out of The Hebrew University of Jerusalem in Israel ( https://www.nachmanilab.com/ ). How long have you had your lab? 3.5 years, including a pandemic How many members make up your lab? Students/postdocs? The lab roster currently consists of 4 experimental master students, 1 computational master students, 5 undergrads and 1 postdoc. What is the major research theme of your lab? Molecular Hematopoiesis. We study the role of the ribosome itself, as a regulator of translation in hematopoietic stem cells. More specifically we focus of rRNA modifications, as regulators of cell-type-specific translation, and their importance for hematopoietic stem cells function and differentiation. We have several projects involv

ISEH 2024 Society Award Winners

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On behalf of the Awards Committee, ISEH would like to congratulate the recipients of the 2024 ISEH Society Awards which will be presented at the ISEH 53rd Annual Scientific Meeting . Donald Metcalf Award Winner - Emmanuelle Passegué The 2024 Donald Metcalf Award goes to Dr. Emmanuelle Passegué for her outstanding work in the fields of normal and malignant hematopoietic stem cell biology. Dr. Passegué, Alumni Professor of Genetics & Development and Director of the Columbia Stem Cell Initiative (CSCI) at Columbia University Irving Medical Center in New York city, receives the highest honor bestowed by the Society for her distinguished work as an outstanding scientist, leader, and role model.  Dr. Passegué grew up in France, and after PhD studies at the Collège de France in Paris she went on to postdoctoral research, first with Dr. Erwin Wagner at the Institute of Molecular Pathology in Vienna and with Dr. Irv. Weissman at Stanford University. In 2005, she started her own independent

Remembering Professor Connie Eaves: an exceptional researcher, mentor and friend.

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On March 7, 2024, the Experimental Hematology community lost a legend. Editor of our journal (2017- June 2023), and a member of the International Society for Experimental Hematology (ISEH) for over 50 years, Professor Connie Eaves was thoroughly devoted to ISEH and its community of researchers. She contributed significantly to the ISEH leadership, notably as President (2002-2003) and was the highly deserving recipient of both the Donald Metcalf Award (2008) and the Outstanding Mentor award (2023). Upon accepting her Mentorship award, Connie declared how proud she was of ISEH - that it was a wonderful scientific meeting and community - and her passion for the society shone through. She worked tirelessly, both for scientific advances and to create opportunities for young scientists. She touched the lives of countless researchers along the way and she will be dearly missed. Connie and Allen at dinner at the close of the New York ISEH 2023 Meeting at which Connie received the ISEH Outs

ISEH 2024 Career Fair

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It is time to gear up for the 3rd edition of the Virtual Career Fair ! We've pulled out all the stops to unveil an electrifying platform that transforms networking with some of the best PIs in experimental hematology into a thrilling 'speed meet.' Get ready to fast-track your career in a dynamic and interactive virtual environment! The ISEH New Investigator Committee is thrilled to present the ISEH 2024 Virtual Postdoc Career Fair scheduled for Tuesday, April 16, 2024, from 15:00-16:00 CDT ( Click to see in your date and time ). This event is open and free for all PhD students and postdocs around the world. You do not need an ISEH membership to participate. It is FREE! Secure your spot by clicking here to register. What to anticipate? Upon registration, participants will receive a link to access an online networking platform. In this virtual setting, each hiring principal investigator will engage in several ‘speed networking’ talks with potential candidates to fulfill th

Lab Spotlight: Tamplin Lab

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Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Tamplin Lab which is based out of the University of Wisconsin-Madison in the United States ( https://tamplin.crb.wisc.edu/staff/tamplin-owen/ ). How long has your lab been open and who is in your lab currently? The lab first opened in January 2016 at the University of Illinois at Chicago, and we moved to the University of Wisconsin Madison during the pandemic in 2020. The lab currently has three graduate students, five undergraduates and one research technician. What is the overarching research goal for your group? The main research theme is the hematopoietic stem cell microenvironment. We use zebrafish and mouse and models. We are interested in utilizing new technologies through collaboration to apply to our interest in the microen

Getting Involved in Science Policy (as a Scientist)

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What is science policy? Science policy is a broad term encompassing a range of different career paths relevant to governmental allocation of resources towards scientific research. This can include job roles such as science communicator, science policy analyst, and scientific advisor for government agencies. Because of the large amount of funding needed for scientific research, legislation concerning scientific policy in most countries is often approved at a national or international level, and only a few countries have a provincial or state-level scientific policy apparatus. How do different science policy roles fit together? Science policy often starts with an advocacy group (such as scientists in ISEH) having a special interest in passing a piece of legislation (such as governmental funding to study a disease, or modifying regulations surrounding a research topic). In the US, an advocacy group starts by meeting with the staff of an elected representative who sits on the relevant comm