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Exploring Experimental Hematology: August 2020 (Volume 88)

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In this issue of Simply Blood, we are highlighting and deconstructing an invited perspective from the latest Experimental Hematology, "Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single-cell and lineage tracing technologies" by Loughran et al. This perspective summarizes the Summer 2019 ISEH New Investigator Committee Webinar, "Changing concepts in lineage commitment" and update the recent progress of understanding lineage commitment using lineage tracing combined with single-cell transcriptomics and proteomics. (Loughran et al., 2020)


My reason to read this paper:

The self-renewal and multilineage differentiation abilities are two essential characteristics of hematopoietic stem cells (HSCs). In the history of the hematopoietic field, to understand the cell fate determination and lineage potential from each HSC and progenitor population, people have taken various strategies including colony-forming assays, stromal co-culture, …