simply blood

This week on Simply Blood we are continuing our Interview Spotlight Series. In Part III we are featuring the ISEH 2024 New Investigators Committee Invited Speaker: Leïla Perié, PhD . Dr.  Perié  shared her journey of changing her career path, the challenges she encountered along the way, her valuable advice for running a successful lab and more! Interested in hearing more about  Dr.  Perié's work?  Don’t miss her session at the ISEH 53rd Annual Scientific Meeting this September !     Leïla Perié, PhD Team Leader, Quantitative Immuno-hematology Institut Curie Interviewed by Myriam Haltalli of the ISEH New Investigators Committee. Please note that the statements made by Simply Blood Authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

This week on Simply Blood we are continuing our Interview Spotlight Series. In Part II we are featuring the ISEH 2024 Donald Metcalf Awardee:  Emmanuelle Passegué, PhD. Dr.  Passegué answers questions about her scientific passions, career path, advice for trainees and more! Interested in hearing more about  Dr.  Passegué's work?  Don’t miss her session at the ISEH 53rd Annual Scientific Meeting this September ! Emmanuelle Passegué, PhD Director, Columbia Stem Cell Initiative Columbia University Irving Medical Center 2024 Donald Metcalf Award Recipient Interviewed by Anne Stolz of the ISEH New Investigators Committee. Please note that the statements made by Simply Blood Authors are their own views and not necessarily the views of ISEH. ISEH disclaims any or all liability arising from any author's statements or materials.

This week on Simply Blood we are kicking off our Interview Spotlight Series. In Part I we are featuring the ISEH 2024 McCulloch & Till Awardee: Ravindra 'Ravi' Majeti MD, PhD. Dr. Majeti reflects on his scientific achievements, career inspirations, entrepreneurial ventures, and looks towards the future of hematologic research. Interested in hearing more about Dr. Majeti's fascinating work?  Don’t miss his session at the ISEH 53rd Annual Scientific Meeting this September !                                                                                                                                                                                            Ravindra 'Ravi' Majeti MD, PhD RZ Cao Professor of Medicine Chief of the Division of Hematology Member of the Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine 2024 McCulloch & Till Award Recipient Interviewed by Ian Hsu of the  ISEH New Investigators Committe

  Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Elf Lab which is based out of the Huntsman Cancer Institute, University of Utah ( https://www.elflab.org/ ). What does your lab study? The primary focus of my lab is to understand the molecular mechanisms that govern myeloid blood cancers, with particular emphasis on MPNs. The long-term vision of my research program is to elucidate molecular dependencies specific to MPN stem cells (MPN-SCs) that can be targeted for therapeutic intervention with the ultimate goal of eradicating MPN-SCs, sparing normal HSCs, and curing the disease. When I first started my lab, we were particularly interested in how CALR mutations hijack ER stress response pathways to promote survival. Through these studies, we found that though type 1 and type 2 CALR mu

  Assessment of a novel NRAS in-frame tandem duplication causing a myelodysplastic/myeloproliferative neoplasm Cora C.A. Beckmann, Senthilkumar Ramamoorthy, Eirini Trompouki, Wolfgang Driever, Stephan Schwarz-Furlan, Brigitte Strahm, Ayami Yoshimi, Charlotte M. Niemeyer, Miriam Erlacher, Friedrich G. Kapp Myeloproliferative neoplasms (MPNs) and myelodysplastic syndrome (MDS) are rare hematologic disorders in children that can only be cured by hematopoietic stem cell transplantation (HSCT).  The genetics of pediatric MPN and MDS are only partially understood and are extrapolated from epidemiologic studies in older adults.  RAS pathway mutations often occur in pediatric MPN and MDS, and children with predisposition for these conditions often bear germline mutations in components of the RAS signaling pathway.  Led by Dr. Kapp at the Faculty of Medicine, University of Freiburg, the authors describe a 2-year-old patient with pancytopenia, massive splenomegaly with myeloid and erythroid prec

Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Yamazaki Lab which is based out of The Institute of Medical Science, The University of Tokyo in Japan ( https://www.cbms.k.u-tokyo.ac.jp/en/labs/yamazaki/ ). You have quite a unique career path, aren’t you? So when and how did you start considering becoming a PI? I did not think I would be able to become a PI in the past. (*Prof. When he started working in this field, Yamazaki was a technical staff, not even a bachelor's student.) At that time, simply performing experiments was fun, so I did not prioritize obtaining academic degrees. Later, however, I started feeling more fun writing a paper by myself, with which I could connect myself and discuss science with other national and international researchers worldwide. My desire to spre

G-CSF−induced hematopoietic stem cell mobilization from the embryonic hematopoietic niche does not require neutrophils and macrophages   (Ji Wook Kim, Evan A. Fedorova, and Leonard I. Zon) In this issue of Simply Blood, we are highlighting one of the journal’s latest manuscripts by first author Ji Wook Kim. This study was conducted in Dr. Leonard Zon’s laboratory (Department of Stem Cell and Regenerative Biology, Harvard Medical School) and has demonstrated that the Granulocyte colony-stimulating factor (G-CSF) induced hematopoietic stem and progenitor cell (HSPC) mobilization from the embryonic hematopoietic niche in not neutrophil and macrophage depended. The discrepancies in literature suggesting G-CSF either acts directly to mobilize HSPCs or requires myeloid cells has created ambiguity regarding the mechanism of action of G-CSF. Kim et al, developed a stable transgenic line with a heat-inducible csf3b , a zebrafish ortholog of human CSF3 , which translates into G-CSF and confirme

Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Nachmani Lab which is based out of The Hebrew University of Jerusalem in Israel ( https://www.nachmanilab.com/ ). How long have you had your lab? 3.5 years, including a pandemic How many members make up your lab? Students/postdocs? The lab roster currently consists of 4 experimental master students, 1 computational master students, 5 undergrads and 1 postdoc. What is the major research theme of your lab? Molecular Hematopoiesis. We study the role of the ribosome itself, as a regulator of translation in hematopoietic stem cells. More specifically we focus of rRNA modifications, as regulators of cell-type-specific translation, and their importance for hematopoietic stem cells function and differentiation. We have several projects involv

On behalf of the Awards Committee, ISEH would like to congratulate the recipients of the 2024 ISEH Society Awards which will be presented at the ISEH 53rd Annual Scientific Meeting . Donald Metcalf Award Winner - Emmanuelle Passegué The 2024 Donald Metcalf Award goes to Dr. Emmanuelle Passegué for her outstanding work in the fields of normal and malignant hematopoietic stem cell biology. Dr. Passegué, Alumni Professor of Genetics & Development and Director of the Columbia Stem Cell Initiative (CSCI) at Columbia University Irving Medical Center in New York city, receives the highest honor bestowed by the Society for her distinguished work as an outstanding scientist, leader, and role model.  Dr. Passegué grew up in France, and after PhD studies at the Collège de France in Paris she went on to postdoctoral research, first with Dr. Erwin Wagner at the Institute of Molecular Pathology in Vienna and with Dr. Irv. Weissman at Stanford University. In 2005, she started her own independent

On March 7, 2024, the Experimental Hematology community lost a legend. Editor of our journal (2017- June 2023), and a member of the International Society for Experimental Hematology (ISEH) for over 50 years, Professor Connie Eaves was thoroughly devoted to ISEH and its community of researchers. She contributed significantly to the ISEH leadership, notably as President (2002-2003) and was the highly deserving recipient of both the Donald Metcalf Award (2008) and the Outstanding Mentor award (2023). Upon accepting her Mentorship award, Connie declared how proud she was of ISEH - that it was a wonderful scientific meeting and community - and her passion for the society shone through. She worked tirelessly, both for scientific advances and to create opportunities for young scientists. She touched the lives of countless researchers along the way and she will be dearly missed. Connie and Allen at dinner at the close of the New York ISEH 2023 Meeting at which Connie received the ISEH Outs

It is time to gear up for the 3rd edition of the Virtual Career Fair ! We've pulled out all the stops to unveil an electrifying platform that transforms networking with some of the best PIs in experimental hematology into a thrilling 'speed meet.' Get ready to fast-track your career in a dynamic and interactive virtual environment! The ISEH New Investigator Committee is thrilled to present the ISEH 2024 Virtual Postdoc Career Fair scheduled for Tuesday, April 16, 2024, from 15:00-16:00 CDT ( Click to see in your date and time ). This event is open and free for all PhD students and postdocs around the world. You do not need an ISEH membership to participate. It is FREE! Secure your spot by clicking here to register. What to anticipate? Upon registration, participants will receive a link to access an online networking platform. In this virtual setting, each hiring principal investigator will engage in several ‘speed networking’ talks with potential candidates to fulfill th

Each month, Simply Blood spotlights a lab contributing to the fields of hematology, immunology, stem cell research, cell and gene therapies, and more. Get to know groups doing cutting edge research from around the world! This month, we are featuring the Tamplin Lab which is based out of the University of Wisconsin-Madison in the United States ( https://tamplin.crb.wisc.edu/staff/tamplin-owen/ ). How long has your lab been open and who is in your lab currently? The lab first opened in January 2016 at the University of Illinois at Chicago, and we moved to the University of Wisconsin Madison during the pandemic in 2020. The lab currently has three graduate students, five undergraduates and one research technician. What is the overarching research goal for your group? The main research theme is the hematopoietic stem cell microenvironment. We use zebrafish and mouse and models. We are interested in utilizing new technologies through collaboration to apply to our interest in the microen

What is science policy? Science policy is a broad term encompassing a range of different career paths relevant to governmental allocation of resources towards scientific research. This can include job roles such as science communicator, science policy analyst, and scientific advisor for government agencies. Because of the large amount of funding needed for scientific research, legislation concerning scientific policy in most countries is often approved at a national or international level, and only a few countries have a provincial or state-level scientific policy apparatus. How do different science policy roles fit together? Science policy often starts with an advocacy group (such as scientists in ISEH) having a special interest in passing a piece of legislation (such as governmental funding to study a disease, or modifying regulations surrounding a research topic). In the US, an advocacy group starts by meeting with the staff of an elected representative who sits on the relevant comm