We have all read many articles about the possible career choices of a scientist. The usual dilemma is between industry and academia. We have talked about this in previous blogs but the more information we get the easier it is to make a wise choice. Of course we all have opinions about the pros and cons of such a choice but what I always find best is to ask people who have experienced both. That is why I turned to an old colleague and friend, Elizabeth Paik, and asked her some questions regarding her experiences in both academia and industry.
Can you describe to us
your scientific career?
I started my career at Harvard Medical
School, as a graduate student in Dr. Len Zon's laboratory. My thesis work focused
on understanding a role of CDX transcription factors during embryonic
hematopoiesis. Through ChIP-seq, knockdown and overexpression studies in
zebrafish, I showed CDX transcription factors control expression of
hematopoietic transcription factors - SCL and LMO2.
Towards the end of my PhD, ES and iPS field
was blooming, and I got fascinated by how stem cells can be used to study human
diseases. At the same time, I wanted to pursue translational research, having
focused on basic biology during my PhD. I joined Dr. Lee Rubin's group at
Harvard Stem and Regenerative Biology department. While in his lab, I used
human iPS-derived dopaminergic neurons to study Parkinson’s disease. I also
co-developed a purification method for midbrain dopaminergic progenitors to
establish cell-based therapies for Parkinson’s disease.
After finishing my third year as a postdoc, I
started my first job in industry as a scientist at CRISPR Therapeutics. I have
been at CRISPR for nine months now, and it has been a very exciting and
Why did you choose to
continue your career in industry?
I joined industry to pursue my interest in
translational research. When I was a graduate student, colleagues in the Zon lab
had discovered prostaglandin E2’s role in enhancing HSC self-renewal. Following
the initial discovery, my adviser founded a biotech company focusing on
translating this discovery into therapy. That was the first time when I saw how
findings from an academic laboratory can be translated into therapies, and how
industrial research can enable this transition. I thought being part of this later
process would be very fulfilling.
I also liked the aspect of teamwork in
industry. During my postdoc, I was working on a pharmaceutical company-funded
project. The project was a highly collaborative one, where myself and two other
postdocs worked towards establishing a stem cell therapy for Parkinson's
disease. It was really exciting to work closely with them, and knowing that
teamwork is a key in industry, I thought it would be a great fit for me.
Do you use the knowledge
that you received during your academic career for your industry career?
Being a research scientist, my daily job
includes bench work, and designing experiments. I use skill sets that I acquired
during my academic career every day. Back in graduate school, I had to custom-build
many molecular biology tools because zebrafish had fewer ready-to-go reagents
compared to other mammalian model organisms. Now that I am in a brand-new CRISPR
field, I cannot rely on ready-made tools and even if there were tools out
there, I have to run stringent quality checks on them. Therefore, my molecular
biology skill sets earned during PhD years are extremely handy.
Do you think it is easy to
transition from academia to industry?
I think getting the first job in industry can
be quite challenging. A lot of it depends on whether you are a good fit to the
job requirements and the company culture. Because the job search can take a
long time, it is important to stay positive through the process.
Do you feel you advance
your scientific knowledge in industry?
Yes. Being in a small company, I need to be
flexible and open to expand my knowledge of experimental tools and be creative
regarding new ideas. For example, I learned a lot about the genome editing field
since joining CRISPR Tx.
What is the difference
between research in academia and industry?
In industry, projects are goal-oriented, and
have deadlines. You are expected to plan and execute in a timely manner so that
you can achieve the milestones. You should be able to prioritize and
efficiently use your resources to meet these expectations.
What would you advise
someone who is lingering between an academic career and a career in industry?
I would actively reach out to people who
already have a job in an industry and find out what it is like to work there. When
I reached out to people, many candidly shared their experience, and I found it very
Hopefully Elizabeth’s experience will be handy to many people
looking for alternative careers out there. The key message is that transitioning
to another job never wastes your prior knowledge. However, it takes time to
find the right fit so you have to be patient, optimistic and take advice from
the right people
Disclaimer: The views expressed here are solely those of the
author and do not represent the views of the CRISPR Tx.
Elizabeth Paik, PhD
Scientist at CRISPR Tx
Cambridge, MA USA
Eirini Trompouki, PhD
ISEH Publications Committee Member
Max Planck Institute of Immunobiology and Epigenetics